Nature’s Mood Lifters: Exploring Effective Supplements For Depression Relief

Nutritional supplements are complementary approaches to depression management and mental wellness. Although prescription antidepressants may be vital in handling depression, certain dietary supplements have been shown to be effective as well. Vitamins, minerals, and other natural constituents act on brain chemistry and influence mental health. 

If any of these supplements are right for you, this article will show you the best place to buy them online. Supplement-Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements. This article explores specific supplements that have scientific evidence to back them up in how they can work along with other therapies to give the complete approach to alleviating depression and low mood.

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. This article aims to offer valuable insights into which nutritional supplements have undergone scientific study and shown promise in supporting specific health conditions. We break down the research, so you can work with your medical providers to make informed decisions about adding supplements to your health regimen. For personalized advice tailored to your needs, we recommend consulting with a registered dietitian in addition to your primary care provider.

Check with your physician when adding supplements. While supplements are generally safe for most people, do not add nutritional supplements without your physician’s specific approval if you are pregnant or nursing, are undergoing cancer treatment, have a history of organ transplant, liver or kidney disease, or take medications that interact with supplements.

Beyond Drugs And Supplements: Critical Elements For Improving Mood and Dealing With Depression

Depression is a complex and multifaceted condition. It requires a comprehensive approach to management. Key elements in improving mood and dealing with depression extend beyond traditional medication and therapy. Before we dive into the benefit of nutritional supplements for improving mood, it’s important to acknowledge that our mental health needs a more complete approach than medications and nutritional supplements can provide.

  • Exercise: Lifestyle changes play a crucial role. Regular physical activity, ranging from light walks to more intensive exercises, can trigger the release of endorphins, boosting mood and reducing stress. Similarly, prioritizing sleep is essential, as poor sleep quality can exacerbate depressive symptoms. Establishing a consistent sleep routine and creating a restful environment are key strategies in this regard. PMC2702700
  • Stress management: Techniques, such as mindfulness meditation, yoga, and deep breathing exercises, are effective in mitigating the impact of stress on mood. These practices not only help in calming the mind but also bring a sense of control and self-awareness, which is often compromised in depression.
  • Diet: A diet rich in fruits, vegetables, whole grains, lean protein, and healthy fats can provide the necessary nutrients for brain health and mood regulation. Conversely, a diet high in processed foods, sugar, and unhealthy fats can have a very negative effect on mood. [PMID: 37149054] The effectiveness of nutritional approaches has been under-recognized and underutilized in the treatment of depression. [PMID: 21244124]
  • Social support: cannot be overstated. Building and maintaining a support network, whether through friends, family, support groups, or therapy, provides emotional support crucial for navigating the challenges of depression.

Nutrition Counseling From Registered Dietitians- The SMILES Trial

A study called “SMILES” explored whether changing what people eat can help treat depression. This study randomly assigned people with moderate to severe depression to either received dietary advice from a dietitian, or receive group social support without any dietary advice. Both groups met for seven sessions.

The main goal was to see if there were any changes in depression symptoms after 12 weeks. They also looked at other things like mood changes and anxiety levels. Most of the participants were already receiving some form of depression treatment, like therapy or medication.

The results were interesting. The group that got dietary advice showed a much better improvement in their depression symptoms compared to the group that just got social support. About one-third of the people in the dietary advice group saw their depression symptoms reduce to a level that could be considered remission, whereas only a small portion of the social support group reached this level.

The study’s findings suggest that improving your diet could be a useful and reachable way to manage depression. This could also help with other related health issues. The results were strong enough that the researchers believe the positive effects of the diet change were not just due to chance or other factors.

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial) [PMC5282719]

Caution: Switching From Antidepressants Can Be Risky

Each person is unique and while it is desirable to seek out natural approaches for health, it’s also important to acknowledge that depression can be very serious and withdrawal from prescription antidepressants can be particularly tricky. Don’t go it alone. Consult your physician. Here’s why:

Firstly, antidepressants are prescribed based on a thorough evaluation of the individual’s specific mental health needs, and abrupt changes can lead to a sudden worsening of symptoms.

Secondly, dietary supplements, although generally effective in many cases, are not as rigorously tested for efficacy and safety as prescription medications. Some of them interact with existing medications or health conditions so their effects can be unpredictable.

Thirdly, stopping antidepressants suddenly can cause withdrawal symptoms which can be both uncomfortable and potentially harmful. Your physician can provide guidance on the appropriate course of action, considering your medical history, the nature of your depression, and the specific properties of your current medication.

