Nattokinase

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Nattokinase is an enzyme derived from Natto, a traditional Japanese food known for its exceptional health benefits. In this article, we delve into Natto, unraveling its potential in promoting heart health, improving circulation, and its role in overall well-being. From understanding its origin and properties to looking at the latest research surrounding this potent enzyme, we’ve got you covered. If nattokinase supplements are right for you, this article will show you the best place to order nattokinase supplements online. Supplement Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements at the best prices. Let’s explore the power of this remarkable enzyme together.

What Is Nattokinase?

Nattokinase is an enzyme that is derived from a traditional Japanese food called natto, which is made from fermented soybeans. Enzymes are special proteins that speed up chemical reactions in the body.

Nattokinase has been studied for its potential health benefits, particularly for its ability to support healthy circulation and heart health. It works by breaking down a protein called fibrin, which is involved in the formation of blood clots. By breaking down fibrin, nattokinase may help prevent the formation of blood clots that can lead to heart attack and stroke.

Research on nattokinase is still ongoing, but some studies have suggested that it may also have other health benefits, such as supporting healthy blood pressure and cholesterol levels.

What are the Benefits of Nattokinase?

  • Heart Health: Benefits are due to its diverse beneficial effects like breaking down blood clots, lowering blood pressure and cholesterol, preventing atherosclerosis and offering neuroprotection, making it a promising candidate for CVD prevention and treatment.[PMC6043915]
  • Lowers blood pressure: A 2018 study of people with hypertension showed that nattokinase supplementation resulted in a small reduction blood pressure. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension. [PMID: 18971533]
Nattokinase Cutting Blood clots
  • Blood Clotting: Nattokinase acts as a blood thinner (antithrombotic) that works through multiple mechanisms. As shown in the image, one way nattokinase breaks up blood clots it to cut the fibrin links that hold blood clots together. [PMC5372539]
  • May Fight Covid Infection: Nattokinase has a degrading effect on the Covid-19 spike protein when it is mixed with cells in a laboratory. It has not yet been studied whether this would have any impact on real-world infection rates. [PMC9458005]

Is Nattokinase Safe

Nattokinase supplements, when taken as directed, are generally safe and well-tolerated by most people. However, it’s important to be aware of potential drug interactions and to be very careful about following your medical provider’s advice about adding nattokinase supplements to your regimen.

Nattokinase-Medication Interactions

  • Anticoagulant medications (such as Warfarin, Heparin, or Aspirin): Nattokinase may increase the risk of bleeding when taken with these medications. This can be a serious interaction, so it’s important to talk to your doctor before taking Nattokinase if you are already taking anticoagulant medication.
  • Antiplatelet medications (such as Clopidogrel or Ticlopidine): Natto may increase the risk of bleeding when taken with these medications. This can be a serious interaction, so it’s important to talk to your doctor before taking it if you are already taking an antiplatelet medication.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (such as Ibuprofen or Naproxen): Nattokinase may increase the risk of bleeding when taken with NSAIDs. This interaction is typically mild, but it’s still important to talk to your doctor before taking Nattokinase if you are already taking an NSAID.
  • Blood pressure medications: Nattokinase may have a mild blood pressure lowering effect, so it’s important to talk to your doctor before taking Nattokinase if you are already taking blood pressure medications.

Supplement Interactions with Nattokinase

  • Vitamin E: Nattokinase may increase the risk of bleeding when taken with high doses of vitamin E. It’s important to talk to your doctor before taking it if you are already taking vitamin E supplements.
  • Garlic: Garlic may also have a blood-thinning effect, so taking Nattokinase with garlic supplements may increase the risk of bleeding. It’s important to talk to your doctor before taking both supplements together.
  • Ginkgo Biloba: This supplement may also increase the risk of bleeding, so taking it with Nattokinase may increase the risk of bleeding. It’s important to talk to your doctor before taking both supplements together.
  • Fish oil supplements: fish oil supplements may also have blood-thinning effects. Taking Nattokinase with fish oil supplements may increase the risk of bleeding. It’s important to talk to your doctor before taking both supplements together.

Food Sources of Nattokinase

Nattokinase is derived from a traditional Japanese food called natto, which is made from fermented soybeans. However, the amount of Nattokinase in natto can vary widely depending on factors such as the fermentation process, the quality of the soybeans, and the preparation method. A 2 oz serving of Natto is estimated to have 2000-4000 fibriolytic units.

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Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Nattokinase by NOW Foods (120 count)

Amount Per 1 Capsule Serving

Nattokinase (2,000 FU) … 100mg**

(enzyme from Natto Extract) (Non-GMO soy derived)

Nattokinase by Ortho Molecular Products (60 count)

Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels.
1 soft gel capsule, one or two times per day or as recommended by your health care professional.

Amount Per 1 Softgel Serving
Nattokinase … 100 mg (2,000 Fibrinolytic Units)

To Sum It Up

Nattokinase has been recognized for its health benefits, particularly for heart health and circulation. It’s valued for its ability to dissolve blood clots and improve blood flow, which can be beneficial in managing conditions like high blood pressure and heart disease. Recently, an exciting discovery has suggested that Nattokinase may also have the ability to block the spike protein on COVID-19. It’s crucial to remember, though, that while these findings are promising, Nattokinase is not a substitute for professional medical advice or treatment.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to reviews@supplement-sciences.com

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