CoQ10: Supplement Mitochondrial Energy Production For Your Heart, Brain, And More

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Along with providing information on whether Coenzyme Q10 supplements might be right for you, this article also links to Fullscript where you can buy CoQ supplements online through the secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

CoQ10 is found in every cell of the human body. It’s essential for the health of virtually all human tissues and organs. This article covers the science-backed benefits of CoQ10 supplements, exploring how they can support overall health, enhance energy levels, and potentially offer protection against certain health conditions.

Whether you’re looking to boost your energy, improve heart health, or simply understand more about this vital compound, our exploration of CoQ10 offers valuable insights.

What is CoQ10?

CoQ10, short for Coenzyme Q10, is a natural substance found in our bodies. It is present in every cell and plays a big role in producing energy. CoQ10 helps the cells’ powerhouses, called mitochondria, turn the food we eat into energy that our bodies can use.

Besides helping make energy, CoQ10 is also a powerful antioxidant. Antioxidants are substances that protect our cells from damage caused by harmful particles called free radicals. Free radicals can come from things like pollution, smoking, or even normal body processes. By fighting free radicals, CoQ10 helps keep our cells healthy.

Our bodies naturally produce CoQ10, but sometimes we might not have enough of it. This can happen as we get older or due to certain health conditions. To help increase CoQ10 levels, some people take CoQ10 supplements. These supplements are available in different forms, like capsules and tablets.

CoQ10 supplements may have several health benefits. They can help improve heart health, support brain function, and boost energy levels. However, it’s important to talk to a healthcare professional before taking any supplements, including CoQ10, to make sure they are safe and right for you.

Ubiquinone Vs Ubiquinol: Some Myths About Absorption

Marketers of CoQ10 supplements have misread the bioavailability research.

CoQ10 exists within the body as ubiquinone and ubiquinol which are continually inter-converted within cells as part of the normal function of CoQ10. In the blood, CoQ10 is transported in ubiquinol form bound to LDL no matter what the initial dietary form was taken. Ubiquinol/one is unstable by nature. Absorption was initially thought to be better with the ubiquinol form of CQ10, so some manufacturers of reduced CoQ10 supplements have claimed that the reduced form of CoQ10 is more readily absorbed, even though more recent absorption and bio-availability studies questioned that. The most critical factor is the crystals must be dispersed from their manufactured crystalline form or they will be less absorbable by 75%. [PMC7278738]

Researchers believe that intestinal absorption of CoQ10 is highly variable among individuals regardless of the form of CoQ10 (ubiquinone/ubiquinol) administered. The body is limited in how much CoQ10 it can absorb at a given time, and thus if an individual takes several 100 mg capsules together, some of the CoQ10 tends to be wasted. [PMID:16873950] There is also some evidence that liposomal forms of CoQ10 are better absorbed. [PMID: 31475897]

What are the Benefits of CoQ10?

  • Boosts Energy: CoQ10 plays a pivotal role in the mitochondrial electron transport chain, a crucial process in cellular energy production. By facilitating the conversion of oxygen and nutrients into ATP (adenosine triphosphate), the primary energy currency of cells, CoQ10 helps sustain higher energy levels. This function is especially important in high-energy demanding organs like the heart, liver, and kidneys.
    • Fatigue Reduction: Researchers reviewing clinical trials concluded, “that CoQ10 is an effective and safe supplement for reducing fatigue symptoms.” [PMC9449413]
  • Supports Heart Health: CoQ10 is vital for heart health due to its role in maintaining the energy production in heart muscle cells. It has shown potential in improving heart function, possibly reducing the symptoms of heart failure. Additionally, its antioxidant properties may help prevent the oxidation of LDL cholesterol, a key risk factor for heart disease.
    • Improves Endothelial Function: Researchers found that, “CoQ10 add-on metformin therapy improves endothelial dysfunction and inflammatory changes in patients with T2DM”. [PMC6943859]
  • Enhances Exercise Performance: By improving mitochondrial function and energy production, CoQ10 can enhance physical performance. Studies suggest that supplementation can help reduce fatigue during exercise and improve muscle recovery. This can be particularly beneficial for endurance athletes or those engaged in intense physical activity.
  • Protects Cells from Damage: As a powerful antioxidant, CoQ10 helps neutralize harmful free radicals, which are unstable molecules that can cause oxidative stress and cellular damage. This protection is crucial for maintaining cell integrity and function, potentially reducing the risk of chronic diseases.
  • Supports Brain Health: The brain is highly susceptible to oxidative stress due to its high fatty acid content and oxygen demand. CoQ10’s antioxidant properties may protect brain cells from oxidative damage and reduce the action of harmful compounds that can lead to brain diseases. Some research suggests it might also help in reducing the occurrence of migraines.
  • Improves Skin Health: On the skin, CoQ10 can help combat signs of aging. It protects the skin from oxidative damage, which can lead to wrinkles and fine lines. Some studies indicate that topical application of CoQ10 improves skin texture and may protect against photoaging – damage caused by long-term exposure to the sun.
  • May Help with Diabetes: CoQ10 might have a beneficial role in managing diabetes. Some research suggests it can help improve insulin sensitivity and control blood sugar levels. By mitigating oxidative stress, which plays a role in the development of insulin resistance, CoQ10 supplementation could be a supportive therapy in diabetes management.
  • Chronic Fatigue Syndrome (CFS) & Post Covid Fatigue: A study of 207 people with CFS showed that 200 mg of CoQ10 along with NADH (a form of Vitamin B3) improved energy and sleep. [PMCID: PMC8399248]

