DGL Supplements: A Powerful Stomach and Digestive System Ally

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Along with providing information on whether DGL supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

DGL, or deglycyrrhizinated licorice, is known for its potential benefits in alleviating gastrointestinal issues, supporting gut health, and more.

This article is designed to navigate the intricate world of DGL supplements, unveiling their properties, benefits, potential side effects, and the science behind how they work.

If DGL supplements are right for you, this article will show you the best place to order DGL online.

What Is DGL (Deglycyrrhizinated Licorice)?

Deglycyrrhizinated licorice, usually called DGL, is a type of licorice root that has had the glycyrrhizin component removed. Glycyrrhizin is a natural sweetener found in licorice that can have various health effects when consumed in large amounts, such as causing water retention and high blood pressure. By removing this component, DGL allows individuals to experience the potential benefits of licorice root without these side effects.

DGL is often used as a dietary supplement for various health benefits. It is traditionally used for gastrointestinal issues like stomach ulcers and heartburn because it’s believed to help increase the production of mucus in the stomach, providing a protective effect on the stomach lining.

What are the Benefits of DGL?

  • Helps with Stomach Problems: A study from 2014 found that DGL could stimulate mucus production. This additional mucus may serve as a protective layer against stomach and esophageal acid, aiding the healing of damaged tissue and helping to prevent acid reflux in the future. A later study in 2018 showed that DGL performed better than drugs specifically designed to suppress acid, backing up previous research findings.
  • Helps Heal Stomach Ulcers: DGL may help protect the lining of your stomach and intestines, which can prevent ulcers from forming or help existing ones heal. [PMC7348626]
  • Can Ease Symptoms of GERD: GERD stands for gastroesophageal reflux disease, a long-term condition where acid from the stomach comes up into the esophagus. DGL can help manage symptoms of GERD, like heartburn and a sour taste in your mouth.
  • Heals Canker Sores: Twenty people with mouth ulcers were told to use a mouthwash made from DGL and were tracked for two weeks. After just one day, 15 of these people saw their ulcers improve by 50-75%, and by the third day, the ulcers had completely healed. [PMID: 2632514]

Is DGL Safe?

DGL supplements are generally safe to use. The concern with licorice is the glycyrrhizin compound, which can cause side effects. DGL supplements remove it, so you get the benefits of licorice without the downsides.

Medication Interactions with DGL (Deglycyrrhizinated licorice)

  1. Blood Pressure Medications: Although DGL has the glycyrrhizin component removed, which is responsible for licorice’s blood pressure-raising effect, you should still use caution when taking it alongside blood pressure medication. Sourcing DGL from quality companies is key.
  2. Diuretics (Water Pills): Diuretics help your body get rid of excess water and salt. While the glycyrrhizin in licorice can cause the body to retain salt and water, it’s uncertain if DGL might still have some effect.
  3. Corticosteroids: Corticosteroids are used for conditions like arthritis or asthma. These can increase potassium loss from the body. While glycyrrhizin in licorice can lower potassium levels, it’s unknown if DGL might still have some effect. Consult your healthcare provider if you’re taking these medications. This interaction could be moderate to severe, depending on the specific medication and individual health status.

Supplement Interactions With DGL

  1. Potassium Supplements: Licorice, from which DGL is derived, can sometimes lower potassium levels in the body. While the component responsible for this effect (glycyrrhizin) is removed in DGL, you should still exercise caution when combining DGL with potassium supplements and source your DGL from reputable manufacturers.
  2. Supplements That Lower Blood Pressure: Again, while glycyrrhizin is removed in DGL, licorice is known to raise blood pressure. If you’re taking supplements that are intended to lower your blood pressure, combining them with DGL could possibly lessen their effectiveness. Here’s where it is important to source your supplements from a trustworthy supplier.

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Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

DGL Powder by Vital Nutrients

  • promotes healthy GI mucus secretion*
  • maintains healthy epithelial cells*
  • supports healthy cell function*

DGL Powder (deglycyrrhized licorice root) is soothing to, and provides nutritional support for, the gastrointestinal tract.* DGL significantly stimulates the proliferation of mucus secreting goblet cells.* It also aids in maintaining healthy epithelial tissue and helps to maintain normal cell function.*

Take 1/8 teaspoon, 3 times daily after meals, and at bedtime or as directed by a healthcare practitioner.

Amount Per 1/8 teaspoon Serving
DGL Powder … 300mg (deglycyrrhizinated licorice root)


DGL by Bioclinic Naturals

  • DGL chewable tablets is the form associated with the greatest clinical efficacy, as it allows for licorice to be released in the stomach and dispersed/absorbed by the gastric mucosa
  • Provides 400 mg DGL per tablet, the clinically effective dosage
  • Deglycyrrhizination prevents adverse effects associated with licorice consumption
  • Pleasant tasting tablets for better compliance
  • Suitable for vegetarians/vegans


Suggested Use: Chew 1 tablet per day 20 minutes prior to each meal, or as directed by a health care practitioner. Consult a health care practitioner for use beyond 16 weeks.

Amount Per 1 Tablet Serving:
Deglycyrrhizinated Licorice 10:1 Extract … 400mg
(Glycyrrhiza glabra) (root)
Providing 4, 000 mg crude herb licorice


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.


To Sum It Up

The power of natural supplements like DGL is hard to oversate. Deglycyrrhizinated Licorice provides a unique solution to those seeking to address digestive issues in a natural and holistic way. It stands as an intriguing testament to the benefits of combining traditional and modern health wisdom.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to reviews@supplement-sciences.com

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