Hormone Replacement Therapy: Drug-Nutrient Interactions

Drug-Nutrient Interactions: 

  • Caffeine: The stimulating effects of caffeine may be increased due to inhibition of metabolism or clearance of caffeine by hormone replacement therapy.
  • Calcium and Vitamin D: Calcium and vitamin D may increase the absorption of hormone replacements. These supplements are recommended to improve bone mineral density during estrogen therapy. 
  • Red Clover Extract and Soy Isoflavones: These supplements may interfere with the activity or absorption of hormone replacement therapy.
  • St. John’s Wort: St. John’s wort may alter hormone metabolism including estrogen and progesterone. This supplement is not recommended during hormone replacement therapy. 

Drug-Induced Nutrient Depletion: Hormone replacement medications such as such as Estrace®, Premarin®,  Prempro® have been shown to deplete Folate, Vitamin B6, B12, and Magnesium. Bioidentical hormone replacement has been shown to deplete B6. [PMC5874849]

Suggested Nutrient Replacements:

  • Multivitamin: This will include Folate, Vitamin B6, B12 plus multiple other nutrients.

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