Reversing Cardiovascular Disease: The Power of Lifestyle And Supplements For Heart Health

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In this article, we delve into the potential benefits of nutritional supplements in managing cardiovascular disease. Many people seek additional support beyond dietary changes and medications to maintain heart health. Understanding the role of supplements in cardiovascular care can provide valuable insights for those looking to optimize their well-being.

What Is Cardiovascular Disease?

Cardiovascular disease (CVD) encompasses a range of conditions that affect the heart and blood vessels, often leading to serious health complications. Commonly known as heart disease, CVD includes conditions such as coronary artery disease, heart failure, arrhythmias, and heart valve problems. Symptoms of cardiovascular disease can vary depending on the specific condition but may include chest pain or discomfort, shortness of breath, fatigue, dizziness, palpitations, and swelling in the legs, ankles, or abdomen. These symptoms often indicate underlying issues with blood flow to the heart or throughout the body. The causes of cardiovascular disease are multifactorial, with several risk factors contributing to its development. These risk factors include unhealthy diet, lack of physical activity, smoking, excessive alcohol consumption, high blood pressure, high cholesterol levels, obesity, diabetes, and family history of heart disease. Over time, these risk factors can damage the blood vessels and lead to the buildup of plaque, narrowing the arteries and restricting blood flow to the heart and other organs. This can ultimately result in heart attacks, strokes, or other serious complications. Understanding the symptoms and causes of cardiovascular disease is crucial for early detection and prevention, as lifestyle modifications and medical interventions can significantly reduce the risk of its progression.

What Food and Lifestyle Factors Are Important For Managing Cardiovascular Disease?

Managing cardiovascular disease involves adopting a heart-healthy diet and lifestyle to reduce risk factors and promote overall well-being. Incorporating nutrient-rich foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats, is essential for supporting heart health. These foods provide essential vitamins, minerals, antioxidants, and fiber, which help lower cholesterol, regulate blood pressure, and reduce inflammation. Additionally, limiting the intake of saturated fats, trans fats, cholesterol, sodium, and added sugars can help lower the risk of heart disease.

Regular physical activity is another crucial aspect of managing cardiovascular disease. Engaging in aerobic exercises, such as walking, jogging, swimming, or cycling, helps strengthen the heart, improve circulation, and control weight. Aim for at least 150 minutes of moderate-intensity exercise or 75 minutes of vigorous-intensity exercise per week, along with muscle-strengthening activities on two or more days per week.

Maintaining a healthy weight is also important for managing cardiovascular disease. Excess body weight, especially around the waistline, increases the risk of high blood pressure, high cholesterol, and diabetes. By adopting a balanced diet and staying physically active, it’s possible to achieve and maintain a healthy weight, reducing strain on the heart and blood vessels.

Other lifestyle factors that play a role in managing cardiovascular disease include quitting smoking, limiting alcohol intake, managing stress, getting an adequate amount of sleep, and regularly monitoring blood pressure, cholesterol levels, and blood sugar levels. By making these positive changes, people can effectively manage cardiovascular disease and reduce the risk of complications.


Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. This article aims to offer valuable insights into which nutritional supplements have undergone scientific study and shown promise in supporting specific health conditions. We break down the research, so you can work with your medical providers to make informed decisions about adding supplements to your health regimen. For personalized advice tailored to your needs, we recommend consulting with a registered dietitian in addition to your primary care provider.

Check with your physician when adding supplements. While supplements are generally safe for most people, do not add nutritional supplements without your physician’s specific approval if you are pregnant or nursing, are undergoing cancer treatment, have a history of organ transplant, liver or kidney disease, or take medications that interact with supplements.


