All Disease Begins In The (Leaky) Gut: A Bold Claim, But Largely True

Secure Ordering | Free Shipping | 20% Off Retail Prices

Along with providing information on whether certain supplements for leaky gut might be right for you, this article also links to Fullscript where you can buy leaky gut supplements online through the secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Leaky gut is the common term for gastrointestinal hyperpermeability, a condition affecting many but understood by few. If looking to understand some of the basics of “leaky gut” and searching for supplements that can help, this article will provide the insight you need. We’ll discuss the causes, symptoms, and treatments, with a special focus on dietary supplements that can help. So, let’s broaden your knowledge on leaky gut and explore how the right supplements can make a significant difference in managing this condition.

“All Disease Begins In The Gut”

The ancient Greek physician Hippocrates once proclaimed, “All disease begins in the gut.” That thinking lost favor for much of the 20th century with modern medicine conceptualizing medical disorders as arising in different (and separate) systems of the body. More recently, the discovery of deeper root causes has emerged placing the gut at the center once again.

One particular aspect gaining attention is the concept of “leaky gut,” a condition where the intestinal lining becomes more permeable. This allows undigested proteins and bacterial cell walls (aka LPS or endotoxin) to enter the bloodstream. Recent breakthroughs, such as the discovery of zonulin, have deepened our understanding of leaky gut and its potential to cause wide-ranging health issues.

Leaky Gut Unmasked: Problems Linked to Immune Activation

Leaky gut opens the door for a precarious situation within our bodies. By permitting the passage of harmful substances such as toxins, bacteria, and undigested food particles from the digestive tract into the bloodstream, leaky gut triggers a cascade of events that can provoke immune activation and set the stage for a huge range of medical problems.

This disruptive process exposes our immune system to an onslaught of invaders, eliciting an inflammatory response that can reverberate throughout our bodies. The consequences of this immune activation extend far and wide, impacting various systems and contributing to a plethora of health complications. Understanding the profound impact of this permeability predicament is vital in comprehending the far-reaching consequences it can bestow upon our well-being.

From autoimmune diseases to allergies, gastrointestinal disorders, chronic fatigue, mental health conditions, skin ailments, metabolic disorders, neurological dysfunctions, and chronic systemic inflammation, the implications of a leaky gut reverberate across the entire spectrum of human health. Here is an extensive list of medical problems associated with leaky gut and immune activation:

• Autoimmune diseases: Leaky gut is believed to play a role in the development or exacerbation of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, lupus, and celiac disease.
• Allergies and food sensitivities: Increased intestinal permeability can contribute to the development of food allergies and sensitivities, as undigested food particles enter the bloodstream and trigger an immune response.
• Inflammatory bowel diseases (IBD): Leaky gut may contribute to the development or progression of conditions like Crohn’s disease and ulcerative colitis, which are characterized by chronic inflammation in the digestive tract.
• Irritable bowel syndrome (IBS): Some individuals with leaky gut may experience symptoms associated with IBS, such as abdominal pain, bloating, and changes in bowel habits.
• Chronic fatigue syndrome (CFS) and fibromyalgia: Leaky gut has been implicated in CFS and fibromyalgia, possibly due to increased inflammation and immune dysregulation.
• Mental health disorders: Emerging research suggests a potential link between leaky gut, immune activation, and mental health conditions such as depression, anxiety, and schizophrenia.
• Skin conditions: Leaky gut has been associated with skin conditions like acne, eczema, and psoriasis, potentially due to systemic inflammation and immune system dysfunction.
• Metabolic disorders: Some evidence suggests that leaky gut may contribute to metabolic disorders, including insulin resistance, obesity, and type 2 diabetes. [PMC9862683]
• Neurological disorders: Immune activation resulting from leaky gut has been implicated in the development or progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases.
• Chronic systemic inflammation: Leaky gut can contribute to chronic low-grade inflammation throughout the body, which is associated with an increased risk of various health problems, including cardiovascular disease and certain cancers.

What Food And Lifestyle Factors Affect Leaky Gut?

