Hops

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Beyond their role in beer brewing, hops offer numerous health benefits gaining attention in wellness circles. From promoting relaxation to providing antioxidant support, hops supplements have become popular for their holistic properties. In this article, we’ll explore the science behind hops supplements, uncovering their potential to enhance overall health. Whether you’re curious about incorporating hops supplements into your routine or simply seeking to learn more about their benefits, join us as we explore the holistic advantages of hops supplements together.

What Are Hops?

Hops, the flowers from the Humulus lupulus plant, play a pivotal role in beer brewing, imparting unique flavors and aromas that distinguish various beer styles. These vine-grown flowers are more than just a brewing ingredient; they are a source of numerous natural compounds with potential health-promoting properties. The most notable substances found in female hop flowers include alpha acids, beta acids, essential oils, and flavonoids, each contributing to the plant’s therapeutic profile.

  • Alpha Acids: Primarily responsible for the bitter taste in beer, alpha acids have been studied for their antimicrobial properties, which can inhibit the growth of certain bacteria and fungi. This antimicrobial action suggests potential applications beyond brewing, possibly in natural preservative uses or alternative therapies for infections.
  • Beta Acids: Less bitter than alpha acids but equally significant, beta acids offer a range of medicinal properties, including anti-inflammatory effects. These compounds may help reduce inflammation in the body, potentially aiding conditions associated with chronic inflammation.
  • Essential Oils: The essential oils in hops, such as myrcene, humulene, and caryophyllene, contribute to the plant’s distinctive aroma and flavor. These oils are also thought to have calming and sedative effects, which have been utilized in traditional medicine to aid sleep and reduce anxiety.
  • Flavonoids: Hops are rich in flavonoids, a type of antioxidant that fights oxidative stress and free radical damage in the body. Flavonoids have been linked to numerous health benefits, including reduced risk of chronic diseases such as heart disease and cancer. They also support overall cellular health and may have anti-aging effects.

The synergy of these compounds in hops offers a broad spectrum of potential health benefits, making hops supplements a subject of interest for natural health enthusiasts. While traditionally celebrated for their role in brewing, the use of hops in supplements aims to harness these natural compounds for their antioxidant, anti-inflammatory, calming, and antimicrobial properties.

What Are the Benefits of Hops Supplements?

