Zinc Carnosine: From Peptic Ulcers & Leaky Gut To Ulcerative Colitis and Chemo

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Along with providing information on whether Zinc Carnosine supplements might be right for you, this article also links to Fullscript where you can buy Zinc Carnosine supplements online through the secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Zinc carnosine is recognized for its health advantages, particularly in digestive health. This article examines the scientific evidence supporting zinc carnosine’s role in addressing digestive issues, providing insights into its growing popularity among people seeking natural health solutions.

What Is Zinc Carnosine?

Carnosine is a natural compound found in muscles and the brain. It’s made up of two amino acids, beta-alanine and histidine, and is known for its ability to protect cells from damage caused by harmful molecules called free radicals.

Studies suggest that taking carnosine supplements may have several health benefits. For example, it could help maintain brain function and muscle performance as we age. Some research also shows that carnosine might support heart health by helping to regulate blood pressure and heart function.

Another potential benefit of carnosine is its ability to reduce inflammation in the body. Chronic inflammation is linked to various health issues, so anything that helps lower inflammation could be beneficial.

While more research is needed to fully understand how carnosine supplements work, early studies show promise for supporting overall health.

Zinc L-carnosine is a compound that protects and heals the digestive system by reducing inflammation and promoting tissue repair. It’s used to treat conditions like ulcers and mouth sores caused by chemotherapy, and it’s being studied for other digestive issues like ulcerative colitis and hemorrhoids.

What Are the Benefits of Zinc Carnosine?

  • Supports Digestive Health: Zinc carnosine maintains the stomach lining’s integrity, which can alleviate symptoms of gastritis and ulcers, providing relief from discomfort and promoting better digestion overall. [PMID: 35659631]
    • Promotes Gut Integrity: By strengthening the intestinal barrier, zinc carnosine reduces gut permeability, helping to alleviate symptoms associated with leaky gut syndrome such as bloating, food sensitivities, and digestive disturbances. [PMC6790068]
    • Aids Healing: Research suggests that zinc carnosine may accelerate the healing process of gastrointestinal tissues, promoting faster recovery from digestive disorders and reducing discomfort associated with these conditions. [PMC7146259]
  • Boosts Immune Function: Zinc carnosine supplements provide a readily absorbable form of zinc, which plays a crucial role in supporting immune cell function, enhancing the body’s ability to defend against infections and other challenges to immune health. [PMC7146259]
  • Possible Role In Cancer Therapy: zinc carnosine combines the neuroprotective properties of zinc with the benefits of carnosine, including its role in cancer resistance, crosslinking resistance, metal chelation, and oxidation limitation. It reduces free radical levels, inflammation, supplements zinc enzymes, and promotes wound healing and mucosal cell repair. [PMID: 35605299]
  • May Improve Cognitive Function: Some research suggests that zinc carnosine may have positive effects on cognitive function and memory, although more studies are needed to confirm these effects. [PMC10096773]
  • Supports Oral Health: Zinc carnosine may help maintain oral health by promoting gum health and reducing inflammation in the mouth. It has been found to help heal oral surgical wounds. [PMC10378135]

The Difference Between Zinc and Zinc Carnosine

Zinc is a vital mineral known for its immune-boosting and wound-healing properties, and it’s available in various forms, including plain zinc supplements. However, for specific health concerns, particularly those involving the digestive tract, Zinc Carnosine is considered a more specialized and effective option. Understanding the differences between plain zinc and Zinc Carnosine, along with why the latter is more beneficial for digestive issues, is crucial for anyone considering supplementation for gut health.

Plain Zinc typically refers to elemental zinc or zinc that is combined with another substance to form compounds like zinc oxide or zinc sulfate. These forms are effective for general health purposes, such as boosting the immune system or supporting metabolic function. However, plain zinc supplements are not specifically tailored to survive the acidic environment of the stomach or to target the lining of the gastrointestinal tract, which limits their effectiveness in treating digestive conditions.

Zinc Carnosine, on the other hand, is a chelated compound where zinc is molecularly bonded to carnosine, a dipeptide molecule consisting of the amino acids beta-alanine and histidine. This unique combination is specifically designed to withstand the harsh environment of the stomach. Once it reaches the small intestine, it dissociates, releasing zinc and carnosine to exert their beneficial effects directly on the gut lining.

Zinc Carnosine is notably more effective for digestive issues due to several key advantages over plain zinc. Firstly, the chelated form of Zinc Carnosine provides superior stability in the acidic conditions of the stomach. Unlike plain zinc, this stability allows Zinc Carnosine to pass through the stomach without degradation, reaching the intestines where it can exert its effects more efficiently. Once there, Zinc Carnosine adheres to the stomach and intestinal walls, directly targeting the mucosal lining. This targeted action is crucial for healing and strengthening the gut barrier, offering therapeutic benefits for conditions like gastritis, ulcers, and leaky gut syndrome.