What Are The Advantages of Dietary Supplements For Relieving Depressed Mood?

Antidepressant dietary supplements possess several advantages that resonate with people seeking natural and holistic approaches to the mental domain. For many people, these plant-based, fish oil, or mineral-based supplements serve as an alternative to prescription drugs. These also have minimal or milder side effects so they are preferred many people. 

Besides, the same supplements will play additional role which can increase efficiency of traditional anti-depression pills so that some people may be able to decrease their prescription dosage. They also have nutritional side benefits that promote wellness like enhanced cognitive function and increased sleep quality.

Many supplements have been studied for their effects on mood and have been found to be effective. These include Omega-3 Fatty Acids, St. John’s Wort, S-Adenosylmethionine (SAMe), 5-HTP (5-Hydroxytryptophan), Vitamin D, Magnesium, Probiotics, Zinc, B Vitamins (especially B6 and B12), Folate, L-Theanine, Rhodiola Rosea, Ashwagandha, Turmeric/Curcumin, and Ginkgo Biloba. Read on to find out how each of these can make a difference in mood.

Antidepressant Effects of Omega-3s

Omega three fatty acids are typically found in fish oils and some plant oils. These have a very crucial part in cognitive functioning as they are critical to brain health and regulation of mood. These are necessary fats that constitute cell membranes in the brain and participate in different kinds of brain activity like neurotransmission. Omega-3s are thought to affect the neuronal pathways involving serotonin and dopamine, both of which are associated with mood. A 2023 randomized trial showed that depression scores were lower in people taking omega 3, with or without the addition of prescription antidepressants. [PMC9962071]

Also, omega-3 fatty acids are anti-inflammatory, and inflammation has been correlated with depression. Omega-3s can reduce inflammation and enhance brain cell structures and functions leading to enhanced mood and better mental health. The regular consumption of Omega-3 fatty acids, particularly the DHA and EPA found in fish oil, contributes to better brain health. In turn, this is related to psychological and emotional wellbeing. So, whether you are supplementing with fish oil or eating lots of high omega 3 fish (Salmon, Mackerel, Sardines, Anchovies, or Herring-the SMASH fish), your brain health will benefit.

Read the details in our article: Omega-3: Why Fish Oil Is One of The Most Important Supplements.

Antidepressant Effects of Vitamin D

One of the most well-known vitamins is Vitamin D, often referred to as the sunshine vitamin, for regulating one’s mood and mental health. It is obtained through diet and supplements and is also uniquely produced by the body when the skin is exposed to sunlight. Vitamin D receptors are found all over the brain, which shows its importance in brain function. Research has revealed that deficiencies in Vitamin D are associated with high risks of mood disorders, including depression because it is believed to affect the synthesis of mood-modulating neurotransmitters like serotonin. Vitamin D is also involved in neuroplasticity, i.e. growing new brain cells and connections, which is essential for the mental health.

Dietary intake, supplementation and natural sunlight can adequately maintain levels of Vitamin D. Vitamin D synthesis is naturally stimulated by sunlight exposure. Consult a healthcare provider for personalized information, including the necessary sunlight, diet, and supplementations for unique health requirements. [PMC6970300]

Read more in our article: Vitamin D: Bridging the Gap Between Sunlight and Supplements.

Antidepressant Effects of Probiotics

We usually think of probiotics as being known for their benefits to gut health, but research has been discovering the effects of certain probiotics for their potential impact on mood and mental well-being. The concept of the “gut-brain axis” illustrates how the gastrointestinal system and the brain communicate with each other, influencing mental health.

Probiotics, which are beneficial bacteria, can play a role in this communication. They help maintain a healthy gut environment, which is essential for the absorption of nutrients that are vital for brain health, including those involved in neurotransmitter synthesis. Moreover, a healthy gut microbiome is linked to reduced inflammation throughout the body, including the brain.

Since inflammation is a known contributor to some forms of depression, reducing it can have positive effects on mood. Additionally, some strains of probiotics are believed to produce neurochemicals directly, such as GABA and serotonin, which are crucial for mood regulation. While research is still ongoing, current studies suggest that supplementing with probiotics can be a valuable part of a holistic approach to improving mood and managing symptoms of depression. However, it’s important to note that probiotics are not a standalone treatment for mood disorders and should be considered as part of a broader, comprehensive approach to mental health. [PMC7915600]

Read more in our article: Bacteria as Allies: Exploring the Long List of Probiotic Benefits.

