Autism: The Power of Nutrients for a Mind on the Spectrum

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Good nutrition is being recognized as a major key to improving the well-being of people with autism. This article looks at how certain supplements can help improve overall health by filling in nutritional gaps and supporting brain health. This article takes a deep dive into which supplements might be most helpful for the unique needs of people with autism.

What Is Autism?

Autism, or autism spectrum disorder (ASD), is a complex developmental condition that involves persistent challenges in social interaction, speech and nonverbal communication, and restricted or repetitive behaviors. The effects of autism and the severity of symptoms vary widely among people, which is why it is referred to as a “spectrum” disorder. Symptoms typically appear in the early developmental period, often before the age of three.

Common symptoms indicating autism include difficulties with communication and interaction with other people, such as trouble with conversation, eye contact, and understanding social cues. People with autism may also show limited interest in activities or play, preferring repetitive actions or becoming intensely focused on specific topics. They might react in unusual ways to sensory inputs, like being bothered by certain sounds or textures, or seeking sensory stimulation.

The causes of autism are not fully understood, but research indicates that genetics play a key role. Various genetic mutations appear to increase the risk of autism. Environmental factors, such as advanced parental age, pregnancy and birth complications, and pregnancies spaced less than one year apart, may also contribute to the risk of autism. However, it’s important to debunk the myth that vaccines cause autism; extensive research has found no link between vaccines and autism spectrum disorder.

What Food and Lifestyle Factors Are Important For Managing Autism?


Managing autism spectrum disorder (ASD) involves a comprehensive approach that includes various food and lifestyle factors. These strategies can help support overall well-being and address specific symptoms associated with autism. It’s important to note that while these interventions may be beneficial, they should complement professional medical and behavioral therapies tailored to the individual’s needs.

Food and Nutrition

  • Nutrient-Dense Foods: A nutritious diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can support brain health and overall functioning. Essential nutrients like omega-3 fatty acids, found in fish and flaxseeds, are particularly important for neural development.
  • Avoiding Food Sensitivities: Some people with autism may have food sensitivities or allergies, particularly to gluten (found in wheat, barley, and rye) and casein (a protein in dairy). Eliminating or reducing these foods can sometimes improve behavior and gastrointestinal symptoms, but it’s important to consult with a healthcare provider before making significant dietary changes.
  • Supplementation: In some cases, dietary supplements may be recommended to address nutritional deficiencies common in autism, such as vitamins D and B12, magnesium, and omega-3 fatty acids. Professional guidance is crucial to determine the need and appropriate dosage.

Lifestyle Factors

  • Structured Routine: Many individuals with autism thrive on routine and predictability. Establishing a consistent daily schedule for meals, therapy sessions, school, and leisure activities can help reduce anxiety and improve behavior.
  • Physical Activity: Regular exercise is beneficial for reducing stress, improving mood, and enhancing physical health. Activities should be chosen based on the individual’s interests and abilities, ranging from walking or swimming to team sports or martial arts.
  • Sleep Hygiene: Ensuring adequate and quality sleep is essential for managing ASD symptoms. This can involve establishing a calming bedtime routine, maintaining a cool and quiet sleep environment, and keeping consistent sleep and wake times.
  • Sensory-friendly Environment: Many people with autism are sensitive to sensory inputs. Creating a sensory-friendly living space, such as using soft lighting, minimizing noise, and providing sensory toys or tools, can help reduce overstimulation and distress.

Social and Emotional Support

  • Positive Social Interactions: Encouraging social engagement through structured playdates, special interest clubs, or sports teams can help improve communication skills and social understanding.
  • Stress Management: Techniques such as mindfulness, deep breathing exercises, or yoga can be effective in managing stress and anxiety commonly experienced by individuals with autism.

12-month treatment study of a comprehensive nutritional and dietary intervention. Participants were 67 children and adults with autism spectrum disorder (ASD) ages 3–58 years….

treatments were added sequentially, including essential fatty acids, Epsom salt baths, carnitine, digestive enzymes, and a healthy gluten-free, casein-free, soy-free [Healthy Gluten Free, Casein Free] diet…..The treatment group had significantly greater increases in EPA, DHA, carnitine, and vitamins A, B2, B5, B6, B12, folic acid, and Coenzyme Q10.

