Spike: Discover Supplements That Help Degrade the Covid-19 Spike Protein

First, it’s important to fully acknowledge that there is no scientifically proven dietary supplement officially recognized for degrading or blocking the spike protein of viruses like SARS-CoV-2, the virus responsible for COVID-19. However, there are some studies of nutritional supplements showing that the spike protein from vaccines and Covid infections persist after Covid infection or vaccination and that they can be broken down with certain dietary supplements. The “McCullough Protocol” combines 3 supplements that have been shown to affect the spike protein.

It’s crucial to rely on evidence-based treatments and preventive measures for viral infections and consult healthcare professionals for advice on supplements and their effects on viral diseases. However, given the general lack of consensus, research data, and the absence of known harm from the proposed nutritional supplements, it seems reasonable to entertain the potential benefit of supplements on the basis of published theory alone. This article briefly discusses an emerging theory.

In addition, this article provides easy access to buy the McCullough Protocol supplements online through the secure Fullscript professional-grade online formulary at 20% off retail with free shipping.

The Problem With Spikes

Emerging research suggests that the SARS-CoV-2 spike protein might contribute to health problems, including cardiovascular and blood clotting injuries, after either COVID-19 infection or vaccination. [PMC9428332] Long-term detection of the spike protein in people with either “long-covid” or vaccine injury suggests it might have a role in prolonged symptoms. [PMC10452662]

Consequently, researchers have proposed a detoxification protocol targeting the spike protein. It features supplements including nattokinase, bromelain, and curcumin. Some researchers believe that this strategy might be used to help people with post-infection and post-vaccination complications. [PMC10663976] [McCullough, 2023]

A: Dissolution of spike protein-induced thrombus. Nattokinase directly degrades fibrinolysis-resistant fibrin (from spike protein), and bromelain upregulates fibrinolysis. B: Inhibition of spike protein via ACE2 receptors. Bromelain and curcumin block the ACE2 receptor, preventing spike protein from binding. C: Proteolytic degradation of spike protein. Nattokinase and bromelain degrade spike proteins, rendering them inactive. D: Attenuation of spike protein-induced inflammation. Bromelain and curcumin downregulate the NF-kB signaling pathway induced by spike protein, leading to the suppression of inflammatory molecules. E: BSD treatment protocol. The full treatment regimen and the addition of other compounds based on clinical indication are illustrated. Abbreviations: TPA = tissue plasminogen activator, PAI-1 = plasminogen activator inhibitor-1, ACE2 = angiotensin converting enzyme-2, NF-kB = nuclear factor kappa B, S1/S2 = spike protein subunits S1/S2, TLR4 = toll-like receptor 4.

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Order McCullough Protocol Supplements

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

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Order Nattokinase Supplements

The McCullough Protocol recommends a dose of 2000 FU nattokinase twice per day to break down blood clots.

Nattokinase by Ortho Molecular Products (60 count)

Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels.
1 soft gel capsule, one or two times per day or as recommended by your health care professional.

Amount Per 1 Softgel Serving
Nattokinase … 100 mg (2,000 Fibrinolytic Units)

Order Bromelain Supplements

The McCullough Protocol recommends a bromelain dose of 500 mg once per day to break down proteins, and reduce inflammation and blood clotting.

Bromelain 2400 GDU by Vital Nutrients

Bromelain is an enzyme found in pineapple stem, with a long history of use as a dietary supplement. Bromelain is considered a proteolytic enzyme due to its ability to break down protein when taken with food, although its benefits extend beyond digestion. When taken between meals, Bromelain helps support the body’s physiologic levels of kinins and fibrins, promoting healthy capillary blood flow to facilitate delivery of nutrients and removal of inflammatory waste products.* Bromelain is particularly useful for individuals interested in promoting normal sinus, tissue, and musculoskeletal health.*

Suggested Use: Take 1 capsule before each meal or as directed by your healthcare professional.

Serving Size: 1 Vegetarian Capsule

Amount Per Serving
Bromelain … 375mg

Other Ingredients: Vegetable Cellulose Capsule, Rice Powder, and Ascorbyl Palmitate.

Order Curcumin Supplements

The McCullough Protocol recommends 500 mg curcumin twice per day as an antiviral, anti-inflammatory and anti-fibrotic.

