UltraFlora Control B420: A Probiotic for Weight Management

Keeping our weight down is one of the biggest health challenges for many of us. Scientists are exploring how changes in the bacteria in our guts might contribute to weight issues and are looking at specific good bacteria to use as probiotics that might help with weight control and overall metabolic health. A particular type of bacteria called Bifidobacterium animalis subsp. lactis 420, or B420 for short, has been studied in labs, animal tests, and in people.

And if B420 supplements are right for you, this article will show you the best place to buy B420 probiotic online. Supplement-Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements. In this article, we’ll summarize some of the research on B420 so that you can decide if it might be right for you.

The Research on B420

Research suggests that when the balance of bacteria in our gut is off, it can trigger inflammation and harm the lining of the gut. Bad bacteria can leak out, causing a low-level, widespread inflammation linked to obesity, known as metabolic endotoxemia. Studies show that B420 may help reduce this inflammation and the leakage by influencing various body signals and may also promote a healthier set of gut bacteria, especially in people who eat a lot of fatty, sugary foods.

Clinical trials with overweight people suggest that B420 can help manage weight, but more research is needed to be sure. The safety of B420, how well it can resist antibiotics, how stable it is in products, and whether it can survive in the gut to provide benefits, are all important factors being looked into. In short, B420 is promising as a part of the fight against obesity, but more studies are necessary to confirm its benefits. PMC7230722


In another study, scientists explored how a specific probiotic, Bifidobacterium animalis subsp. lactis 420 (B420), alone or combined with a type of dietary fiber called Litesse® Ultra polydextrose (LU), might affect body fat, particularly in the stomach area, and other factors linked to obesity. They recruited 225 healthy adults with body mass indices (BMIs) in the overweight range and randomly assigned them to one of four groups, including a placebo group, for a six-month treatment. They tracked changes in body fat using advanced body scanning and also monitored what participants ate and various health markers in their blood and stool.

In the study, a distinction emerged between the average results of all participants and those who adhered closely to the treatment regimen. While the general pool of participants didn’t show significant changes in body fat, the subset of individuals who followed the protocol diligently and avoided antibiotics did experience a notable decrease in body fat, particularly those receiving both the probiotic B420 and the fiber LU. This suggests that consistent use of these treatments could have a beneficial effect on body fat, especially around the abdomen. [PMC5264483]


A mouse study explored how Bifidobacterium animalis ssp. lactis 420 (B. lactis 420) could affect mice that were fed a diet high in fat to induce obesity and diabetes. The researchers found that mice given this probiotic didn’t gain as much weight and had better blood sugar control compared to those that didn’t get the probiotic. The probiotic also seemed to help lower levels of inflammation in the liver and reduce the presence of harmful substances (LPS, aka endotoxin) in the blood that come from bacteria in the gut. [PMID: 25062610]

What this means for humans is that B. lactis 420 might help manage weight and diabetes by improving gut health. Since this probiotic can lessen inflammation and the gut’s permeability, which means fewer harmful substances slip from the gut into the bloodstream, it could be a useful strategy in handling metabolic diseases related to obesity and poor blood sugar control. This connection highlights the role of a healthy gut microbiome in overall health, potentially influencing body weight and the risk of diabetes.

Buy Online

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

UltraFlora® Control by Metagenics

UltraFlora® Control is designed to help support body weight regulation by delivering targeted probiotic support as Bifidobacterium lactis B-420™††† which has been shown to help control body fat and body weight.*

Suggested Use:

Take one capsule per day or as directed by your healthcare practitioner as part of a healthy diet and exercise regimen.

Serving Size: 1 Capsule†

Amount Per Serving

Bifidobacterium lactis B420 Strain … 113.1 mg* (10 billion CFU)††

*Daily Value not established.

†Vegetarian capsule

††At date of expiration.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Bifidobacterium animalis ssp. lactis 420 (B420) shows promising benefits for weight management, addressing one of the key factors in the complex web of obesity and metabolic diseases. The ability of B420 to modify the gut environment, resulting in reduced weight gain and improved glucose metabolism, just goes to show the intricate connections between our diet, our gut microbiome, and overall health.

About the Author

Supplement Sciences

If you have any thoughts on this article, feel free to share them with us by emailing them to reviews@supplement-sciences.com.