Antidepressant Effects of Zinc

Zinc, a vital mineral, plays an integral role in mental health, particularly in mood regulation and the management of depression. Its importance is underscored by the fact that a significant portion of the population, estimated to be around 12% in the United States, might have a dietary zinc deficiency. This deficiency is more common in specific groups, including older adults, vegetarians, and individuals with gastrointestinal disorders, all of whom may have difficulty obtaining or absorbing enough zinc from their diets.

Zinc is crucial for neurotransmitter function and stress response modulation in the brain. Low zinc levels are often linked to an increased risk of depression, as the mineral helps reduce brain inflammation and oxidative stress, which are elevated in depressive states. [PMID: 32829928]

It also plays a role in the neural pathways that regulate mood and aids in the synthesis of serotonin. While supplementing with zinc can be beneficial, especially in those with deficiencies, and has shown potential in enhancing the efficacy of antidepressants, it’s important to balance intake carefully. Excess zinc can lead to adverse effects, so be careful not to take excessive supplements.

Read more in our article: Zinc: This Immune Standby May Also Improve Mood and Blood Glucose


Magnesium plays a pivotal role in brain chemistry and its impact on mental health, particularly in the context of depression. Magnesium is crucial for numerous biological processes, including those essential for proper brain function. Magnesium helps regulate the brain’s stress response system, which is often dysregulated in depression. Magnesium is involved in the synthesis of serotonin, a neurotransmitter often referred to as the ‘feel-good hormone,’ which plays a significant role in mood regulation. Low levels of magnesium are commonly associated with depression. Thus, adequate magnesium levels are essential for maintaining a balanced mood and preventing the onset of depressive symptoms. Some studies have shown that magnesium supplementation can have a beneficial effect on people suffering from depression, highlighting its potential use in addition to pharmaceutical treatment methods. [PMC7352515]

Antidepressant Effects of B Complex Vitamins

B vitamins, particularly B6 (pyridoxine), B12 (cobalamin), and folate (B9), play a crucial role in maintaining mood and overall mental health. These vitamins are integral to the function of the brain and nervous system, primarily in the synthesis and regulation of neurotransmitters, such as serotonin, dopamine, and norepinephrine, which are directly linked to mood. A deficiency in these vitamins can lead to reduced neurotransmitter levels, potentially resulting in mood disturbances and depressive symptoms. [PMID: 34233510] Vitamin B6 is essential for converting tryptophan into serotonin, while B12 and folate are critical for brain function and the maintenance of nerve health.

Additionally, B12 and folate are involved in the process of methylation, a biochemical reaction essential for the production and function of neurotransmitters and the maintenance of myelin, the protective sheath around nerves.

Low levels of these B vitamins are often found in individuals with depression, and their supplementation has been associated with improved mood and the efficacy of antidepressant treatments. Moreover, these vitamins help manage and reduce elevated levels of homocysteine, an amino acid linked to brain degeneration and an increased risk of mood disorders. So it follows that adequate intake of B6, B12, and folate, either through diet or supplementation, can be an important aspect of managing mood and combating depression.

Antidepressants Deplete NAD

A deficiency of Vitamin B3, Niacin, is known to cause depression. Researchers urge that anyone with a poor diet should consider taking supplemental B vitamins, specifically B3. [PMID: 25596911]


The study titled, “Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial” reported on the results of 554 patients managed with L-methylfolate either alone or in addition to their antidepressant medications. Subjects reported significant improvements in depression symptoms and functioning. [PMC3869616]

Antidepressant Effects of L-Theanine

L-Theanine, an amino acid found predominantly in tea leaves, is known for its unique ability to promote relaxation without causing drowsiness, making it beneficial for mood regulation and stress management. It works by influencing the levels of certain neurotransmitters in the brain, including serotonin and dopamine, which play key roles in mood balance. L-Theanine is also thought to enhance alpha brain wave activity, which is associated with a state of calm alertness. This can lead to a reduction in stress and anxiety, factors often linked with depression.

