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Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound that has attracted growing interest for its wide range of potential health benefits. Research suggests it may help support joint comfort, reduce inflammation, and promote overall resilience against everyday physical stressors. Because of these versatile applications, MSM has become a popular option for people looking to complement an active lifestyle or ease the wear and tear that comes with age.
If you’re considering adding MSM to your routine, this article will help you understand what the science says about how it works in the body, the benefits it may offer, and what to look for in a quality supplement. Supplement-Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements. In this article, we’ll show you the science behind MSM, exploring its benefits and how it works in the body.
What Is MSM (Methylsulfonylmethane)?
Methylsulfonylmethane (MSM) is a naturally occurring sulfur-containing compound found in small amounts in plants, animals, and the human body. Because natural intake is limited, it is also synthesized in laboratories and made widely available as powders, capsules, and other supplemental forms. Over the past two decades, MSM has drawn attention as a versatile dietary supplement, particularly for its potential to support joint comfort, exercise recovery, and overall resilience against everyday physical stressors.
Much of this interest stems from MSM’s well-documented anti-inflammatory activity. It has been extensively investigated in animal models and human clinical trials, where supplementation has been associated with reductions in inflammation, improvements in joint and muscle pain, enhanced antioxidant capacity, and mitigation of oxidative stress. Initial dose-finding studies suggest that up to four grams per day is generally well tolerated, and the substance is listed as “Generally Recognized As Safe” (GRAS), underscoring its favorable safety profile.
Since MSM has an enhanced ability to penetrate cell membranes and permeate throughout the body, its full mechanistic function likely involves multiple cell types and complex pathways, making it difficult to fully elucidate. Results from in vitro and in vivo studies indicate that MSM operates at the intersection of inflammation and oxidative stress at both the transcriptional and subcellular levels. Due to the small size of this organosulfur compound, distinguishing between direct and indirect effects remains challenging. In the sections that follow, we will examine these proposed mechanisms within a focused scope, highlighting how they may contribute to MSM’s observed effects.
Taken together, MSM stands out as a supplement with a solid foundation of evidence and a promising range of applications, even as research continues to clarify the details of its mechanisms, optimal dosing, and timing. ~PMC5372953
What Are the Benefits of MSM (Methylsulfonylmethane)?
Joint Health: MSM is often used as a dietary supplement to support joint health. It is believed to help reduce inflammation and pain associated with conditions like osteoarthritis. MSM may provide sulfur, which is essential for the formation of collagen, a key component of joints and connective tissues. [PMC5372953]
Anti-Inflammatory: MSM has anti-inflammatory properties and may help reduce inflammation throughout the body. This can be particularly beneficial for individuals dealing with chronic inflammatory conditions. [PMC5372953]
Hair and Skin Health: Some people use MSM supplements to promote healthy hair and skin. Sulfur, found in MSM, is important for the formation of keratin, a protein in hair and nails. MSM may help improve skin texture and reduce the appearance of wrinkles. [PMID: 32083522]
Allergy Relief: There is some evidence to suggest that MSM might alleviate allergy symptoms by reducing inflammation in the respiratory tract. It may also help improve the body’s response to allergens. A blinded trial of patients with allergic rhinitis showed that those who took MSM 1 gram/day for 14 days showed with low-dose treatments decreasing symptoms by 53%. Statisticians calculated that the chances of this being a fluke were one in 1000. [PMC6293242]
Exercise Recovery: Athletes and individuals engaged in physical activity sometimes use MSM to aid in post-exercise recovery. It is believed to reduce muscle soreness and promote tissue repair. [PMC3920715]
Detoxification: Sulfur, as found in MSM, is important for various detoxification processes in the body, particularly in the liver. [PMC5372953]
Food Sources of MSM (Methylsulfonylmethane)
Food Source
Amount of MSM per Serving
Cow’s Milk
3.3 mg per cup
Coffee
1.5 mg per cup
Tomatoes
0.6 mg per medium tomato
Corn
0.5 mg per ear
Tea (green/black)
1.2 mg per cup
Swiss Chard
3.6 mg per cup (cooked)
Alfalfa Sprouts
1.8 mg per cup
Asparagus
1.4 mg per 6 spears
Whole Grains (Oats)
1.5 mg per cup (cooked)
Beer
0.9 mg per 12 oz
Note: The amounts are approximate and can vary based on factors like soil quality and processing methods.