Several food and lifestyle factors can affect leaky gut:

• Food Choices:
  • Sugar Intake: Diets high in refined sugars and carbohydrates can promote the growth of harmful gut bacteria and yeast, potentially leading to inflammation and leaky gut.
  • Processed Foods: Processed foods often contain additives, preservatives, and artificial ingredients that can irritate the gut lining and disrupt the microbiome.
  • Lack of Fiber: A diet low in fiber can deprive the gut microbiome of essential nutrients and promote the growth of harmful bacteria.
  • Gluten: Gluten, found in wheat, barley, and rye, may contribute to leaky gut in some individuals, especially those with gluten sensitivity or celiac disease.
  • Dairy: Some people may be sensitive to dairy products, and consuming them can lead to digestive issues and inflammation in the gut.
  • Alcohol: Excessive alcohol consumption can damage the gut lining and disrupt the gut microbiome, potentially contributing to leaky gut.
  • Excessive Alcohol Consumption: Heavy drinking can disrupt the gut microbiome and damage the gut lining.
  • Overeating: Consuming large quantities of food in one sitting can overwhelm the digestive system and lead to digestive discomfort and potential gut irritation.
  • Inadequate Hydration: Dehydration can affect the mucus lining of the gut and reduce its protective function.
  • Inadequate Nutrient Intake: A diet lacking in essential nutrients can compromise the gut’s ability to repair and maintain its lining.
  • Food Sensitivities: Individual sensitivities to certain foods, such as gluten or dairy, can contribute to gut inflammation and permeability.
• Stress & Sleep:
  • Chronic Stress: Prolonged stress can weaken the gut lining and compromise the immune system, making it more susceptible to inflammation and damage.
  • Inadequate Sleep: Poor sleep patterns can affect gut health and the microbiome, as sleep is essential for the repair and regeneration of the gastrointestinal tract.
• Medications:
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Frequent use of NSAIDs like ibuprofen can irritate the gut lining and contribute to leaky gut.
  • Antibiotics: Antibiotics can disrupt the balance of gut bacteria, potentially leading to an overgrowth of harmful microbes.
• Infections:
  • Gut Infections: Bacterial, viral, or parasitic infections in the gastrointestinal tract can damage the gut lining and trigger inflammation.
• Environmental Toxins: Exposure to environmental toxins, such as pesticides and pollutants, can negatively impact gut health and contribute to leaky gut.
• Lack of Exercise: A sedentary lifestyle can reduce gut motility and slow down digestion, potentially leading to imbalances in the gut microbiome.
• Smoking: Smoking has been associated with gut dysbiosis and increased gut permeability.

It’s important to note that the impact of these factors on leaky gut can vary from person to person.

What Supplements Are Recommended For Leaky Gut?