Each of these benefits underscores CoQ10’s importance in overall health. Its role in energy production, coupled with its antioxidant properties, makes it a key nutrient in supporting various bodily functions and protecting against a range of health issues.

Food Sources of CoQ10

There are very small amounts of CoQ 10 in organ meats, generally less than 10 mg per 3 oz portion.

What is MitoQ?

MitoQ is a specialized form of Coenzyme Q10 (CoQ10) with a unique chemical structure that allows it to precisely target and accumulate within the mitochondria, the energy-producing powerhouses within our cells. Its structure enables it to bypass cellular barriers, making it highly effective at neutralizing harmful reactive oxygen species (ROS) within the mitochondria and shielding them from oxidative damage. This targeted approach sets MitoQ apart, potentially offering superior benefits for mitochondrial health and cellular function.

How Does It Concentrate In The Mitochondria?

MitoQ’s ability to specifically target and accumulate within mitochondria is attributed to its unique chemical structure, which combines a lipophilic (fat-attracting) component with a positively charged component. This combination allows MitoQ to overcome the typical barriers that hinder the entry of other molecules into mitochondria.

The chemical structure of MitoQ involves attaching a lipophilic tail to Coenzyme Q10 (CoQ10). This lipophilic tail makes MitoQ attracted to the lipid (fat) components of cell membranes, including the mitochondrial membrane. Additionally, MitoQ carries a positive charge due to the addition of a quinone group. This positive charge helps MitoQ to be selectively taken up by the negatively charged mitochondrial membrane. This precise targeting allows MitoQ to exert its antioxidant and protective effects directly at the site of mitochondrial function, helping to safeguard these vital organelles from oxidative damage and support overall cellular health.

How Does The Dose of MitoQ Compare To the CoQ10 Dose?

Generally, MitoQ is considered to be more potent and effective at lower doses compared to traditional CoQ10 due to its targeted delivery to the mitochondria. Typically, MitoQ supplements are taken in lower doses than traditional CoQ10. A common guideline is that 10 mg of MitoQ is roughly equivalent to 100 mg of CoQ10 in terms of antioxidant and mitochondrial support. However, it’s important to note that these equivalency estimates can be quite approximate and may vary based on individual responses.

Are CoQ10 Supplements Safe?

Coenzyme Q10 (CoQ10) is widely recognized for its safety profile and is generally well-tolerated by most individuals when taken as a dietary supplement. Numerous studies have demonstrated its safety, even at relatively high doses and during long-term use. Side effects are rare and typically mild, often related to gastrointestinal discomfort, and can be mitigated by taking the supplement with food. CoQ10 does not significantly interact with most medications, although it’s always prudent to consult with a healthcare provider before starting any new supplement, especially for individuals on medication or with existing health conditions.

Medications That Interact With CQ10

  • Blood thinners (like Warfarin): CoQ10 might make blood thinners less effective, which could increase the risk of blood clots.
  • Chemotherapy drugs: CoQ10 may interact with some chemotherapy drugs, possibly affecting their effectiveness. Consult your healthcare professional if you’re undergoing chemotherapy and thinking about taking CoQ10 supplements.
  • Blood pressure medications: CoQ10 could lower blood pressure, so taking it with blood pressure medications might cause your blood pressure to drop too much.
  • Thyroid medications: CoQ10 might affect thyroid hormone levels, so taking it with thyroid medications could change how well these medications work.

This list might not include all possible interactions, and the severity of interactions can vary depending on individual factors like age, health status, and dosage. Make sure to consult your healthcare professional before starting or stopping any medications or supplements, including CoQ10.