  • Antioxidant Properties: Hops are rich in antioxidants that neutralize harmful free radicals in the body, potentially decreasing the risk of developing chronic conditions such as heart disease and various forms of cancer. These antioxidants, including xanthohumol, contribute to cellular health and longevity by preventing oxidative damage to DNA, proteins, and lipids. PMC8868281
  • Anti-inflammatory Effects: The bioactive compounds in hops, such as humulones and lupulones, have demonstrated significant anti-inflammatory capabilities in research studies. These substances can mitigate the inflammatory process, potentially offering relief from symptoms associated with conditions like arthritis, inflammatory bowel disease, and other autoimmune disorders. PMC9603919
  • Sedative and Calming Effects: Hops contain natural sedative compounds, notably the flavonoid myrcenol, which can exert a calming effect on the central nervous system. This makes hops an effective natural remedy for reducing stress, promoting relaxation, and enhancing sleep quality, especially in individuals with insomnia or restless sleep patterns. PMC3399866
  • Menopausal Symptom Relief: Due to their phytoestrogenic properties, hops supplements have been explored for their ability to ease menopausal symptoms, such as hot flashes, night sweats, and hormonal imbalances. These estrogen-like effects can offer a natural alternative to hormone replacement therapies, with potentially fewer side effects. PMC5016504
  • Digestive Health Support: Hops contribute to digestive wellness through their bitter acids, which can stimulate bile production and enhance digestive enzyme activity. This can help improve digestion, reduce gastrointestinal discomfort, and alleviate common issues like indigestion, bloating, and gas.
  • Mood Enhancement: Preliminary research into the mood-enhancing properties of hops suggests they may help alleviate symptoms associated with anxiety and depression. This is thought to be due to their interaction with neurotransmitter systems involved in mood regulation, providing a natural means of improving emotional well-being. PMID: 28742505
  • Bone Health: Specific compounds in hops, such as prenylflavonoids, may support bone density and structure, potentially reducing the risk of osteoporosis. These effects are particularly beneficial for postmenopausal women, who are at a higher risk for bone density loss. PMC10304064
  • Weight Management: By promoting a sense of fullness and reducing appetite, hops can play a role in weight management strategies. This effect, coupled with potential metabolic benefits, might support weight loss efforts and help prevent obesity.
  • Skin Health: The antioxidant action of hops extends to skin protection, where they can defend against UV radiation and environmental pollutants. This helps prevent premature aging, promotes skin elasticity, and may reduce the appearance of wrinkles and age spots. PMC7396918
  • Respiratory Health: Hops exhibit bronchodilator properties, which can enhance lung function and ease breathing in individuals with respiratory conditions such as asthma and bronchitis. This may lead to improved respiratory health and a reduction in symptom severity.
  • Liver Support: The detoxifying effects of hops contribute to liver health by promoting the elimination of toxins and enhancing liver function. This supportive role is crucial for maintaining overall health and preventing liver-related diseases. Xanthohumol, found in hops, is a flavonoid known for its health benefits. It also plays a role in preventing and treating chronic liver disease by targeting processes like liver cell activation and fibrosis. Xanthohumol could potentially be used as a therapy to combat conditions such as obesity and fatty liver disease, making it a promising treatment option, especially for overweight patients. PMC4422013
  • Cognitive Function: With neuroprotective effects, hops may bolster cognitive function and guard against cognitive decline and neurodegenerative diseases. These benefits are linked to the anti-inflammatory and antioxidant properties of hops, which protect neural cells from damage. In a 12-week trial with 100 healthy older adults, supplementation with matured hop bitter acid (MHBA) capsules significantly improved attention, memory, and mood, suggesting potential benefits for cognitive function in aging populations. PMC7369117
  • Anti-cancer Properties: The compound xanthohumol, found in hops, has been studied for its ability to inhibit the growth of certain cancer cells. This offers a promising avenue for cancer prevention and supports the broader health benefits of hops in cancer risk reduction. PMC5972274
  • Blood Sugar Regulation: Hops help regulate blood sugar levels and improve insulin sensitivity, offering potential benefits for individuals with diabetes or pre-diabetic conditions. This regulation is crucial for maintaining energy levels and preventing long-term complications associated with diabetes. Isoxanthohumol (IX), found in beer hops, reduced weight gain, improved liver health, enhanced glucose metabolism by blocking fat absorption, and promoted a healthier gut environment by increasing beneficial bacteria like Akkermansia muciniphila. PMC10539672
  • Immune Support: By enhancing the body’s natural defense mechanisms through their antioxidant and anti-inflammatory properties, hops contribute to a stronger immune system. This can help reduce the frequency and severity of infections. Compounds found in hops, like xanthohumol (XN), can block key enzymes of the COVID-19 virus, which are necessary for its replication. PMID: 37976697
  • Heart Health: Hops have a beneficial effect on cardiovascular health, lowering blood pressure, reducing cholesterol levels, and improving the function of blood vessels. These combined effects contribute to a lower risk of heart disease and support overall cardiovascular wellness. Compounds like xanthohumol (XN), iso-α-acids (IAA), and matured hop bitter acids (MHBA) from hops can lower blood sugar, improve cholesterol levels, and help with weight management by influencing how our bodies process fats and sugars. PMC6151408

Are Hops Supplements Safe?

Hops supplements are safe when used as directed. Throughout history, hops have been used in various forms, including in beer brewing and herbal medicine, without reports of significant side effects when consumed in moderation. These supplements are carefully formulated to contain specific compounds like alpha acids and flavonoids, which are known for their health benefits. While rare, some persons may experience mild side effects like digestive discomfort or allergic reactions. To ensure safety, it’s important to purchase hops supplements from reputable manufacturers and follow recommended dosage instructions. Overall, hops supplements can be a safe and natural way to promote relaxation, improve sleep quality, and support overall health.

Medication Interactions with Hops Supplements

  • Sedatives or Sleep Medications: When taken with hops supplements, sedatives or sleep medications may lead to enhanced drowsiness or dizziness. This combination can also increase the risk of slowed breathing, especially if alcohol or other central nervous system depressants are also consumed.
  • Anti-anxiety Medications: Combining hops supplements with anti-anxiety medications can intensify sedative effects, resulting in increased drowsiness and impaired coordination. Additionally, this combination may lead to slowed breathing, particularly in persons with respiratory conditions.
  • Blood Pressure Medications: Hops supplements have been found to lower blood pressure. Taking them alongside blood pressure medications could possibly cause a significant drop in blood pressure, which may lead to fainting or other complications.
  • Antidepressants: Some antidepressants can increase serotonin levels in the brain. When hops supplements are taken with these medications, there’s a risk of developing serotonin syndrome, a serious condition characterized by agitation, confusion, rapid heart rate, and high blood pressure. This combination may also result in enhanced drowsiness and slowed breathing, especially when combined with other medications or substances.
  • Anticoagulants or Antiplatelet Medications: Hops supplements have mild blood-thinning effects. Combining them with anticoagulants or antiplatelet medications may increase the risk of bleeding or bruising. While this interaction may not directly cause enhanced drowsiness or slowed breathing, it’s essential to monitor for signs of excessive bleeding.
  • Hormonal Medications: Hops supplements contain compounds with estrogen-like effects. When taken with hormonal medications such as birth control pills or hormone replacement therapy, they may interfere with hormone levels or effectiveness. While this interaction may not directly cause enhanced drowsiness or slowed breathing, it could lead to hormonal imbalances or other adverse effects.

