Corticosteroid Interactions: Calcium+D To Save Your Bones, Magnesium To Boost Effectiveness

Drug-Induced Nutrient Depletions

• Calcium: Corticosteroids can reduce calcium absorption, increasing the risk of osteoporosis and bone fractures. Calcium supplementation may be recommended to counteract this effect. [PMID: 8899087, PMID: 3728366]
• Vitamin D: These medications can alter vitamin D metabolism, further contributing to bone health issues. Supplementing with vitamin D can help maintain its optimal levels in the body. [PMID: 8967706]
• Magnesium: Corticosteroids may lower magnesium levels. A recent analysis found that long‐term magnesium supplementation of 350 mg/day improves glucocorticoid metabolism. [PMC7821302]

Supplement-Drug Interactions:

• Vitamin C: High doses of vitamin C might interact with the absorption or effectiveness of corticosteroids.
• St. John’s Wort: This supplement may reduce the effectiveness of corticosteroids.
• Potassium: Corticosteroids can cause potassium depletion. Supplementation or consuming potassium-rich foods may be necessary.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.