Are MSM (Methylsulfonylmethane) Supplements Safe?
MSM is safe for most people when taken at recommended dosages. It occurs naturally in the body and in many foods, making it a familiar compound to our systems. Numerous studies have tested MSM’s safety and found that it is well-tolerated, even at high doses. Side effects are rare but could include mild gastrointestinal issues like diarrhea or nausea. Overall, MSM has a strong safety profile and is commonly used without significant concerns for adverse effects.
Medication Interactions with MSM (Methylsulfonylmethane)
Blood Thinners (e.g., Warfarin): MSM may have a blood-thinning effect, which could enhance the action of anticoagulant medications.
Anti-inflammatory Drugs (e.g., Ibuprofen, Naproxen): MSM has anti-inflammatory properties and might interact with these medications, possibly amplifying their effects.
Diuretics (e.g., Hydrochlorothiazide): MSM can have a diuretic effect, potentially affecting the efficacy of other diuretic medications.
Chemotherapy Drugs: Some speculate that the antioxidant effects of MSM could interfere with the action of certain chemotherapy medications, although definitive research is lacking.
Supplement Interactions with MSM (Methylsulfonylmethane)
Glucosamine and Chondroitin: Often taken together for joint health, but combining them with MSM may amplify their effects.
Omega-3 Fatty Acids: Both have anti-inflammatory properties, so taking them together could heighten this effect.
Vitamin C: MSM improves the body’s ability to absorb nutrients, potentially enhancing the efficacy of vitamin C supplements.
Ginkgo Biloba: Both have blood-thinning effects and could interact if taken together.
Garlic and Ginger Supplements: These also have blood-thinning properties, so be cautious if combining with MSM.
Magnesium: Both MSM and magnesium can have a laxative effect, so taking them together may increase this outcome.
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MSM 1000 mg provides methylsulfonylmethane, an odorless form of organic sulfur that is naturally occurring in small amounts in fruits, vegetables, grains, and animals. In vitro studies have suggested that MSM may act as an antioxidant.* MSM supports normal tissue function.* MSM supplements may also promote joint health by supporting healthy mobility and function, as well as by maintaining normal joint comfort.* MSM 1000 mg may also help promote stable cell membranes, healthy inflammatory balance and colon health.*
Packaging and labels may vary.
Suggested Use: Take 1 capsule, twice daily, or as directed by your healthcare professional.
Amount Per capsuleServing Methylsulfonylmethane … 1000mg (MSM)
MSM Powder by NOW Foods
MSM (Methylsulfonylmethane) is a sulfur-bearing compound that is naturally present in very small amounts in fruits, vegetables, grains, animal products, and some algae. Sulfur compounds are found in all body cells and are indispensable for life.* MSM, in its role in the body’s sulfur cycle, helps to create the chemical links needed to form and maintain numerous different types of structural tissues of the human body, including connective tissues, such as articular cartilage and skin.*
Methylsulphonylmethane
Joint Sulfur for Connective Tissue*
Supports Healthy Cartilage*
Suggested Use:
Take 1/2 teaspoon 1 to 2 times daily in juice or other liquid. If intestinal gas occurs, reduce dosage.
Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Food is one of the “Pillars of Health”. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.
Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.
To Sum It Up
MSM supplements offer a variety of potential health benefits that many people find supportive. They’re often used to promote joint comfort, reduce inflammation, and improve skin health. As a naturally occurring compound with a good safety record, MSM can be a thoughtful addition for those looking to support overall well-being. While research continues to explore its full range of effects, it remains a promising option for maintaining everyday health and vitality.
This Article is Not a Substitute for Medical Advice
This information is provided for educational purposes only and is not a substitute for medical advice. Supplement Sciences does not provide medical care and cannot ensure the safety or effectiveness of any product for your personal use. Always consult your physician before starting any supplement, especially if you are pregnant, breastfeeding, or managing a serious health condition such as cancer, liver disease, or kidney disease. Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease.
* These statements have not been evaluated by the Food and Drug Administration.
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