Supplement Interactions with Hops Supplements

  • Melatonin: When combined with hops supplements, melatonin may intensify sedative effects, leading to excessive drowsiness. This combination is commonly used to promote relaxation and sleep, but caution is advised, especially when driving or operating machinery.
  • Valerian Root: Hops supplements and valerian root both have mild sedative properties. Taking them together can enhance relaxation and drowsiness. This combination is used to alleviate anxiety and promote sleep, but it’s important to use them cautiously.
  • Kava Kava: Combining hops supplements with kava kava may increase sedation and impair coordination. Caution is advised, especially when consuming alcohol or other depressants.
  • St. John’s Wort: Taking hops supplements with St. John’s Wort may increase the risk of serotonin syndrome. It’s crucial to avoid this combination and consult with a healthcare professional.
  • GABA (Gamma-Aminobutyric Acid): Combining hops supplements with GABA can enhance relaxation and reduce anxiety. Start with a low dose and monitor for any adverse effects.
  • L-Theanine: Hops supplements and L-theanine promote relaxation. Combining them can intensify these effects, leading to enhanced relaxation and drowsiness.
  • 5-HTP (5-Hydroxytryptophan): Taking hops supplements with 5-HTP may increase the risk of serotonin syndrome. Avoid this combination and consult with a healthcare professional.
  • Passionflower: Combining hops supplements with passionflower can enhance relaxation and promote sleep. Start with a low dose and monitor for adverse effects.
  • Chamomile: Hops supplements and chamomile reduce anxiety. Combining them can intensify relaxation and drowsiness. Start with a low dose and monitor for adverse effects.

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Hops Flowers by Nature’s Way

Hops are traditionally used for nervous system support. Suggested Use: Take 2 capsules daily with food or a full 8 ounce glass of water.

Amount Per 2 Veg Capsule Serving

Hops … 620mg (flower)

Calocurb Amarasate Appetite Control by Calocurb

The Primary Ingredient: Amarasate (Am-ar-eh-sate) is an extract from hops. Amarasate works by helping stimulate tastebuds in the gut to release hormones, which send a natural fullness signal to the brain to help manage appetite. *

Effective Appetite Management: Calocurb is a world-first, patented formula that helps support the healthy management of appetite, intermittent fasting, overeating, and hunger so you can feel confident about healthy eating. * Use in conjunction with a balanced diet and exercise.

What to Expect: Calocurb may help to stimulate your body’s natural GLP-1 production. * GLP-1 is a hormone that causes feelings of satiety and can also have side effects including a laxative effect, cramps, indigestion, or burps. . Each person’s digestive system is different. If you experience unwanted side effects, decrease dosage until issues subside.

Naturally Derived: Calocurb is a plant-based, GMO-free, vegan appetite support supplement. * It contains no sugar, no caffeine, and no stimulants. It should not cause any jitters or bloating or disrupt your sleep. Clinically studied: Calocurb has been shown to help reduce appetite by 80% and decrease calorie intake by 18%. * 

Suggested Use:
Day 1-2: Take 1 capsule an hour before a meal.
Day 3-4: Take 1 capsule twice daily, one hour before meals.
Day 5+: Take 2 capsules twice daily, one hour before lunch and dinner.
Max: 4 capsules daily. Always take on an empty stomach.

Amount Per Two (2) capsule Serving
Amarasate™ extract … 250mg
(New Zealand Hops Flower Extract)

Other Ingredients: Canola oil to improve absorption, Rosemary leaf extract, Delayed release vegetarian capsule (hypromellose).

See Professional Information on Calocurb.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Incorporating hops supplements into your wellness regimen can provide various health advantages. From aiding relaxation and enhancing sleep quality to offering antioxidant support, hops supplements offer a natural method to boost overall health. Whether you seek relief from anxiety or insomnia symptoms or simply desire a gentle way to unwind, hops supplements are worth considering. With their extensive history of use in traditional medicine and brewing, hops offer a tried-and-true approach to improving your health and energy. So, why not explore the potential benefits of hops supplements and see what they can offer you?


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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