Along with that, L-Theanine may help counteract the jitteriness and restlessness that can come with caffeine consumption, common in those who drink coffee or tea. Its role in improving focus and mental clarity can also indirectly contribute to better mood and cognitive function. Many people report a sense of tranquil focus and a decrease in anxious thoughts when supplementing with L-Theanine, making it a popular choice for those seeking natural ways to manage stress and improve emotional well-being. However, while L-Theanine is generally considered safe and effective, it’s important to consult with a healthcare provider before starting any new supplement, especially for individuals with existing health conditions or who are taking other medications. [PMC6836118]

Read more in our article: L-Theanine: Relaxation, Mental Clarity, and Better Sleep

Antidepressant Effects of Rhodiola Rosea

Rhodiola Rosea, a herb native to cold, mountainous regions, is often used as an adaptogen, a natural substance that helps the body adapt to stress in a healthy way. Its mood-enhancing benefits are attributed to its ability to influence key neurotransmitters in the brain, including serotonin and dopamine, which are integral to mood regulation. [PMC9228580] Rhodiola works by inhibiting the breakdown of these neurotransmitters and by affecting the body’s stress-response system. This action can lead to an improvement in mood and a reduction in stress-related fatigue, which is particularly beneficial for those experiencing mild to moderate depression or stress-induced mood swings.

Also, Rhodiola has been shown to improve cognitive function and mental performance, particularly under conditions of stress and fatigue. This can contribute to a more balanced mood and overall sense of well-being. Many people find that supplementing with Rhodiola Rosea helps them feel more energetic, less anxious, and more emotionally stable. However, it’s important to use this supplement under the guidance of a healthcare provider, as it may interact with other medications and is not suitable for everyone, particularly those with certain health conditions or those on antidepressant medications.

Read more in our article: Rhodiola: Nature’s Herbal Solution to Stress and Fatigue

Antidepressant Effects of Ashwagandha

Ashwagandha, an adaptogenic herb extensively used in Ayurvedic medicine, is known for its potential to enhance mood and mitigate stress. Its efficacy in mood regulation is primarily attributed to its ability to modulate the body’s stress response by regulating cortisol levels, the stress hormone. High cortisol levels are often associated with chronic stress, anxiety, and mood imbalances. By normalizing these levels, ashwagandha can help reduce the symptoms of stress and anxiety, contributing to a more balanced emotional state. Furthermore, this herb is believed to support neuroprotective activities, safeguarding the brain against oxidative stress, which can negatively impact mental health. It may also influence the production and modulation of key neurotransmitters, like GABA and serotonin, which play significant roles in mood and anxiety regulation. Many people who use ashwagandha report a reduction in anxiety and an improved sense of well-being. However, while ashwagandha is generally considered safe, it’s important to approach its use cautiously, especially for those on medication or with pre-existing health conditions. Consulting with a healthcare provider ensures proper dosage and safety, particularly when used in conjunction with other treatments for mood disorders. [PMC8762185]

Read more in our article: Ashwagandha Unveiled: Your Guide to Stress Relief and Better Sleep

Antidepressant Effects of Curcumin

Turmeric, particularly its active compound curcumin, is increasingly recognized for its potential benefits in mood regulation and depression management. The anti-inflammatory and antioxidant properties of curcumin are central to its mood-enhancing effects. Chronic inflammation is often observed in individuals with depression, and by mitigating this inflammation, curcumin can help alleviate depressive symptoms. Additionally, curcumin has been shown to boost brain-derived neurotrophic factor (BDNF), a protein that plays a vital role in the growth and maintenance of nerve cells, which are essential for learning, memory, and mood regulation. Low levels of BDNF are linked with depression, and by increasing BDNF levels, curcumin can potentially reverse some of these effects.

Curcumin also influences neurotransmitter levels, including serotonin and dopamine, further contributing to its antidepressant effects. Research suggests that when used as a supplement, particularly in its more bioavailable forms (as curcumin is not easily absorbed by the body), it can have a significant impact on mood enhancement and relief from depressive symptoms. Of course, while turmeric/curcumin supplements can be a beneficial add-on to treatment for depression, they should not replace conventional treatment methods. [PMID: 25046624]

Read more in our article: Curcumin: Anti-Aging Supplement for Healthier Joints, Brain, and Heart.