• L-Glutamine: L-Glutamine is an amino acid known for its role in supporting gut health. It serves as a primary energy source for the cells lining the intestinal tract. During periods of gut stress or injury, such as in leaky gut syndrome, the demand for L-Glutamine increases. Supplementation with L-Glutamine can help replenish these cells and promote the repair of the gut lining. It also aids in maintaining the integrity of the intestinal barrier, potentially reducing the permeability that characterizes leaky gut. [PMC4369670]
• Aloe Vera: Aloe Vera is a plant known for its soothing properties, both for the skin and the digestive tract. In the context of leaky gut, Aloe Vera can help reduce inflammation and irritation in the gut lining. It contains compounds that have anti-inflammatory and antioxidant effects, which may contribute to its ability to alleviate discomfort and promote healing in the digestive system. [PMC8235210]
• Marshmallow Root: Marshmallow root contains mucilage, a gel-like substance that can provide a protective coating to the mucous membranes in the digestive tract. This mucilage can help soothe and calm the inflamed and irritated gut lining, offering relief from symptoms associated with leaky gut. By forming a protective barrier, it may also aid in preventing further damage to the gut lining. [PMC7090173]
• Deglycyrrhizinated Licorice (DGL): Licorice root, specifically in its deglycyrrhizinated form (DGL), is well-regarded for its potential to soothe and protect the gastrointestinal tract. DGL can help reduce inflammation and promote mucous production, which can aid in protecting the gut lining. It’s often used to address symptoms such as heartburn, indigestion, and irritation associated with conditions like leaky gut. [PMC8822647]
• Slippery Elm Bark: Slippery Elm bark contains mucilage, similar to Marshmallow Root, which can coat and soothe the digestive tract. It forms a protective layer along the gut lining, potentially reducing irritation and inflammation. This soothing effect can be particularly beneficial for individuals with leaky gut, as it may help alleviate discomfort and promote healing.
• Probiotics: Probiotics are beneficial bacteria that play a crucial role in maintaining a healthy balance of microorganisms in the gut. They help support the gut’s natural microbiome, which is essential for proper digestion, nutrient absorption, and immune function. Probiotics can also help regulate bowel movements and may reduce symptoms of digestive disorders like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). [PMID: 36007493][PMC10056128]
• Multivitamin: (will contain the following)
  • Zinc: Zinc is a mineral that supports gut health in multiple ways. It plays a role in gut lining repair, helping to maintain the integrity of the intestinal barrier. Additionally, zinc is essential for overall immune function, which is closely linked to gut health. Adequate zinc levels are necessary for a well-functioning immune system, and it can help in preventing and managing gut-related issues. [PMC9313088]
  • Vitamin D: Vitamin D is crucial for immune function, and it may also play a role in gut health. Many individuals with gut issues have been found to have low levels of vitamin D. Adequate vitamin D levels are essential for a well-regulated immune system, and supplementation may be necessary in some cases to address deficiencies and support immune health in the context of gut-related conditions. [PMC8396270]
  • B-vitamins: B-vitamins, including B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin), are essential for overall health, including gut function. These vitamins play various roles in the body, including aiding in energy metabolism, supporting the nervous system, and participating in the synthesis of DNA and RNA. In the context of gut health, B-vitamins are necessary for the proper functioning of the gastrointestinal system, as they contribute to the metabolism of carbohydrates, fats, and proteins. A deficiency in B-vitamins can lead to digestive issues and impact the health of the gut lining.
• Omega-3 Fatty Acids: Omega-3 fatty acids are essential fats found in fish oil, and they are well-known for their anti-inflammatory properties. In the context of gut health, omega-3 fatty acids can help reduce inflammation in the gastrointestinal tract. Chronic inflammation in the gut can lead to various digestive disorders, and omega-3s may help alleviate symptoms and support overall gut health. [PMC10468946]
• Berberine: Research suggests that berberine may help restore a healthy balance of gut bacteria, leading to improved gut barrier function and reduced permeability. [PMC7933196]
• Anti-Inflammatory Supplements:
  • Quercetin: Quercetin is a flavonoid with powerful antioxidant and anti-inflammatory properties. While it’s well-known for its role in reducing inflammation throughout the body, it can also have a positive impact on the digestive system. Quercetin may help soothe inflammation in the gut lining, making it potentially beneficial for individuals with conditions like irritable bowel syndrome (IBS) or leaky gut. Its antioxidant properties also contribute to overall digestive health. [PMC8621968]
  • Curcumin (Turmeric Extract): Curcumin is a compound found in turmeric, a spice known for its potent anti-inflammatory effects. In the gut, curcumin can help reduce inflammation and soothe the digestive lining. It may be particularly beneficial for individuals with inflammatory bowel diseases (IBD) or conditions characterized by gut inflammation. Curcumin’s anti-inflammatory properties can contribute to improved gut health and symptom management. [PMC5823546]
  • Ginger: Ginger is a well-known spice with anti-inflammatory properties and potential gut benefits. It has a long history of use for soothing gastrointestinal discomfort, such as nausea, indigestion, and bloating. Ginger’s anti-inflammatory effects can help reduce inflammation in the gut lining, making it a natural remedy for conditions like irritable bowel syndrome (IBS) and gastritis. Additionally, ginger may stimulate digestive enzymes, enhancing the digestive process and promoting overall gut health. [PMC9305072]
  • N-acetylcysteine (NAC): Oxidative stress can damage the gut lining. NAC is a rate limiting amino acid in the production of glutathione, the body’s master antioxidant. , which are essential for combating oxidative stress in the gut. Oxidative stress can damage the gut lining.
• Collagen: Collagen is a protein that makes up a significant portion of the gut lining. Supplementing with collagen may support the integrity of the gut lining, potentially helping to reduce intestinal permeability or “leaky gut.” A healthy gut lining is essential for proper digestion and nutrient absorption, and collagen can contribute to its maintenance. Bone broth is rich in nutrients like collagen, gelatin, amino acids, and minerals that are known to support gut health. These nutrients can help repair and maintain the gut lining, potentially reducing intestinal inflammation and improving digestive function. Bone broth is often recommended for individuals with digestive issues as it provides essential building blocks for a healthy gastrointestinal tract. [PMC9198822]
• Bovine Colostrum: Bovine colostrum is the early milk produced by cows, and it contains a rich array of nutrients and bioactive compounds. It is often promoted for its potential to help repair the gut lining. Colostrum contains growth factors, immunoglobulins, and other substances that may support gut health by promoting the growth and repair of the intestinal mucosa. Additionally, colostrum can have immunomodulatory effects, potentially helping to balance the immune response in the gut and reduce inflammation. [PMC9227274]
• Methylsulfonylmethane (MSM): MSM is a sulfur-containing compound found in certain foods and used as a dietary supplement. It may support gut tissue repair due to its sulfur content, which is essential for the synthesis of collagen and other structural proteins in the body. Collagen is a crucial component of the gut lining, and MSM may contribute to its maintenance and repair. Furthermore, MSM is believed to have anti-inflammatory properties, which can be beneficial for individuals with gut inflammation or conditions characterized by gut-related discomfort.
• Digestive Enzymes: Digestive enzymes break down food into smaller, absorbable molecules. They assist in the breakdown of proteins, carbohydrates, and fats, ensuring that nutrients are properly absorbed in the digestive tract. Supplemental digestive enzymes can help in the efficient digestion of food, potentially reducing symptoms like bloating, gas, and indigestion.

