Antipsychotics (Abilify®, Haldol®, Seroquel®, Risperdal®, Zyprexa®): Drug-Nutrient Interactions To Know

Antipsychotic medications such as Abilify® (aripiprazole), Haldol® (haloperidol), Seroquel® (quetiapine), Risperdal® (risperidone), and Zyprexa® (olanzapine) are pivotal in treating psychiatric disorders. Their effectiveness and the patient’s nutritional status can be influenced by interactions with vitamins, minerals, and herbal supplements.

Drug-Nutrient Interactions:

  • Vitamin D and Calcium: Antipsychotics, particularly those associated with weight gain and metabolic changes like Zyprexa® and Seroquel®, can impact bone density. Adequate intake of vitamin D and calcium is crucial for maintaining bone health, especially since some patients on long-term antipsychotic therapy may be at increased risk for osteoporosis. However, Vitamin D supplements reduce serum concentrations of antipsychotic medications, therefore monitoring of serum medication levels is recommended. [PMID: 35380747]
  • B Vitamins: B vitamins, particularly folate (B9), B6, and B12, play roles in neurological function and mental health. Antipsychotics may influence the metabolism of these vitamins, potentially necessitating supplementation to support overall brain health and reducing side effects like fatigue or cognitive impairment.
  • Magnesium: This mineral is vital for many bodily functions, including nerve transmission and muscle relaxation. Some antipsychotics may affect magnesium levels, leading to side effects such as muscle spasms or weakness, and supplementation might be beneficial in some cases.
  • Omega-3 Fatty Acids: While not an herbal supplement, omega-3s are important for mental health and may interact with antipsychotic medications by potentially enhancing mood stabilization. However, they should be used cautiously and under medical supervision to ensure they don’t interfere with the therapeutic effects of the medications.

Herbal Supplement Interactions:

  • St. John’s Wort: Known to affect the metabolism of many drugs, this herb can reduce the effectiveness of antipsychotics by increasing their breakdown in the liver, particularly relevant for drugs like Abilify® and Seroquel®.
  • Other Herbals: Any herbal supplements should be carefully discussed with your physician because many interactions are possible. Don’t take supplements containing echinacea, evening primrose oil, ginseng or goldenseal without discussing the potential interactions with your pharmacist and physician.
  • CBD Oil: Increasingly used for various health issues, CBD oil may alter the effects of antipsychotics or increase sedation levels.

General Recommendations:

It’s essential for individuals on antipsychotic medication to discuss any vitamin, mineral, or supplement use with their healthcare provider. This is especially important for vitamins and minerals that may be depleted or whose absorption might be affected by long-term medication use. Supplement changes should be made under professional guidance to avoid worsening side effects or reducing the effectiveness of the medication.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Supplements For Anticonvulsant Users

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to

Leave a Reply