Supercharge Your Cells with PQQ: Boost Your Brain and Energy Levels

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As the scientific community continues to explore the world of dietary supplements, some compounds truly stand out for their unique health benefits. Pyrroloquinoline quinone, more commonly known as PQQ, is one such compound. Often referred to as a super-vitamin, PQQ has been generating excitement for its potential role in supporting mitochondrial health, brain function, and energy metabolism. If PQQ supplements are right for you, this article will show you the best place to order PQQ online. Supplement Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements at the best prices plus free shipping. In this article, we will delve into the science behind PQQ supplementation, shedding light on its health-promoting properties, the research backing these benefits, and how you might integrate PQQ into your wellness journey.

What Is Pyrroloquinoline Quinone?

Pyrroloquinoline Quinone, often abbreviated as PQQ, is a small molecule that’s quite important for health. Here’s why:

PQQ is a type of compound known as a cofactor. This means it helps certain enzymes (the substances that speed up reactions in our bodies) do their job properly. One of the big roles PQQ plays is in your body’s energy production. It assists in processes within your cells, specifically within tiny components called mitochondria, that produce create energy.

In addition, PQQ is considered an antioxidant. Antioxidants are really useful because they combat potentially harmful substances in your body called free radicals. Free radicals can damage your cells and contribute to aging and disease, so having antioxidants around to neutralize them is beneficial.

Some early research also suggests PQQ might support brain health. It may do this by promoting the growth and survival of new brain cells, which could have implications for memory and learning abilities. But remember, this research is still in its early stages, and more studies are needed to confirm these effects.

It’s important to note that PQQ is not traditionally produced by the human body. Therefore, we need to obtain it through our diet or supplements. Some food sources of PQQ include kiwi, spinach, and human breast milk. As for supplements, PQQ is often found in health stores, but it’s always recommended to consult a healthcare professional before starting any new supplement regimen.

What are the Benefits of PQQ?

  • Antioxidant Properties: PQQ is a redox cofactor that can undergo thousands of redox cycles without undergoing molecular breakdown. This allows it to neutralize reactive oxygen species (ROS), unstable molecules that can cause cellular damage, for an extended period. It essentially reduces cell damage that contributes to the aging process and various diseases.
  • Mitochondrial Biogenesis: PQQ has been observed to stimulate the creation of new mitochondria in cells. This process, called mitochondrial biogenesis, could potentially improve overall cell energy metabolism since mitochondria are the “powerhouses” of cells, producing energy in the form of ATP. So, PQQ plays a significant role in the process of cellular energy production. [PMC8115282] [PMID: 31860387] [PMID: 29185343]
  • Neuroprotective Properties: Some animal studies suggest that PQQ may offer neuroprotective benefits. This could potentially be due to its antioxidant activity and/or its influence on the production of nerve growth factor, which could impact cognitive health. [PMC8533503]
  • Neuroprotection and Brain Health: Preliminary research indicates that PQQ may support brain health. It could potentially promote the growth of new brain cells and help protect existing ones, which may be beneficial for cognitive functions like memory and learning.
  • Cardiovascular Health: There’s evidence to suggest PQQ could help protect the heart and circulatory system, potentially reducing the risk of heart disease and stroke.
  • Sleep and Fatigue: Some research suggests that PQQ may improve sleep quality and reduce fatigue, potentially by influencing important body rhythms and supporting energy metabolism.
  • Immune Function: As an antioxidant, PQQ can support the immune system’s function and help protect the body from illness and disease.
  • Inflammation Reduction: PQQ may have anti-inflammatory effects, which could help reduce inflammation in the body associated with various health conditions.
  • Covid Vaccine and Covid Related Heart Inflammation: “Spike protein-induced heart inflammation may originate from either COVID-19 infection or the administration of COVID-19 mRNA vaccines. As pyrroloquinoline quinone (PQQ) is a scavenger of free radicals, redox cofactor, and antioxidant which supports cognitive and mitochondrial functions, supplementation with PQQ could have a positive effect to reduce heart inflammation after COVID-19 mRNA vaccines. “[PMC8905048]
PQQ and cellular NAD+. A, niacin-related serum components are depicted that are important in the production of NAD+. Each interacts to generate NAD+ as indicated in the section encircled as B. PQQ plays a role in the process by enhancing the expression of nicotinamide phosphoribosyltransferase (designated as Nampt}. Increasing Nampt activity increases NAD+ cellular levels. NAD+ performs two principal functions; first, as a cofactor for dehydrogenases and reductases, such as lactic acid dehydrogenase (LDH), C, and second, as a co-substrate for sirtuin-catalyzed protein deacetylations as noted in D. Likewise, PQQ is a catalytic cofactor for LDH, C. PQQ facilitates the conversion of lactate to pyruvate. In the nucleus, E, NAD+, as a co-substrate for sirtuins, promotes targeted acetylation or deacetylation of proteins involved in cell signaling. Six examples are enumerated: (1) the LKBl/AMP-Kinase-pathway, important in the regulation of rnitochondriogenesis and rates of P-oxidation, (2) Forkhead box 0 transcription factors (FoxO) important to cellular proliferation and survival, (3) transcription factors involving NF-KB and P53 proteins, which regulate multiple aspects of innate and adaptive immune responsiveness, (4) the Janus kinase-signal transducer and activator of transcription JAK-STAT) pathway essential for processes related to hematopoiesis, lactation, and immune responsiveness, (5) peroxisome proliferator-activated receptor-gamma coactivator (PGC-lα), which plays a central role in cellular metabolism and ATP production and (6) the regulation of the mitochondrial transcription factor (TFAM) and other factors essential for mitochondrial genome replication. Finally, in the mitochondria, F. PQQ and NAD+ profoundly impact oxidative metabolism, ROS control, and heat regulation through events controlled by mitochondrial sirtuins and uncoupling proteins, such as UCP2.

