Antipsychotics (Abilify®, Haldol®, Seroquel®, Risperdal®, Zyprexa®): Drug-Nutrient Interactions To Know

Antipsychotic medications such as Abilify® (aripiprazole), Haldol® (haloperidol), Seroquel® (quetiapine), Risperdal® (risperidone), and Zyprexa® (olanzapine) are pivotal in treating psychiatric disorders. Their effectiveness and the patient’s nutritional status can be influenced by interactions with vitamins, minerals, and herbal supplements.

Drug-Nutrient Interactions:

• Vitamin D and Calcium: Antipsychotics, particularly those associated with weight gain and metabolic changes like Zyprexa® and Seroquel®, can impact bone density. Adequate intake of vitamin D and calcium is crucial for maintaining bone health, especially since some patients on long-term antipsychotic therapy may be at increased risk for osteoporosis. However, Vitamin D supplements reduce serum concentrations of antipsychotic medications, therefore monitoring of serum medication levels is recommended. [PMID: 35380747]
• B Vitamins: B vitamins, particularly folate (B9), B6, and B12, play roles in neurological function and mental health. Antipsychotics may influence the metabolism of these vitamins, potentially necessitating supplementation to support overall brain health and reducing side effects like fatigue or cognitive impairment.
• Magnesium: This mineral is vital for many bodily functions, including nerve transmission and muscle relaxation. Some antipsychotics may affect magnesium levels, leading to side effects such as muscle spasms or weakness, and supplementation might be beneficial in some cases.
• Omega-3 Fatty Acids: While not an herbal supplement, omega-3s are important for mental health and may interact with antipsychotic medications by potentially enhancing mood stabilization. However, they should be used cautiously and under medical supervision to ensure they don’t interfere with the therapeutic effects of the medications.

Herbal Supplement Interactions:

• St. John’s Wort: Known to affect the metabolism of many drugs, this herb can reduce the effectiveness of antipsychotics by increasing their breakdown in the liver, particularly relevant for drugs like Abilify® and Seroquel®.
• Other Herbals: Any herbal supplements should be carefully discussed with your physician because many interactions are possible. Don’t take supplements containing echinacea, evening primrose oil, ginseng or goldenseal without discussing the potential interactions with your pharmacist and physician.
• CBD Oil: Increasingly used for various health issues, CBD oil may alter the effects of antipsychotics or increase sedation levels.

General Recommendations:

It’s essential for individuals on antipsychotic medication to discuss any vitamin, mineral, or supplement use with their healthcare provider. This is especially important for vitamins and minerals that may be depleted or whose absorption might be affected by long-term medication use. Supplement changes should be made under professional guidance to avoid worsening side effects or reducing the effectiveness of the medication.

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