Acne: The Best Natural Supplements For Clear Skin

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Clear, healthy skin isn’t just about what you put on your face; it’s also about what goes into your body. While topical treatments and daily skincare routines are crucial, looking at acne from the inside out can make a big difference. This article will delve into how nutritional supplements can play a role in managing acne. We’ll look at what the science says about various supplements, giving you the information you need to make choices that support your skin health. Whether you’re dealing with occasional breakouts or more persistent skin issues, understanding the connection between nutrition and skin condition can help you take control of your acne in a more holistic way.

What Is Acne?

Acne is a widespread skin condition that affects many people, especially during adolescence, but it can continue into adulthood. This condition manifests as various types of blemishes, including pimples, blackheads, whiteheads, and sometimes painful cysts, primarily appearing on the face, neck, chest, back, and shoulders. Beyond causing discomfort, these blemishes can lead to lasting scars. Acne symptoms include raised, tender bumps, open pores with dark centers, closed pores with white bumps, and larger, inflamed lumps filled with pus.

While the exact causes of acne are complex and multifactorial, including factors like excessive oil production, bacterial growth, hormonal fluctuations, and genetic predisposition, nutrition also plays a significant role in skin health. Diets rich in certain nutrients can influence the skin’s condition, potentially exacerbating or alleviating acne. For example, low-glycemic foods, omega-3 fatty acids, and antioxidants are known to help reduce inflammation and improve skin quality.

Effective acne management involves not only topical treatments and appropriate skincare routines but also a strong focus on nutritional intake. Tailoring your diet to support skin health can be a crucial element in controlling acne. In severe cases, oral medications may be necessary, and consulting with a dermatologist for personalized care is recommended. This holistic approach, which combines skincare practices with nutritional strategies, is essential for maintaining healthy skin and preventing acne flare-ups.

What Food and Lifestyle Factors Are Important For Managing Acne?

  • Healthy Diet: A diet rich in fruits, vegetables, whole grains, and lean proteins provides essential nutrients that support skin health. Antioxidants found in fruits and vegetables help fight inflammation and promote healing, while lean proteins provide amino acids necessary for collagen production, aiding in skin repair and regeneration.
  • Hydration: Adequate hydration is crucial for maintaining skin elasticity and promoting cell turnover. Water helps flush out toxins from the body, preventing them from accumulating in the skin and could contribute to acne breakouts. Aim to drink at least eight glasses of water per day to keep the skin hydrated and healthy.
  • Regular Exercise: Exercise promotes blood circulation, delivering oxygen and nutrients to the skin while removing toxins and waste products. Additionally, physical activity helps reduce stress levels by triggering the release of endorphins, which can have a positive effect on acne. Incorporating activities such as walking, jogging, cycling, or yoga into your routine can benefit both your physical and mental health.
  • Proper Skincare: A gentle skincare routine is essential for managing acne-prone skin. Use non-comedogenic cleansers to remove dirt, oil, and impurities without clogging pores. Moisturize with oil-free or non-comedogenic moisturizers to keep the skin hydrated without exacerbating acne. Exfoliate regularly to remove dead skin cells and prevent pore blockages, but avoid over-exfoliating, which can irritate the skin and worsen acne.
  • Manage Stress: Chronic stress can trigger hormonal fluctuations that may exacerbate acne. Incorporate stress-reducing activities into your daily routine, such as meditation, deep breathing exercises, or mindfulness practices. Engaging in hobbies, spending time outdoors, or connecting with friends and family can also help alleviate stress and promote overall health.
  • Avoid Trigger Foods: While the relationship between diet and acne is complex and varies from person to person, some people may find that certain foods trigger or worsen their acne symptoms. Common trigger foods include dairy, high-glycemic index foods (such as sugary snacks and refined carbohydrates), and foods high in saturated fats. Pay attention to how your diet affects your skin and consider limiting or avoiding trigger foods to see if it improve your acne symptoms.
  • Adequate Sleep: Getting enough quality sleep is essential for skin and overall health. During sleep, the body repairs and regenerates skin cells, helping to maintain a healthy complexion. Aim for 7-9 hours of sleep per night, and establish a regular sleep schedule to support optimal skin health. If you struggle with sleep, try establishing a relaxing bedtime routine, limiting screen time before bed, and creating a comfortable sleep environment to promote better sleep quality.