Is PPQ Safe?

PQQ acts as an antioxidant and could potentially interact with medications that have antioxidant effects or affect the body’s oxidative processes. Here are a few examples:

  • Chemotherapy Drugs: Many chemotherapy drugs work by promoting the production of free radicals to kill cancer cells. Since PQQ is an antioxidant that neutralizes free radicals, it could theoretically reduce the effectiveness of chemotherapy treatments.
  • Anticoagulant/Antiplatelet Medications (like Warfarin or Aspirin): Some research suggests that PQQ might have blood-thinning effects, which could enhance the effects of anticoagulant or antiplatelet drugs. This could increase the risk of bleeding.
  • Antihypertensive Drugs: There’s some evidence that PQQ may help lower blood pressure. If you’re already taking medication to lower your blood pressure, PQQ could potentially enhance this effect, causing your blood pressure to drop too low.

Medication Interactions with Pyrroloquinoline Quinone

  • Coenzyme Q10 (CoQ10): CoQ10 and PQQ often work synergistically, meaning they can enhance each other’s effects. Both have antioxidant properties and play a role in energy production in the mitochondria of cells. Therefore, taking them together might amplify these benefits.
  • Antioxidant Supplements (like Vitamin C, Vitamin E, or Selenium): Since PQQ is an antioxidant, it might interact with other antioxidant supplements. This could potentially result in an excessive antioxidant effect, which while generally not harmful, in some situations might interfere with the body’s natural balance of antioxidants and free radicals.
  • Omega-3 Fatty Acid Supplements: Some preliminary research suggests that combining PQQ with Omega-3 fatty acids may have synergistic effects on brain function and heart health. But more studies are needed to confirm this.
  • Iron Supplements: In theory, because PQQ has antioxidant properties, it might interfere with the pro-oxidant effects of iron supplements. This means PQQ could potentially alter the effectiveness of iron supplements, but more research is needed in this area.

Food Sources of Pyrroloquinoline Quinone

The PQQ quantities in foods is measured in nanograms, which is orders of magnitude less than what is available in nutritional supplements, so it really can’t be obtained in any meaningful amount through the diet.

Order PQQ Supplements Online

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
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    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

PQQ Complex by Protocol for Life Balance

PQQ Complex is formulated for the support of optimal mitochondrial health and energy production.* PQQ (Pyrroloquinoline Quinone) is a vitamin-like nutrient that activates cell signaling pathways directly related to cellular energy production.* PQQ also promotes the formation of new mitochondria within cells and helps to protect mitochondria from free radicals generated during normal cellular respiration.*

PQQ Complex includes CoQ10 and Acetyl-L-Carnitine, two nutrients that also play critical roles in mitochondrial energy production.* As a dietary supplement, take 1 capsule daily, or as directed by your healthcare practitioner.

Amount Per 1 Capsule Serving
Vitamin B-12 …
 1000 mcg (as Methylcobalamin)
Acetyl-L-Carnitine … 200 mg (from Acetyl-L-Carnitine HCl)
Coenzyme Q10 (CoQ10) … 30 mg
BioPQQ® … 20 mg (Pyrroloquinoline Quinone) (as PQQ disodium salt)


PQQ by Solaray

PQQ (Pyrroloquiniline quinone) I intended to provide nutritive support for normal energy production in cells.
Use only as directed. Take one capsule daily with a meal or glass of water. Store in a cool dry place. 

Serving Size: 1 Capsule

Amount Per Serving
Pyrroloquinoline quinone disodium salt … 10mg (PQQ)


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

PQQ is a compound that holds promise for supporting cognitive function, cellular health, and overall vitality. Its benefits make it an intriguing addition to your wellness routine. If you’re considering incorporating PQQ into your daily regimen, it’s important to find a reputable source to purchase high-quality supplements. When it comes to where to buy Pyrroloquinoline Quinone online, look for trusted online retailers, health stores, or consult with healthcare professionals for personalized recommendations. Prioritize your health by obtaining PQQ from reliable sources to ensure its effectiveness and safety.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to reviews@supplement-sciences.com

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