Are These Leaky Gut Supplements Safe?

These supplements, including L-Glutamine, Aloe Vera, Marshmallow Root, Deglycyrrhizinated Licorice (DGL), Slippery Elm Bark, Probiotics, Multivitamin, Omega-3 Fatty Acids, Berberine, Quercetin, Curcumin (Turmeric Extract), Ginger, N-acetylcysteine (NAC), Collagen, Bone Broth, Bovine Colostrum, Methylsulfonylmethane (MSM), and Digestive Enzymes, are generally considered safe when used as recommended. They have been extensively studied and have a track record of supporting gut health without significant adverse effects.

L-Glutamine, Aloe Vera, Marshmallow Root, Deglycyrrhizinated Licorice (DGL), Slippery Elm Bark, Probiotics, Multivitamin, Omega-3 Fatty Acids, Berberine, Quercetin, Curcumin (Turmeric Extract), Ginger, N-acetylcysteine (NAC), Collagen, Bone Broth, Bovine Colostrum, Methylsulfonylmethane (MSM), Digestive Enzymes

Medication Interactions

• Anticoagulants (e.g., Warfarin): L-Glutamine may enhance the anticoagulant effects of warfarin, potentially increasing the risk of bleeding. Aloe Vera may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Multivitamins containing vitamin K can interfere with the anticoagulant effects of warfarin.
• Antidiabetic Medications (e.g., Metformin): Berberine may lower blood sugar levels, potentially causing hypoglycemia when combined with antidiabetic medications like metformin.
• Blood Pressure Medications (e.g., ACE Inhibitors, Beta-Blockers): Ginger may have blood pressure-lowering effects, which could be additive when taken with blood pressure medications, potentially leading to low blood pressure.
• Cytochrome P450 Substrates (Various Medications Metabolized by CYP Enzymes): Berberine may interact with drugs metabolized by CYP enzymes, potentially affecting their levels in the body.
• Hormonal Contraceptives (e.g., Birth Control Pills): Ginger may affect the liver’s ability to process medications, potentially altering the efficacy of hormonal contraceptives.
• Warfarin: Marshmallow Root may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Deglycyrrhizinated Licorice (DGL) may enhance the anticoagulant effects of warfarin, potentially increasing the risk of bleeding. Slippery Elm Bark may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Multivitamins containing vitamin K can interfere with the anticoagulant effects of warfarin. Omega-3 fatty acids may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Quercetin may enhance the anticoagulant effects of warfarin, potentially increasing the risk of bleeding. Curcumin (Turmeric Extract) may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Collagen supplements may enhance the anticoagulant effects of warfarin, potentially increasing the risk of bleeding. Bone broth may have additive anticoagulant effects when used with medications like warfarin, increasing the risk of bleeding. Bovine colostrum may enhance the anticoagulant effects of warfarin, potentially increasing the risk of bleeding. Digestive enzymes can interfere with the anticoagulant effects of warfarin, potentially reducing its effectiveness.