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. This article aims to offer valuable insights into which nutritional supplements have undergone scientific study and shown promise in supporting specific health conditions. We break down the research, so you can work with your medical providers to make informed decisions about adding supplements to your health regimen. For personalized advice tailored to your needs, we recommend consulting with a registered dietitian in addition to your primary care provider.

Check with your physician when adding supplements. While supplements are generally safe for most people, do not add nutritional supplements without your physician’s specific approval if you are pregnant or nursing, are undergoing cancer treatment, have a history of organ transplant, liver or kidney disease, or take medications that interact with supplements.


  • Multivitamin: A high quality multivitamin will contain all of the following nutrients proven to support skin health.
    • Zinc: Dermatologists may suggest zinc supplements to aid in diminishing acne breakouts and promoting wound healing, as research shows that persons with acne frequently exhibit lower zinc levels, and zinc treatments can reduce inflamed pimples with minimal side effects. Zinc-rich sources: meat, shellfish, nuts, and seeds. PMID: 32860489
    • Vitamin A: Essential for skin health, dermatologists may prescribe vitamin A derivatives like retinoids for topical use or oral isotretinoin for severe acne cases. PMID: 36809126
    • Vitamin D: A study suggests that testing vitamin D levels in acne patients could be important for better prevention and treatment, as lower vitamin D levels were often associated with more severe acne. Additionally, ensuring sufficient vitamin D levels, whether through supplements or safe sun exposure, can support overall skin health and reduce inflammation linked to acne. PMC9154172
    • Vitamin E: As cited in a study involving 98 acne patients, researchers used a combination of vitamin E and vitamin C to target the buildup of skin cells in hair follicles, reducing acne formation by depriving bacteria of their food source. Additionally, vitamin E helped prevent skin irritation and inflammation caused by bacterial leakage. PMC4976416
    • Selenium: Selenium is an essential mineral known for its antioxidant properties, protecting the skin from oxidative damage and inflammation. Research suggests that selenium, in combination with vitamin E and zinc, is commonly used in acne therapy due to its antioxidant effects. Additionally, when combined with silymarin and N-acetylcysteine, selenium has been shown to reduce inflammation and acne lesions by regulating specific substances in the body. PMC8226785
    • Vitamin C: Vitamin C acts as an antioxidant, shielding the skin from environmental harm and boosting collagen production, which aids wound healing and diminishes acne scars. Additionally, its anti-inflammatory qualities, by inhibiting NFkB (a molecule that triggers inflammation), make it beneficial for acne and rosacea. It also contributes to wound healing and prevents dark spots post-inflammation. While vitamin C supplements are not typically used as the main treatment for acne, they can complement topical acne treatments and promote overall skin health. PMC3673383
  • Omega-3 Fatty Acids: Omega-3 fatty acids, recognized for their anti-inflammatory benefits, sourced often from fish oil, were shown in a study to diminish acne spots and inflammation in 45 persons with mild to moderate acne over a 10-week period. This suggests that incorporating omega-3 supplements could be beneficial in acne treatment without significant side effects. [PMID: 24553997]
  • Probiotics: Supporting gut health with probiotics may indirectly improve skin health by reducing inflammation associated with acne. [PMC8953587]
  • Green Tea Extract: Green tea contains polyphenols with antioxidant and anti-inflammatory properties that may help reduce acne-related inflammation and sebum production. Some studies suggest that green tea extract supplements or topical applications may be beneficial for acne treatment, although more research is needed to confirm their effectiveness. [PMID: 23096708] A study tested a green tea extract in women with post-adolescent acne, finding a decrease in acne lesions on specific facial areas after 4 weeks. PMC9370301
  • Other Botanicals: Many other botanicals have been used traditionally for acne. [PMC6273829]

The Gut-Skin Axis

The gut-skin axis describes the relationship between gastrointestinal health and skin condition, an emerging concept that offers new insights into managing skin issues like acne. This axis is grounded in the understanding that the gut and the skin share many common functions and are connected through various biological pathways, including immune responses and hormonal activity.