The positive results of this study suggest that a comprehensive nutritional and dietary intervention is effective at improving nutritional status, non-verbal IQ, autism symptoms, and other symptoms in most individuals with ASD. Parents reported that the vitamin/mineral supplements, essential fatty acids, and HGCSF diet were the most beneficial.

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial [PMC5872787]

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. This article aims to offer valuable insights into which nutritional supplements have undergone scientific study and shown promise in supporting specific health conditions. We break down the research, so you can work with your medical providers to make informed decisions about adding supplements to your health regimen. For personalized advice tailored to your needs, we recommend consulting with a registered dietitian in addition to your primary care provider.

Check with your physician when adding supplements. While supplements are generally safe for most people, do not add nutritional supplements without your physician’s specific approval if you are pregnant or nursing, are undergoing cancer treatment, have a history of organ transplant, liver or kidney disease, or take medications that interact with supplements.


Nutritional supplements can play a role in managing autism spectrum disorder (ASD), particularly when addressing specific nutritional deficiencies or symptoms. Below are some supplements commonly considered for individuals with autism, based on research and clinical practice in either children or adults with autism.

  • Multivitamins: A comprehensive multivitamin/mineral supplement can help address nutritional gaps. Particular attention is often given to vitamins B6 and B12, magnesium, and zinc, as deficiencies in these nutrients have been linked to symptoms of autism in some cases. [PMC9318435]
    • Folate: High-dose folinic acid, a form of folate, has been researched for its potential to improve verbal communication in children with autism, especially those with folate receptor autoantibodies. PMC5794882
    • Methyl-B12: Methyl-B12, particularly in its methylcobalamin form, has been explored in studies as a treatment for autism spectrum disorder (ASD). Research B12 can improve communication, daily skills, behavior, and other symptoms like sleep problems and gastrointestinal issues, as well as biochemical markers, showing promise as a treatment option. PMC8400809
    • Zinc: Zinc supplements could be beneficial for children with ASD, especially because they often have low levels of zinc. These supplements can help improve symptoms like diarrhea, boost the immune system, and reduce neurosensory issues linked to zinc deficiency. PMC4386645
    • Selenium: An essential trace mineral with antioxidant properties, selenium is sometimes supplemented to support overall health and detoxification pathways in individuals with autism. PMC3966422
    • Vitamin E: An antioxidant that protects cells from damage, Vitamin E supplementation is sometimes considered for its potential neuroprotective effects in autism. PMID: 24631384
    • Vitamin D: Low levels of vitamin D have been observed in some people with autism. Supplementation may support bone health, immune function, and may improve autism symptoms. Vitamin D dosages should be adjusted based on your blood level with many clinicians recommending an optimal Vitamin D level of 50-80 ng/ml. Vitamin D Labs (affiliate link) can be ordered in the NutriScape Lab Shop.
  • Omega-3 Fatty Acids: Essential fatty acids, especially omega-3s found in fish oil, have been shown to support brain function and may improve aspects of behavior, social interaction, and learning in some individuals with autism. PMC10227477
  • Magnesium: Often paired with vitamin B6, magnesium supplementation may help reduce irritability and improve sleep patterns in individuals with autism. PMID: 16846101
  • Taurine: An amino acid that supports neurological development and regulates water and mineral levels in the blood, taurine supplementation is explored for its potential benefits in managing autism symptoms. PMC10497788
  • Probiotics: Given the gut-brain axis’s role in autism, probiotics may help improve gastrointestinal symptoms and modify behavior by influencing gut health. [PMC10060862]
  • Fiber: Adding fiber to the diet can benefit adults with autism by improving gut health. Since a healthy microbiome can improve brain health, fiber may play a role in managing symptoms associated with autism. [PMC9355470]
  • Melatonin: For individuals with autism experiencing sleep disturbances, melatonin supplementation can help regulate sleep cycles and improve sleep quality. [PMID: 24050742]

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Supplement Safety Information

While nutritional supplements are often explored as complementary options for managing autism spectrum disorder (ASD), ensuring their safety is paramount. It’s essential to remember that even though supplements can offer potential benefits, they are not without risks. The safety and efficacy of supplements can vary greatly, and interactions with prescribed medications or other supplements can occur. Therefore, before incorporating any supplement into the regimen of someone with autism, consultation with healthcare professionals is crucial. A healthcare provider can offer guidance based on the latest research, help identify any potential risks, and ensure that the supplement regimen is tailored to the individual’s specific health needs and conditions. This careful, individualized approach ensures that supplements are used safely and effectively as part of a broader strategy for managing ASD.