Supplement Interactions with CoQ10

  • Omega-3 fatty acids: Both CoQ10 and omega-3s have been shown to help support heart health. Taking them together might have added benefits for heart health, but it’s important to talk to your healthcare professional before combining these supplements.
  • Vitamin E: CoQ10 and vitamin E are both antioxidants that can help protect our cells from damage. Taking them together might boost their antioxidant effects. This can cause an imbalance of antioxidant levels.
  • L-carnitine: L-carnitine is a supplement that helps our bodies turn fat into energy. Combining CoQ10 with L-carnitine might improve energy levels and support heart health, but you should consult your healthcare professional before taking these supplements together.
  • Magnesium: Magnesium is involved in many processes in our bodies, including energy production. Taking magnesium with CoQ10 might help improve energy levels, but it’s essential to talk to your healthcare professional before combining these supplements.

These are just a few examples of nutritional supplements that could interact with CoQ10. The effects of these interactions can vary depending on individual factors, so it’s always a good idea to consult a healthcare professional before taking any new supplements or combining them with CoQ10.

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CoQ10 -100 mg (Protocol For Life)

  • Cardiovascular Support*
  • Promotes Cellular Energy Production*

Coenzyme Q10 (CoQ10) is a vitamin-like compound present in almost all cells, where it is necessary for cellular energy production.* CoQ10 concentrations are highest in the heart, where chemical energy availability is critical. CoQ10 also functions as a powerful fat-soluble free radical scavenger within cell membranes and vascular structures.*

Suggested Use:
Take 1 softgel 1 to 2 times daily with food, or as directed by your healthcare practitioner.

Amount Per 1 Softgel Serving
Vitamin E … 30IU
(from Mixed Tocopherols)(soy-free)
Coenzyme Q10 … 100mg
(CoQ10)


CoQ10– 200 mg (Jarrow)

Cholesterol Antioxidant*Promotes Cellular Energy Production*

  • Original CoQ10 Capsules
  • Physician Supported Cardiovascular Protection*
  • Enhances levels depleted by statin use*
  • Natural Trans Configuration Only
  • Pharmaceutical Grade Kaneka Q10®

Co-Q10, an important antioxidant found in high concentration in human heart and liver, is part of the cells’ electron transport system, needed for ATP (i.e., energy) production within the cells.* Jarrow Formulas® Co-Q10 restores Co-Q10 levels reduced by the use of statins.*

Jarrow Formulas® Co-Q10 is derived from fermentation and consists only of the natural trans configuration, the same as is synthesized in the human body.

Jarrow Formulas® supports clinical research on Coenzyme Q10.

Suggested Use:
Take 1 capsule up to 3 times per day with food or as directed by your qualified healthcare professional.

Serving Size: One Capsule

Amount Per Serving
Coenzyme Q10 … 200mg
(Ubiquinone)

MitoQ pure by MitoQ

MitoQ Pure is a world-first antioxidant molecule that directly combats cellular stress for boosted energy, faster recovery, and better aging every day. Great health starts in your cells.

MitoQ Pure’s only active ingredient is MitoQ. That’s on purpose. Each capsule contains 5mg of our world-first antioxidant molecule. Suggested Use: Take 2 capsules before food.

Serving Size: 2 capsules

Amount Per Serving
MitoQ® … 10mg (as mitoquinol mesylate)

[PMC7452004]


For Heart Failure: High Dose CoQ10

This 600 mg dose may be most appropriate for people with congestive heart failure.


CoQ10 600 mg (Protocol For Life)

Coenzyme Q10, also called ubiquinone, is present in almost all cells, where it is necessary for mitochondrial energy production. The body’s highest concentrations of Coenzyme Q10 (CoQ10) are found in the heart, where constant chemical energy availability is imperative. In addition to its benefits for cardiac function through energy production, CoQ10 also functions as a powerful fat soluble antioxidant, providing protection against free radical attack for vascular structures, as well as for other tissues.

 As a dietary supplement, take 1 softgel 1 to 2 times daily with meals.  For intensive use, take 180-1200 mg daily under the supervision of a health care practitioner.

Amount Per 1 Softgel Serving
Vitamin E … 30IU (as d-alpha Tocopherol)
Zinc … 4mg (from Zinc Oxide)
Coenzyme Q10 … 600mg (CoQ10)
Soy Lecithin … 50mg


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

CoQ10 supplements offer a range of health benefits, from enhancing energy production and cellular health to their potential role in reducing the risk of chronic diseases. This compound, vital in the functioning of almost all body cells, particularly shines in its ability to support heart health and combat oxidative stress. The growing body of research around CoQ10 highlights its significance in maintaining overall well-being. While it’s a naturally occurring substance in the body, supplementation can be a practical approach to replenishing CoQ10 levels, especially in those with specific health needs or age-related decline. Embracing a holistic approach to health, which includes understanding and utilizing nutrients like CoQ10, can play a key role in fostering long-term wellness.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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