  • Omega-3 Fatty Acids (Fish Oil): Known for their anti-inflammatory properties, omega-3 fatty acids EPA and DHA can help reduce triglyceride levels, lower blood pressure, and decrease the risk of arrhythmias. [PMC6806028]
  • Magnesium: Essential for heart rhythm, magnesium can help regulate blood pressure and is linked to a lower risk of coronary heart disease. [PMC5852744]
  • Taurine: An amino acid that may help lower blood pressure and improve heart function, particularly in individuals with heart failure. [PMC7551180]
  • Garlic: Some studies suggest garlic supplements can have modest benefits in lowering blood pressure and reducing arterial plaque buildup. [PMID: 26764327]
  • Fiber: Soluble fiber, found in supplements such as psyllium husk, can help lower cholesterol levels by binding to it in the digestive system and removing it from the body. [PMID: 35781477]
  • EGCg: EGCG was found to exhibit a wide range of therapeutic properties including anti-atherosclerosis, anti-cardiac hypertrophy, anti-myocardial infarction, anti-diabetes, anti-inflammatory, and antioxidant. Green Tea Extract is rich in antioxidants which help lower LDL cholesterol and improve overall heart health. [PMID: 28864169]
  • Curcumin: The active compound in turmeric, curcumin, has anti-inflammatory and antioxidant properties. Some research suggests it may improve endothelial function and reduce inflammation and oxidative stress associated with heart disease. [PMC10460800]
  • Berberine: This compound, found in several plants, has been shown to improve several cardiovascular risk factors, including high cholesterol, high blood sugar, and high blood pressure. [PMC9614282]
  • Niacin: Vitamin B3 at high doses, niacin can help increase HDL cholesterol and lower triglycerides, but its use should be closely monitored by a healthcare provider due to potential side effects.
  • Rhamnan Sulfate: This high-cost supplement has some early research in animal models to suggest this extract from green seaweed restores glycocalyx that lines and protects the blood vessels. Glycocalyx is destroyed by elevated blood sugar. [PMC8238147] Some unpublished research by Yong et al. from Drexel University also shows that it reverses plaque formation in mice by 60%. [*]
  • More:
    • Vitamin K2: This vitamin is believed to help prevent calcium deposits in the arteries, potentially reducing the risk of arteriosclerosis (hardening of the arteries).
    • Hawthorn Berry: Traditionally used for heart health, hawthorn berry may help improve heart function, increase exercise tolerance, and support healthy blood pressure.
    • L-arginine: This amino acid is involved in nitric oxide production, which helps relax blood vessels and improve circulation. However, its effectiveness and safety for heart disease patients require further study.
    • Coenzyme Q10 (CoQ10): This antioxidant may help lower blood pressure and improve heart function, especially in individuals taking statins, which can deplete CoQ10 levels.
    • Astaxanthin: A powerful antioxidant found in certain algae and seafood, astaxanthin has potential benefits for heart health, including improving arterial wall stiffness and reducing oxidative stress.
    • Selenium: An antioxidant that plays a role in preventing cell damage, selenium is thought to contribute to heart health, though excessive intake can lead to negative effects.
    • Omega-7 fatty acids (Palmitoleic acid): Emerging research suggests omega-7s may help reduce inflammation and improve lipid profiles, though more studies are needed.
    • Alpha-lipoic acid: Known for its antioxidant properties, alpha-lipoic acid may improve endothelial function and lower blood pressure. It is especially important for those with diabetes. [PMC7175430]
    • Folic acid (Vitamin B9): High levels of homocysteine, an amino acid in the blood, are linked to heart disease, and folic acid supplementation can help lower homocysteine levels.
    • Pycnogenol (French maritime pine bark extract): This supplement has been studied for its antioxidant properties and potential to improve blood flow and reduce inflammation.
    • L-Carnitine: Particularly in individuals with heart disease, L-carnitine supplementation has been explored for its potential to improve heart function and exercise capacity.
    • Plant Sterols and Stanols: These substances, which can be taken as supplements, help block the absorption of cholesterol in the gut, lowering LDL cholesterol levels.
    • Flavonoids (including Quercetin, Resveratrol): Found in many fruits, vegetables, and teas, flavonoids have antioxidant properties that may support heart health by improving endothelial function and reducing inflammation.
    • Vitamin D: Trials show several beneficial effects of vitamin D on the surrogate markers of vascular and cardiac function. [PMC7998446] but no benefit for preventing cardiovascular disease in the general population so far, although studies have not been done in deficient populations yet. Vitamin D dosages should be adjusted based on your blood level with many clinicians recommending an optimal Vitamin D level of 50-80 ng/ml. Vitamin D Labs (affiliate link) can be ordered in the NutriScape Lab Shop.

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Supplement Safety Information

Nutritional supplements can be a valuable addition to a comprehensive approach to managing cardiovascular diseases, offering potential benefits for heart health and overall well-being. It’s important to note that when used appropriately and under the guidance of healthcare professionals, many supplements are generally safe and well-tolerated. However, it’s crucial to exercise caution and consult with a healthcare provider before starting any new supplement regimen, especially for individuals with pre-existing medical conditions or those taking medications. By working closely with healthcare professionals and carefully selecting supplements supported by scientific evidence, individuals can enhance their cardiovascular health safely and effectively.

Medication Interactions:

  • Blood-Thinning Medications (e.g., Warfarin, Aspirin): Omega-3 fatty acids may enhance the effects of blood-thinning medications such as warfarin or aspirin, increasing the risk of bleeding.
  • Medications for Heart Rhythm Disorders (e.g., Digoxin): Magnesium supplements can interact with certain medications for heart rhythm disorders (arrhythmias), such as digoxin, potentially leading to irregular heartbeats.
  • Blood-Thinning Medications (e.g., Warfarin, Aspirin): Garlic supplements may increase the risk of bleeding when taken with blood-thinning medications like warfarin or aspirin.
  • Cholesterol-Lowering Medications (Statins): Niacin supplementation can enhance the effects of cholesterol-lowering medications known as statins, potentially increasing the risk of muscle-related side effects.
  • Blood-Thinning Medications (e.g., Warfarin): CoQ10 supplements may reduce the effectiveness of blood-thinning medications like warfarin, leading to decreased anticoagulant effects.
  • Blood Thinners (e.g., Warfarin): Vitamin K supplements, including K2, can interfere with the effectiveness of blood thinners like warfarin, as they help in blood clotting.
  • Medications for High Blood Pressure or Heart Failure: Hawthorn berry supplements may interact with medications for high blood pressure or heart failure, enhancing their effects and potentially leading to excessively low blood pressure.
  • Medications for Erectile Dysfunction (e.g., Sildenafil): L-arginine supplements may interact with medications for erectile dysfunction, such as sildenafil (Viagra), causing a sudden drop in blood pressure.
  • Cholesterol-Lowering Medications (Statins): Plant sterols and stanols supplements may interfere with the absorption of cholesterol-lowering medications, reducing their effectiveness.