Supplement Interactions

• L-Glutamine: Aloe Vera may enhance the soothing effects of L-Glutamine on the digestive tract, while Marshmallow Root’s mucilage properties can work synergistically with L-Glutamine to soothe and protect the gut lining. Deglycyrrhizinated Licorice (DGL) complements L-Glutamine’s role in supporting gut health, and Slippery Elm Bark’s mucilage content can enhance L-Glutamine’s effects in promoting gut comfort. Probiotics support a balanced gut microbiome alongside L-Glutamine, and Multivitamins provide additional nutrients for overall gut health in conjunction with L-Glutamine.
• Aloe Vera: Marshmallow Root’s mucilage content complements Aloe Vera’s soothing effects on the digestive tract, and DGL’s soothing properties may work in conjunction with Aloe Vera to protect the gastrointestinal lining. Slippery Elm Bark’s mucilage may enhance Aloe Vera’s ability to soothe and protect the digestive tract, while Probiotics support gut health alongside Aloe Vera.
• Marshmallow Root: DGL’s mucous-enhancing properties may work in conjunction with Marshmallow Root to soothe the digestive tract, and Slippery Elm Bark’s mucilage content can complement Marshmallow Root’s soothing effects on the gastrointestinal lining. Probiotics can contribute to gut health alongside Marshmallow Root, and Multivitamins may provide additional nutrients that support gut health in conjunction with Marshmallow Root.
• Deglycyrrhizinated Licorice (DGL): Slippery Elm Bark’s mucilage content may enhance DGL’s ability to soothe and protect the gastrointestinal lining, and Probiotics support gut health alongside DGL. Multivitamins may provide additional nutrients that support gut health in conjunction with DGL.
• Slippery Elm Bark: Probiotics can contribute to gut health alongside Slippery Elm Bark, and Multivitamins may provide additional nutrients that support gut health in conjunction with Slippery Elm Bark.
• Probiotics: Multivitamins may provide additional nutrients that support gut health alongside probiotics.
• Multivitamin: Omega-3 Fatty Acids complement the nutrients provided by multivitamins, and Collagen supplements may provide additional support to the nutrients in multivitamins for overall health. Bone Broth’s nutrient content may complement the vitamins and minerals in multivitamins.
• Omega-3 Fatty Acids: Collagen may support gut lining integrity alongside the anti-inflammatory effects of Omega-3 fatty acids, and Bone Broth’s nutrients may complement the benefits of Omega-3 fatty acids for gut health.
• Collagen: Bone Broth may provide additional collagen-related support for gut lining integrity.
• Bone Broth: Bovine Colostrum may complement the nutrients in bone broth for gut health, and Methylsulfonylmethane (MSM)’s potential support for gut tissue repair may work in conjunction with the nutrients in bone broth.
• Bovine Colostrum: Methylsulfonylmethane (MSM)’s potential to support gut tissue repair may complement the benefits of bovine colostrum, and Digestive Enzymes can assist in the efficient digestion of nutrients alongside bovine colostrum.
• Methylsulfonylmethane (MSM): Digestive Enzymes can aid in nutrient absorption and digestion, potentially enhancing the effects of MSM.
• Digestive Enzymes: Ginger’s potential to stimulate digestive enzymes may complement the action of digestive enzymes.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Nutrition Supplements for Leaky Gut

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

• Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
• Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
• Free shipping over $50.
• Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
• Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
• How It Works:
  • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
  • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
  • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Managing leaky gut is the first step towards improved overall health. It’s essential to understand the role of diet, lifestyle, and especially the best supplements for leaky gut in this journey. Armed with this knowledge, you are now ready to make informed decisions for your health. Remember, the path to wellness often begins with the gut. So, take a step forward today and explore the world of supplements that can support your journey towards better gut health.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.