At the core of the gut-skin axis is the gut microbiome, the diverse community of microorganisms living in the digestive tract. The health of the microbiome can significantly affect skin health. An imbalance in this microbiome, known as dysbiosis, can lead to increased intestinal permeability, often termed “leaky gut.” This condition allows bacterial products and other pro-inflammatory substances to escape into the bloodstream and reach the skin, where they can trigger inflammation and exacerbate acne.

Moreover, a healthy gut microbiome aids in the proper digestion and absorption of nutrients that are critical for skin health, including antioxidants, vitamins, and minerals. These nutrients help to combat oxidative stress and inflammation in the skin, both of which are linked to acne flare-ups.

Probiotics are often discussed in the context of the gut-skin axis because they can help rebalance gut microbiota, reduce gut permeability, and support the immune system, all of which can positively influence skin health. Adopting a diet that supports gut health—rich in fiber, low in processed foods, and possibly supplemented with probiotics—can be an effective strategy to manage acne, illustrating the practical applications of the gut-skin axis in dermatological health.

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Are Supplements for Acne Safe?

These supplements, including Omega-3 Fatty Acids, Probiotics, Multivitamin/mineral supplements, Evening Primrose Oil, and Green Tea Extract, are safe for managing acne when used appropriately. Zinc and Omega-3 Fatty Acids are recommended for their anti-inflammatory properties, which can help reduce acne-related inflammation. Probiotics support gut health, indirectly benefiting skin health by reducing inflammation associated with acne. Vitamin D supports overall skin health and may help reduce acne-related inflammation.

Medication Interactions

  • Antibiotics: Zinc may interact with certain antibiotics, such as tetracyclines, reducing their absorption. It’s recommended to take zinc supplements at least 2 hours before or after taking antibiotics to avoid interference with absorption.
  • Blood Thinners (Anticoagulants): Combining omega-3 fatty acids, vitamin E supplements, or green tea extract with blood thinners like warfarin may increase the risk of bleeding, requiring close monitoring of clotting parameters during anticoagulant therapy.
  • Immunosuppressants: Probiotics and selenium supplements, when taken alongside immunosuppressive medications, may strengthen the immune system, possibly compromising the effectiveness of the medications. Close monitoring is advised in such cases.
  • Retinoids: Combining oral or topical vitamin A derivatives (retinoids) with vitamin A supplements may increase the risk of vitamin A toxicity, leading to symptoms such as headache, dizziness, nausea, and liver damage. It’s important to avoid excessive intake of vitamin A from multiple sources to prevent adverse effects.
  • Calcium Channel Blockers: Vitamin D supplements may enhance the effects of calcium channel blockers used to treat high blood pressure or heart conditions, possibly leading to excessively low blood pressure. Close monitoring of blood pressure is advisable when combining vitamin D supplements with calcium channel blockers.
  • Seizure Medications: Evening primrose oil may lower the seizure threshold and interact with anticonvulsant medications, which might reduce their effectiveness. Close monitoring by a healthcare professional is recommended when using evening primrose oil alongside seizure medications.
  • Antacids: High doses of vitamin C supplements may increase the acidity of the stomach, and could reduce the effectiveness of antacids used to treat acid reflux or ulcers. It’s advisable to take vitamin C supplements at least 2 hours before or after taking antacids to avoid interference with their absorption.