Curcumin 95 500mg by Jarrow Formulas

Provides Antioxidant Support*

  • Protects From Oxidative Damage*
  • 95% Active Curcuminoids
  • Quality & Value

Curcumin 95 is a concentrate of 95% curcuminoids, which are powerful antioxidants found in the spice turmeric. Specifically, curcumin and its derivatives help support antioxidant status and help minimize oxidative stress.*

Take 1 capsule per day with food or as directed by your qualified healthcare professional. 

Serving Size: 1 Capsule

Amount Per Serving
Turmeric Concentrate … 500mg
(Curcumin C33 Complex®)(Curcuma longa)(95% Total Curcuminoids)(Rhizome)

Research On The Possible Benefit of Green Tea (EGCG)

Although it is not part of the McCullough Protocol, there is some research having to do with other natural compounds inhibiting the binding of spike protein. A study explored the potential of epigallocatechin gallate (EGCG) from green tea to block the fusion of the COVID-19 virus spike protein with human cells. EGCG showed promise in blocking the interaction between the virus’s spike protein and the human cell receptor, possibly reducing infection and replication of the virus in cells. This finding highlights EGCG as a possible inhibitor of COVID-19 entry into cells. [PMC9278780] [PMID: 34375189] [PMC8290267]

Epigallocatechin gallate (EGCG) works by hindering the virus’s ability to attach to cell surfaces, specifically targeting the interaction with heparan sulfate proteoglycans, which are key for the virus’s entry into cells. This property of EGCG suggests its potential as a broad-spectrum agent against various coronavirus strains, including SARS-CoV-2 variants, by blocking their initial attachment to cells. [PMC9330937]

Order EGCG

EGCg 400mg by Protocol for Life Balance

One capsule of Protocol For Life Balance™ EGCg, 200 mg, possesses the phytonutrient content equal to about 2-3 cups of green tea.

Amount Per 1 Capsule Serving
Green Tea Extract … 200 mg (Camellia sinensis) (Leaf)
(Standardized Extract) [80% Total Catechins, and 50% EGCg (Epigallocatechin Gallate) (200 mg)](up to 4 mg of naturally occurring caffeine)
Decaffeinated Green Tea … 50mg (Camellia sinensis) (Leaf)

Research On The Benefit of Black Seed

Black Seed (Nigella sativa) is a natural food supplement that provides many documented antiviral compounds. [PMC7445151] Researchers report that molecular docking studies have shown that thymoquinone (a component of black seed) could block the COVID-19 virus by binding to the receptor-binding domain on the spike and envelope proteins of SARS-CoV-2. This may stop the virus entry into the cell and stop infection. [PMC8106451]

Black seed may also reduce the symptoms of Covid. A study found that 500 mg black seed oil supplementation was associated with faster recovery of Covid symptoms than usual care alone for patients with mild COVID-19 infection. [PMID: 36825730]

Black Seed Oil

Amount Per 1 Teaspoon Serving
 … 35
Calories from Fat … 35
Total Fat … 4g
Saturated Fat … 1g
Organic Black Cumin Seed Oil … 4.6g
(Nigella Sativa)

Suggested Use (Capsules):
Take two (2) capsules 1 to 2 times daily with food or as directed by a healthcare professional.

Serving size: 2 Capsules

Amount Per Serving
 … 10
Calories from Fat … 10
Total Fat … 1.5g
Black Cumin Seed Oil … 1300mg
(Nigella Sativa) [Supplying Thymoquinone (TQ)]

To Sum It Up

Recent studies suggest the spike protein of SARS-CoV-2, associated with COVID-19 infections as well as Covid vaccines, may lead to cardiovascular and blood clotting problems. The spike protein has been detected long after infection or vaccination, indicating a possible link to prolonged symptoms some people experience. As a response, a detoxification approach using nattokinase, bromelain, and curcumin is being considered. The McCullough protocol aims to target and break down the spike protein, potentially forming a vital part of treatment strategies for ongoing post-COVID-19 and vaccine-related complications. EGCg also has the potential to keep the spike protein from binding, thereby possibly helping reduce the risk of infection with a wide array of Covid subvariants.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

About the Author

Stephanie Figon, MS, RDN, LD

Founder of NutriScape.NET. As a dietitian since 1992, Steph Figon has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Connect on Linkedin

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