Medication Interactions:

When considering nutritional supplements for managing Autism Spectrum Disorder (ASD), it’s important to be aware of potential interactions with commonly prescribed medications. Below is a list of some medications used in ASD management and the supplements that might interact with them. Please note, this list is not exhaustive, and the nature of interactions can vary based on individual health factors, dosage levels, and specific formulations of both supplements and medications. Always consult with healthcare professionals before starting any new supplement or medication.

  • SSRIs (Selective Serotonin Reuptake Inhibitors)
    • Omega-3 Fatty Acids: May enhance the antidepressant effect of SSRIs.
    • 5-HTP (5-Hydroxytryptophan): Increases risk of serotonin syndrome when taken with SSRIs.
  • Antipsychotics
    • Melatonin: This may enhance the sedative effect of antipsychotics.
    • N-Acetylcysteine (NAC): Can possibly interact with antipsychotic medications, affecting their efficacy.
  • Stimulants (Used for ADHD symptoms in ASD)
    • Magnesium: May reduce the absorption or efficacy of stimulant medications.
    • Vitamin C: Can increase the acidity of urine, might reduce the effectiveness of stimulant medications by increasing their excretion.
  • Anticonvulsants (Used for seizure control)
    • Calcium: Anticonvulsants can decrease calcium absorption; supplementation may be needed, but timing is crucial to avoid interaction.
    • Folate: Some anticonvulsants can interfere with folate metabolism; supplementation might be required, but consult healthcare provider due to potential for interaction.
  • Mood Stabilizers
    • Omega-3 Fatty Acids: Possible interaction affecting blood clotting, especially with medications that also affect clotting.
    • L-Theanine: May enhance or interfere with the action of mood stabilizers, affecting their efficacy.
  • Antibiotics
    • Probiotics: While generally recommended to support gut health, especially after antibiotic use, timing of administration should be spaced to avoid reducing antibiotic efficacy.
    • Calcium: Can bind to certain antibiotics in the gut, reducing their absorption and effectiveness.

Supplement Interactions:

When considering supplement use for Autism Spectrum Disorder (ASD), it’s important to be aware of how these supplements might interact with each other. Here’s a list of potential interactions between supplements commonly considered for ASD:

  • Omega-3 Fatty Acids and Vitamin E: Vitamin E can increase the anti-inflammatory effects of Omega-3 fatty acids but taking them in very high doses together may increase the risk of bleeding.
  • Magnesium and Calcium: These two minerals can compete for absorption in the body. High doses of one can affect the absorption and effectiveness of the other.
  • Zinc and Copper: High doses of zinc can decrease copper absorption and might lead to a copper deficiency.
  • Folate and Vitamin B12: These supplements work closely together in the body. An imbalance by taking high doses of one without the other can mask or exacerbate deficiencies, particularly a vitamin B12 deficiency.
  • Vitamin D and Calcium: Vitamin D enhances calcium absorption in the body, which can be beneficial but also warrants monitoring to avoid hypercalcemia, especially if calcium supplements are also being taken.
  • Iron and Calcium: Calcium can interfere with the absorption of iron. It’s generally advised to separate the intake of these two supplements to maximize their absorption.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Nutritional supplements can enhance the management of Autism Spectrum Disorder (ASD) by supporting brain function and reducing symptoms. Their effectiveness varies, so integrating them with conventional treatments and consulting healthcare professionals, especially Registered Dietitians specialized in autism, is crucial. This approach ensures personalized, safe, and effective supplementation. For better outcomes, seek expert guidance to optimize overall well-being.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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