Supplement Interactions

  • Zinc: Zinc may enhance the absorption of omega-3 fatty acids, possibly increasing their effectiveness in reducing inflammation. Vitamin C may improve the absorption of zinc, leading to better utilization of both nutrients for immune function and skin health.
  • Omega-3 Fatty Acids: Omega-3 fatty acids may enhance the absorption of vitamin D, which is crucial for bone health and immune function. Omega-3 fatty acids and vitamin E work synergistically as antioxidants, helping to protect cells from oxidative damage.
  • Probiotics: Probiotics may support the absorption of vitamin D, contributing to overall bone health and immune function. Probiotics and vitamin C may have complementary effects on gut health and immune function when taken together.
  • Vitamin A: Vitamin A and vitamin D play complementary roles in immune function and may enhance each other’s effectiveness when taken together. Vitamin A and vitamin E may work synergistically as antioxidants, protecting cells from oxidative damage and supporting skin health.
  • Vitamin D: Vitamin D and vitamin K work together to regulate calcium metabolism and bone health, ensuring proper mineralization of bones and teeth. Vitamin D facilitates the absorption of calcium from the intestines, promoting bone health and muscle function.
  • Vitamin E: Vitamin E and selenium have synergistic antioxidant effects, protecting cells from oxidative damage and supporting immune function. Vitamin E and evening primrose oil may have complementary effects on skin health and inflammation when taken together.
  • Evening Primrose Oil: Evening primrose oil and omega-3 fatty acids may work synergistically to reduce inflammation and support skin health. Evening primrose oil and vitamin E may have complementary effects on skin health and inflammation when taken together.
  • Selenium: Selenium and vitamin E have synergistic antioxidant effects, protecting cells from oxidative damage and supporting immune function. Selenium and green tea extract may work together to enhance antioxidant activity and support overall health.
  • Vitamin C: Vitamin C may enhance the absorption of zinc, supporting immune function and skin health. Vitamin C and probiotics may have complementary effects on gut health and immune function when taken together.
  • Green Tea Extract: Green tea extract and selenium may work together to enhance antioxidant activity and support overall health. Green tea extract and omega-3 fatty acids may have complementary effects on inflammation and cardiovascular health when taken together.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

What Lab Tests Might Be Helpful In Managing Acne?

  • Hormone Levels: Testing for hormones such as testosterone, DHEA-S, and estrogen can help identify hormonal imbalances that may contribute to acne, especially in cases of hormonal acne or adult-onset acne.
  • Complete Blood Count (CBC): A CBC can provide information about white blood cell counts, which may show underlying inflammation or infection associated with severe acne or acne-related conditions like folliculitis.
  • C-reactive Protein (CRP): CRP levels may be elevated in persons with inflammatory acne, providing insight into the severity of inflammation and systemic effects.
  • Skin Swabs or Cultures: Dermatologists may perform skin swabs or cultures to identify specific bacterial strains present on the skin, helping guide antibiotic treatment for acne, especially in cases of severe or persistent acne.
  • Comprehensive Metabolic Panel (CMP): A CMP assesses various metabolic markers, including liver enzymes and blood glucose levels, which can provide insight into metabolic factors contributing to acne, such as insulin resistance.
  • Thyroid Function Tests: Testing thyroid function, including thyroid-stimulating hormone (TSH) levels, can help identify thyroid disorders that may be associated with acne or acne-like symptoms.
  • Vitamin and Mineral Levels: Testing for vitamin and mineral deficiencies, such as vitamin D, vitamin B12, and zinc, can identify nutrient imbalances that may contribute to acne development or exacerbation.
  • Skin Biopsy: In rare or severe cases, a dermatologist may recommend a skin biopsy to examine skin tissue under a microscope, providing additional information about the underlying mechanisms of acne and guiding treatment decisions.

To Sum It Up

The health benefits of Zinc, Omega-3 Fatty Acids, Probiotics, Vitamin A, Vitamin D, Vitamin E, Evening Primrose Oil, Selenium, Vitamin C, B Vitamins, and Green Tea Extract for acne management are significant. These supplements offer various mechanisms to support skin health, reduce inflammation, regulate sebum production, and promote wound healing, ultimately contributing to clearer, healthier skin. However, it’s essential to recognize that individual responses may vary, and these supplements should complement a well-balanced diet and skincare routine rather than serve as standalone treatments. Adopting a holistic approach to acne management, which includes dietary modifications, and proper skincare. By incorporating these strategies into your acne management plan, you can optimize your skin and overall health.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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