Anticonvulsants: Critical Drug-Nutrient Interactions

Anticonvulsant include medications like Dilantin®, Lyrica®, Mysoline®, Tegertol®, Trileptal®, or others.

Folic acid, Ginko Biloba, Niacin (B3), and St. John’s wort may interfere with the effectiveness of antiepileptic drugs. DO NOT TAKE GINKO BILOBA, ST. JOHN’S WORT, OR HIGH DOSE FOLIC ACID OR NIACIN SUPPLEMENTS WITHOUT YOUR PHYSICIAN’S APPROVAL.

Vitamin D: Dilantin, Phenobarbital, and Tegretol can increase the breakdown of vitamin D, leading to a decrease in calcium absorption. People taking these medications for 6 months or more should consider calcium and vitamin D supplements. [PMID: 17445763] Vitamin D dosages should be adjusted based on your blood level with many clinicians recommending an optimal Vitamin D level of 50-80 ng/ml. Vitamin D Labs (affiliate link) can be ordered in the NutriScape Lab Shop.

Vitamin B12: Dilantin, Phenobarbital, and Mysoline have been reported to reduce vitamin B12 absorption as well as vitamin B12 levels in the brain in some individuals. B12-related anemia and neuropsychiatric side effects have been associated with these drugs. For this reason, a B12 supplement is suggested. [PMID: 21246600]

Vitamin B12 and Folate Labs: A Vitamin B12 lab test measures the levels of folate and vitamin B12 in your body. Folate and vitamin B12 are important nutrients that help your body make red blood cells and keep your nervous system healthy. Low levels of these nutrients can lead to anemia, fatigue, and other health problems. The Vitamin B12 & Folate test from Access Medical Labs (affiliate link) is available through the NutriScape Lab Shop.

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This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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