Supplement Interactions:

  • Omega-3 Fatty Acids (Fish Oil): Omega-3 fatty acids may enhance the effects of garlic supplements, potentially increasing the risk of bleeding when taken with blood-thinning medications like warfarin or aspirin.
  • Magnesium: Magnesium supplements can interact with Coenzyme Q10 (CoQ10), potentially reducing the effectiveness of CoQ10 in improving heart function.
  • Garlic: Garlic supplements may interact with Vitamin K2, potentially reducing the effectiveness of Vitamin K2 in preventing calcium deposits in the arteries.
  • Niacin: Niacin supplementation can enhance the effects of Coenzyme Q10 (CoQ10), potentially increasing the risk of muscle-related side effects when taken with cholesterol-lowering medications known as statins.
  • Coenzyme Q10 (CoQ10): CoQ10 supplements may interact with Hawthorn Berry, potentially enhancing the effects of medications for high blood pressure or heart failure.
  • Vitamin K2: Vitamin K supplements, including K2, can interfere with the absorption of Plant Sterols and Stanols supplements, reducing their effectiveness in blocking the absorption of cholesterol in the gut.
  • Hawthorn Berry: Hawthorn berry supplements may interact with L-arginine, potentially enhancing the effects of medications for erectile dysfunction and causing a sudden drop in blood pressure.
  • L-arginine: L-arginine supplements may interact with Pycnogenol (French Maritime Pine Bark Extract), potentially enhancing the antioxidant properties of Pycnogenol.
  • Plant Sterols and Stanols: Plant sterols and stanols supplements may interfere with the absorption of Omega-7 Fatty Acids (Palmitoleic Acid), reducing their effectiveness in reducing inflammation and improving lipid profiles.
  • Pycnogenol (French Maritime Pine Bark Extract): Pycnogenol may interact with Alpha-lipoic Acid, potentially enhancing its antioxidant properties and improving endothelial function.
  • Omega-7 Fatty Acids (Palmitoleic Acid): Omega-7 fatty acids may interact with Flavonoids (Quercetin, Resveratrol), potentially enhancing their antioxidant properties and supporting heart health.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

What Lab Tests Might Be Helpful In Managing Cardiovascular Disease?

Several lab tests can be helpful in managing cardiovascular disease by assessing risk factors, monitoring disease progression, and guiding treatment decisions. These tests include:

  • Lipid Panel: Measures cholesterol levels, including total cholesterol, LDL cholesterol (bad cholesterol), HDL cholesterol (good cholesterol), and triglycerides. High levels of LDL cholesterol and triglycerides and low levels of HDL cholesterol are associated with increased cardiovascular risk.
  • High-Sensitivity C-Reactive Protein (hs-CRP): Measures inflammation in the body, which is linked to a higher risk of cardiovascular disease. Elevated levels of hs-CRP may indicate an increased risk of heart attack or stroke.
  • Blood Pressure Measurement: Checks blood pressure levels to assess the risk of hypertension, a major risk factor for cardiovascular disease. High blood pressure can strain the heart and blood vessels, increasing the risk of heart attack, stroke, and other complications.
  • Fasting Blood Glucose: Measures blood sugar levels after fasting overnight to assess the risk of diabetes or impaired glucose tolerance, which are both risk factors for cardiovascular disease.
  • Hemoglobin A1c (HbA1c): Provides an average of blood sugar levels over the past two to three months and is used to monitor long-term glucose control in individuals with diabetes.
  • Homocysteine: Measures levels of homocysteine, an amino acid in the blood. High levels are associated with an increased risk of cardiovascular disease, including coronary artery disease and stroke.

To Sum It Up

In conclusion, nutritional supplements offer promising benefits for managing cardiovascular disease and promoting heart health. From omega-3 fatty acids to magnesium and beyond, these supplements have shown potential in reducing inflammation, lowering cholesterol levels, improving blood pressure, and supporting overall heart function. However, it’s important to approach supplementation with caution and under the guidance of healthcare professionals, as interactions with medications and individual variations may affect their effectiveness. For personalized advice tailored to your specific needs and health goals, consider consulting a Registered Dietitian. They can provide evidence-based recommendations and support to help you make informed decisions about incorporating nutritional supplements into your cardiovascular health plan. Remember, while supplements can be a valuable addition to a healthy lifestyle, they should complement, not replace, balanced nutrition and regular medical care. Take charge of your heart health today by seeking further information and guidance from a trusted healthcare professional.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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