The Heart-Healthy Advantages of Nattokinase: What You Need to Know

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Along with providing information on whether Nattokinase supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans. Many people are intrigued by its potential health benefits, particularly in the areas of heart health and blood circulation. A growing body of scientific research is exploring how this enzyme may contribute to better well-being, from preventing blood clots to managing cholesterol levels. We will delves into what Nattokinase is and examines the evidence behind its claimed health advantages.

And if Nattokinase supplements are right for you, this article will show you the best place to buy Nattokinase online.

What Is Nattokinase?

Nattokinase is an enzyme extracted from natto, a traditional Japanese food that’s been part of the local diet for over a thousand years. Natto is made by fermenting boiled soybeans with a specific type of bacteria called Bacillus subtilis. The fermentation process gives rise to Nattokinase, which is a proteolytic enzyme, meaning it breaks down proteins. Nattokinase has garnered attention for its potential to improve various aspects of health, particularly cardiovascular health. This enzyme is also available in supplement form, making it easier for people to incorporate it into their wellness routines.

What Are the Health Benefits of Nattokinase?

  • Blood Pressure Control: Studies have indicated that Nattokinase can help in lowering high blood pressure levels. [PMC5066864]
  • Improved Circulation: Nattokinase promotes better blood flow, potentially leading to increased energy and less fatigue. In a controlled study, a single dose of 2,000 fibrinolytic units (FU) reduced the time it took for skin to warm up after cold water immersion. [PMC10362143]
  • Blood Clot Prevention: Research shows Nattokinase can help break down blood clots, reducing the risk of thrombosis. [PMC5372539]
  • Enhanced Fibrinolysis: This enzyme helps with fibrinolysis, the process of breaking down fibrin, a protein involved in clot formation.
  • Cholesterol Regulation: Some evidence suggests that Nattokinase can contribute to maintaining balanced cholesterol levels. [PMC6043915]
  • Anti-Inflammatory Properties: Limited studies point to the anti-inflammatory benefits of Nattokinase.
  • Reduced Stroke Risk: Due to its blood-thinning properties, it may lower the risk of stroke, although more research is needed. [PMC6043915]
  • Benefits in Stroke Management: A controlled trial in stroke patients showed nattokinase supplements to be beneficial. [PMC7415874]

Nattokinase and the Spike Proteins: Can This Supplement Prevent COVID-19?

In a study, researchers mixed Nattokinase with the S protein from the COVID-19 virus in test tubes. SARS-CoV-2 has a spike protein (S protein), and cleavage of the S protein is essential for viral entry. The results showed that Nattokinase broke down the spike protein. The more Nattokinase they used and the longer they let it sit, the more the S protein broke down. This led the researchers to question whether Nattokinase might help stop the virus from infecting cells. Of course, this is a very early-stage finding and more research is needed to see if it would work the same way in the human body. [PMC9458005]

Recent research has demonstrated that NK has potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects. 

Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases PMC6043915

Food Sources of Nattokinase.

Nattokinase is primarily found in natto, a fermented soybean dish that’s a staple in Japanese cuisine.

Food SourceNattokinase Content
Natto (Fermented Soybeans)20,000 FU (Fibrinolytic Units) per 100 grams

Are Nattokinase Supplements Safe?

Nattokinase is generally considered safe when used in moderate amounts, particularly as it comes from a food source—natto, a fermented soybean product that’s been part of the Japanese diet for centuries. While side effects are rare, they can include mild stomach upset or skin rash. It’s important to note that Nattokinase acts as a blood thinner, so people taking anticoagulant medications or with bleeding disorders should be cautious. Overall, Nattokinase has a long history of consumption, and no severe safety issues have been reported in the available scientific literature. [PMC8231931]

Medication Interactions with Nattokinase

  • Warfarin (Coumadin): Nattokinase has blood-thinning effects, so combining it with Warfarin could increase the risk of bleeding.
  • Aspirin: Similar to Warfarin, using Nattokinase along with aspirin might amplify the blood-thinning effects.
  • Clopidogrel (Plavix): Another blood thinner, combining it with Nattokinase may heighten the risk of bleeding.
  • Ibuprofen (Advil, Motrin): Being a nonsteroidal anti-inflammatory drug (NSAID), Ibuprofen can also thin the blood, which could be a problem when taken with Nattokinase.
  • Heparin, Dabigatran, Naproxen, and Ticlopidine: These are medications that may interact with Nattokinase, increasing the risk of bleeding.

Supplement Interactions with Nattokinase

These supplements are known for their blood-thinning properties and may interact with Nattokinase.

  • Garlic
  • Ginkgo Biloba
  • Ginger
  • Turmeric
  • Fish Oil
  • Vitamin E

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

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Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Nattokinase by Ortho Molecular Products

Manufacturer Description: Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels.
1 soft gel capsule, one or two times per day or as recommended by your health care professional.

Amount Per 1 Softgel Serving
Nattokinase … 100 mg (2,000 Fibrinolytic Units)

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

“To Sum It Up”

Nattokinase supplements offer several health benefits including better blood circulation, lower blood pressure, and improved heart health. Research backs these claims, making Nattokinase a subject of interest for its potential health advantages. As always, it’s important to be mindful of interactions with other medications or supplements you may be taking.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to

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