Additionally, Zinc Carnosine exhibits anti-inflammatory properties that are particularly beneficial for inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. It actively helps reduce inflammation in the gut lining—a direct benefit that plain zinc does not offer. Furthermore, the presence of carnosine in Zinc Carnosine enhances the zinc’s wound-healing properties, promoting faster recovery of the gut mucosa from damage. Carnosine also acts as an antioxidant and has a buffering effect that can neutralize the stomach’s acidic environment, adding an extra layer of protection to the gut lining. These combined properties make Zinc Carnosine a highly effective supplement for addressing a range of digestive health issues.

So, Zinc Carnosine’s specific formulation makes it a superior choice for addressing digestive tract conditions. Its ability to withstand stomach acid, combined with its targeted, anti-inflammatory, and healing actions, provides a distinct advantage in promoting gastrointestinal health.

Food Sources of Zinc Carnosine

Zinc carnosine is primarily found in supplement form rather than naturally occurring in foods. However, the two components of zinc carnosine, zinc, and carnosine, can be obtained through dietary sources. Foods rich in zinc include oysters, red meat, poultry, beans, nuts, and whole grains. Carnosine is found in relatively small amounts in animal-based foods such as beef, pork, poultry, and fish. While zinc carnosine itself is not found in foods, incorporating zinc- and carnosine-rich foods into your diet can provide the individual components that make up this beneficial compound, supporting digestive health and overall well-being.

Is Zinc Carnosine Safe?

Zinc carnosine is safe for most people when taken at recommended doses. Research studies and clinical trials have demonstrated its safety profile, with few reported adverse effects. Furthermore, zinc carnosine is a naturally occurring compound found in various foods and is well-tolerated by the body. It is important to follow the dosage guidelines provided by healthcare professionals or supplement manufacturers to ensure safety and effectiveness. Overall, zinc carnosine offers a safe and effective option for promoting digestive and overall health.

Medication Interactions with Zinc Carnosine

  • Proton Pump Inhibitors (PPIs): PPIs may reduce the absorption of zinc, and could decrease the effectiveness of zinc carnosine supplements.
  • Antibiotics (such as Quinolone or Tetracycline antibiotics): Zinc supplements can interfere with the absorption of antibiotics, affecting their effectiveness. It’s advisable to take them at least 2 hours apart from zinc carnosine.
  • Thiazide Diuretics: Thiazide diuretics can increase the urinary excretion of zinc, possibly leading to lower zinc levels in the body when taken with zinc carnosine.
  • Immunosuppressants (such as Cyclosporine): Zinc supplements may enhance the immune system, and might counteract the effects of immunosuppressants. It’s essential to monitor zinc levels and adjust medication doses accordingly.
  • Penicillamine: Penicillamine can chelate with zinc, reducing its absorption and effectiveness when taken with zinc carnosine supplements.

Supplement Interactions with Zinc Carnosine

  • Calcium: Calcium supplements may interfere with the absorption of zinc, and may reduce the effectiveness of zinc carnosine. It’s advisable to take them at different times to avoid this interaction.
  • Iron: Iron supplements can compete with zinc for absorption in the body, possibly leading to decreased zinc levels when taken with zinc carnosine.
  • Copper: Zinc and copper compete for absorption in the body, so taking copper supplements alongside zinc carnosine may interfere with zinc absorption.
  • Magnesium: Magnesium supplements may interfere with zinc absorption, and may reduce the effectiveness of zinc carnosine. It’s best to take them at different times to avoid this interaction.
  • Multivitamin: Multivitamin supplements often contain various minerals, including zinc. Taking zinc carnosine alongside a multivitamin may result in excess zinc intake, leading to potential adverse effects.

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Zinc-Carnosine by Integrative Therapeutics

PepZinGI® Zinc-Carnosine Supplement

Zinc Carnosine contains the PepZinGI® brand of zinc-carnosine to support healthy gastrointestinal mucosa and relieve mild gastric discomforts.* After years of development, a Japanese company produced PepZinGI, a novel patented crystalline chelate compound consisting of L-carnosine and zinc.

The zinc-carnosine complex is typically dosed one 75 mg capsule twice per day. This provides 17 mg of elemental zinc twice daily.

PepZin GI® is a registered trademark of Hamari Chemicals, LTD

Suggested Use: Take 1 capsule twice daily, or as recommended by your healthcare professional.

Amount Per 1 Veg Capsule Serving
Zinc … 16mg
Zinc-Carnosine … 75mg (PepZin GI® brand)

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Incorporating Zinc Carnosine supplements into your routine can offer a range of health benefits. From supporting digestive health and promoting gut integrity to boosting immune function and aiding in tissue healing, Zinc Carnosine provides a natural way to enhance overall health. With its proven safety profile and ability to address various health concerns, Zinc Carnosine supplements serve as a valuable addition to a balanced lifestyle.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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