Antidepressant Effects of Ginko Biloba

Ginkgo Biloba, a herb derived from one of the oldest tree species, is known for its potential in enhancing cognitive function and mood. [PMC6181482] Its mood-related benefits are primarily attributed to its ability to improve blood circulation, particularly to the brain. Better blood flow ensures more efficient delivery of oxygen and nutrients, which can positively affect brain function and mood. Ginkgo Biloba also exhibits antioxidant properties, protecting the brain from oxidative stress and damage, factors often linked to cognitive decline and mood disorders. Additionally, it impacts the neurotransmitter systems, including those involving serotonin and dopamine, which are crucial for mood regulation. By modulating these neurotransmitters, Ginkgo Biloba may help alleviate symptoms of anxiety and depression, contributing to an overall improvement in emotional well-being. Some studies suggest that it can enhance memory and attention, which, when impaired, can negatively impact mood. However, it’s essential to approach the use of Ginkgo Biloba with caution, especially for individuals on medication or those with certain health conditions, as it can interact with medications and has blood-thinning properties. Consulting with a healthcare provider is crucial to determine its suitability and ensure safe and effective usage as part of a broader approach to managing mood and cognitive health.

Read more in our article titled: Ginko Biloba: The Real Story From Better Memory to Lower Stress


A review entitled “Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis” found that, “saffron was as effective as synthetic antidepressants.” Dose: 30mg extract OR dried 100mg | QD | 6-12 weeks [PMID: 32221179]

Anti-Suicide Effects of Low-Dose Lithium

In some geographical regions, the concentration of lithium in drinking water is high, and there is little concern about being deficient in this trace mineral. However, when the natural occurrence of lithium in water and soil is very low, it may lead to a corresponding deficiency in local water and food sources.

The use of certain water filters can also reduce lithium. This scarcity can result in a very low dietary intake of lithium for people living in these areas and this may be more of a problem than previously recognized. Research suggests lithium may be necessary in trace amounts to prevent neurological problems leading to irritability, mood disorders, and even contributing to suicide. Some are proposing that adding low levels of lithium to drinking water in low-lithium areas should be considered as a public health measure. [PMC8891154]


Studies have found that carnitine supplementation, especially acetyl-L-carnitine, can improve the symptoms of depression. An article in Frontiers in Nutrition says acetyl-L-carnitine “is expected to become a new treatment for depression. Other clinical studies indicated that the level of acetyl-L-carnitine in patients with major depressive disorder was significantly lower than healthy controls. It suggests that carnitine might be involved in the pathological process of depression”. [PMC8964433]


Tryptophan is an amino acid we need to get from our diet. When there is a deficiency of tryptophan, serotonin deficiency will result because tryptophan is converted to 5-HTP, and then to serotonin in the brain. Studies have found that consuming more dietary tryptophan can lead to less depressive symptoms. [PMC4393508]


Guidelines from the Canadian Network for Mood and Anxiety recommended DHEA as a third-line treatment for depression. Low levels of the hormone, DHEA are associated with depression, but the best practice is to measure blood levels of the hormone to find out whether your DHEA is low. Side effects of DHEA include facial hair and PCOS in women, acne, and hypertension. [PMC4994794]

Serotonin-Raising Nutritional Supplements

Saint John’s Wort, SAMe, and 5-HTP all have the effect of raising serotonin levels, which is thought to be why they are effective for depression. Their serotonin-raising ability is also the reason you want to be cautious when using them. Don’t combine these together or with serotonin-raising prescription antidepressants without discussing it with your physician or pharmacist.

Antidepressant Effects of St. John’s Wort

St. John’s Wort is a widely popular herbal remedy known for its mood-lifting effects. It is believed to operate on serotonin, dopamine, and norepinephrine, the chemicals in the brain which regulate mood. These neurotransmitters are of utmost importance for emotional feelings. It is thought that St. John’s Wort stops the recycling of these chemicals in the brain, thus releasing more of it and helping to improve mood and relieve depression symptoms. In addition, researchers argue that some compounds contained in St. John’s Wort, specifically hyperforin and hypericin, also contribute to its antidepressant efficacy.

In addition, researchers argue that, some compounds contained in St. John’s Wort, specifically hyperforin and hypericin, also contributes to its antidepressant efficacy. It is usually used in cases of mild to moderate depression. In one review, researchers concluded, “SJW has shown to be comparable, if not more efficacious, than most standard treatment options for depression.” [PMC9587902]

Caution: St. John’s Wort interacts with many medications. It should not be added to SSRI without consulting with your physician because a serious interaction may result. [*] Read more in our article: St. John’s Wort: The Natural Remedy For Mood Support.

Antidepressant Effects of SAMe

S-Adenosylmethionine, commonly referred to as SAMe, is a naturally occurring compound in the body and its antidepressant effects have been studied. SAMe is used in the synthesis and metabolism of neurotransmitters like serotonin, dopamine and norepinephrine, which all impact mood regulation. SAMe can help in the production and breakdown of these neurotransmitters and enhance mood and reduce depression. [PMC7487540]

SAMe also contributes to the maintenance of cell membranes as well as the immune system, both of which play a role in brain general health. SAMe, when taken as a supplement, is known to cause an improvement in mood in some individuals, notably those with depression that results from low serotonin levels. Caution: SAMe can interact with other drugs and the potential for serotonin syndrome [*]when combining excessive SAMe with antidepressants can be very serious.

Read more in our article: Decoding the Benefits of SAMe: Your Guide to Smart Supplementation.

Antidepressant Effects of 5-HTP

5-HTP is a naturally occurring amino acid that functions as a precursor to the neurotransmitter serotonin which is critical in the regulation of mood.

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid and a precursor for serotonin. Serotonin is one of the neurotransmitters involved in the regulation of mood. In the brain, 5-HTP is converted into serotonin, which has a positive impact on mood, emotions, and sleep. Supplementation with 5-HTP can increase the production of serotonin, and thereby improve symptoms of depression, anxiety, and sleep disorders. [PMC5728156] This is more important since low serotonin levels are usually associated with mood disorders. 

Furthermore, it is believed that 5-HTP has a shorter duration of action than some of the conventional antidepressants which take several weeks to have any effect. However, while 5-HTP is available over the counter and might seem like a straightforward solution, it should be used cautiously. Caution: a serious interaction with SSRI antidepressants can occur, known as Serotonin Syndrome. [*] This accumulation of serotonin may prove to be life-threatening. For those on other medications for mental health, it’s important to consult a health expert before starting 5-HTP.

Read more in our article: Exploring the Benefits of 5-HTP: Elevate Your Mood Naturally.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Supplements For Managing Mood

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Supplement Safety Information

When using supplements like Omega-3 Fatty Acids, St. John’s Wort, SAMe, 5-HTP, Vitamin D, Magnesium, Probiotics, Zinc, B Vitamins (B6 and B12), Folate, L-Theanine, Rhodiola Rosea, Ashwagandha, Turmeric/Curcumin, and Ginkgo Biloba for mood enhancement, their safety is a key consideration. Most are derived from natural sources and are well-tolerated when used correctly. Omega-3s, Vitamin D, Magnesium, and B vitamins, vital for brain health, generally have a good safety profile within recommended doses. Similarly, probiotics and traditional herbs like Ashwagandha and Turmeric/Curcumin are safe for many users. Caution is advised with St. John’s Wort, SAMe, and 5-HTP due to potential interactions with SSRI medication that could lead to serotonin syndrome, which can be quite serious. Consulting a healthcare provider before starting any supplement, especially for those on medication or with health conditions, ensures safe and effective use. With the right guidance, these supplements can be a safe part of managing mood.

Medication Interactions:

Medication CategorySupplementExpected Interaction
Antidepressants (SSRIs, SNRIs, Tricyclics)St. John’s WortRisk of serotonin syndrome
S-Adenosylmethionine (SAMe)Risk of serotonin syndrome
5-HTP (5-Hydroxytryptophan)Risk of serotonin syndrome
Ginkgo BilobaCan lead to serotonin syndrome
Blood Thinners (like Warfarin)Omega-3 Fatty AcidsMay increase bleeding risk
St. John’s WortCan decrease their efficacy
Turmeric/CurcuminMay increase bleeding risk
Ginkgo BilobaIncreased bleeding risk
Antihypertensive MedicationsOmega-3 Fatty AcidsCan enhance the effect, leading to low blood pressure
MagnesiumMay enhance hypotensive effects
Rhodiola RoseaCan enhance hypotensive effects
L-TheanineCan enhance the effects of these drugs
Birth Control PillsSt. John’s WortMay reduce effectiveness
Certain Chemotherapy DrugsSt. John’s WortMay reduce effectiveness
B Vitamins (especially B6)B6 may affect the efficacy
Cyclosporine (Organ Transplant Patients)St. John’s WortDecreased effectiveness
Antiretrovirals (HIV Treatment)St. John’s WortMay reduce effectiveness
SteroidsVitamin DCan reduce calcium absorption, affecting efficacy
AntibioticsMagnesiumCan affect absorption
ZincCan interfere with absorption
ProbioticsBeneficial for reducing side effects, timing important
Osteoporosis Medications (Bisphosphonates)MagnesiumCan interfere with absorption
Cough Medicines (Dextromethorphan)5-HTP (5-Hydroxytryptophan)Risk of serotonin syndrome
DiureticsZincIncreased risk of zinc depletion
Antiepileptic DrugsB Vitamins (especially B6)B6 may interfere with effectiveness
FolateCan interfere with effectiveness
Ginkgo BilobaMay decrease seizure threshold
Methotrexate (Cancer, Autoimmune Diseases)FolateCan impact efficacy
Thyroid MedicationsAshwagandhaMay increase hormone levels
SedativesAshwagandhaCan enhance effects
Diabetes MedicationsTurmeric/CurcuminCan enhance effects, leading to hypoglycemia
StimulantsL-TheanineMay reduce stimulatory effects

Supplement Interactions:

SupplementInteracting SupplementPotential Interaction
Omega-3 Fatty Acids
St. John’s WortSAMe, 5-HTPRisk of serotonin syndrome
S-Adenosylmethionine (SAMe)St. John’s Wort, 5-HTPRisk of serotonin syndrome
5-HTP (5-Hydroxytryptophan)St. John’s Wort, SAMeRisk of serotonin syndrome
Vitamin DMagnesiumEnhanced absorption and utilization
MagnesiumVitamin DEnhanced absorption and utilization
B Vitamins (B6 and B12)
L-TheanineCaffeineCan reduce the stimulatory effects of caffeine
Rhodiola Rosea
Ginkgo Biloba

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

What Lab Tests Might Be Helpful In Managing Mood?

Several lab tests can be helpful in managing mood, particularly when diagnosing or treating mood disorders like depression or anxiety. These tests can provide insight into underlying physiological factors that may affect mood. Here are some common ones:

  • Complete Blood Count (CBC): This test checks for anemia, infection, and many other diseases. Anemia, for instance, can lead to symptoms like fatigue and depression.
  • Thyroid Function Tests: Thyroid hormones, tested through TSH, Free T3, and Free T4 tests, play a significant role in regulating mood. Both hyperthyroidism and hypothyroidism can cause mood disturbances.
  • Vitamin D Levels: Low levels of Vitamin D are associated with various mood disorders, including depression.
  • Vitamin B12 and Folate Levels: Deficiencies in these vitamins can affect mood, leading to symptoms like fatigue and depression.
  • Iron Studies: Iron deficiency, which can lead to anemia, is often linked with low mood and energy levels.
  • Electrolyte Panel: An imbalance in electrolytes, such as sodium, potassium, and calcium, can affect mental health and mood.
  • Liver Function Tests: Liver problems can affect mood and cognitive function due to the buildup of toxins in the body that the liver can’t properly process.
  • Kidney Function Tests: Similar to liver function, kidney issues can lead to mood changes and cognitive issues.
  • Blood Sugar Levels (Glucose Tests): Blood sugar imbalances can affect mood and energy levels, particularly in people with diabetes.
  • Lipid Profile: This can help assess cardiovascular health. There is a growing understanding of the link between heart health and mental health.
  • Hormonal Tests: For women, checking estrogen and progesterone levels can be useful, as hormonal imbalances can influence mood.
  • Inflammatory Markers: Tests like C-reactive protein (CRP) can identify levels of inflammation in the body, which has been linked to depression.
  • Adrenal Function Tests: These can include cortisol levels, which may be altered in individuals with chronic stress or conditions like adrenal fatigue.
  • Amino Acid Profiles: Amino acids are precursors to neurotransmitters. Imbalances can affect mood and cognitive function.
  • Urinalysis: Can provide general information about overall health and the presence of substances that might affect mood.

To Sum It Up

The diverse range of supplements like Omega-3 Fatty Acids, St. John’s Wort, SAMe, 5-HTP, Vitamin D, Magnesium, Probiotics, Zinc, B Vitamins (especially B6 and B12), Folate, L-Theanine, Rhodiola, Ashwagandha, Curcumin, and Ginkgo Biloba offer promising benefits for mood enhancement and overall mental well-being.

Healthy, whole food choices, physical activity, and stress reduction form the foundation for healing depression. These supplements, each with their unique properties, can also contribute to managing mood disorders, reducing stress, and promoting a healthy, balanced state of mind.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

About the Author

Supplement Sciences

If you have any thoughts on this article, feel free to share them with us by emailing them to

Leave a Reply