Small Intestinal Bacterial Overgrowth (SIBO): Your Guide To Supplement Solutions

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Along with providing information on whether supplements for Small Intestinal Bacterial Overgrowth might be right for you, this article also links to Fullscript where you can buy SIBO supplements online through the secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

When it comes to managing SIBO, dietary changes are paramount, but supplements can serve as valuable allies in the battle against symptoms and in promoting gut health. In this exploration, we’ll delve into the benefits of incorporating specific supplements into your SIBO management toolkit, drawing from scientific research and expert guidance.

What Is Small Intestinal Bacterial Overgrowth?

Small Intestinal Bacterial Overgrowth, often referred to as SIBO, is a gastrointestinal disorder that can disrupt the delicate balance of microorganisms within your digestive system. In SIBO, there is an overgrowth of bacteria in the small intestine, a part of the gut where bacterial concentrations should normally be relatively low. This overgrowth of bacteria can lead to a range of digestive symptoms and discomfort.

Common symptoms of SIBO include persistent abdominal bloating, often accompanied by a sensation of fullness, excessive gas production leading to frequent belching and flatulence, diarrhea due to the disruption of nutrient absorption in the small intestine, and abdominal pain or cramps of varying severity. Additionally, SIBO can result in nutritional deficiencies as impaired nutrient absorption may lead to a lack of essential vitamins and minerals, contributing to various health issues.

The underlying causes of SIBO can vary, but several common factors can trigger this condition. Impaired gut motility, as seen in conditions like irritable bowel syndrome (IBS) or certain surgeries, can disrupt the normal movement of the digestive tract and contribute to SIBO development. Low stomach acid levels can allow bacteria to survive the acidic environment of the stomach and proliferate in the small intestine. Structural abnormalities in the digestive tract, such as strictures or adhesions, can create pockets where bacteria accumulate. Some medications, particularly proton pump inhibitors (PPIs) that reduce stomach acid, may increase the risk of SIBO. Chronic illnesses like diabetes or autoimmune disorders can affect gut function, raising susceptibility to SIBO. Additionally, dietary factors play a role, with diets high in refined carbohydrates and sugars providing abundant food sources for bacteria, promoting their growth in the small intestine.

Recognizing the symptoms and understanding the potential causes of SIBO is the first step toward effective management and relief from digestive discomfort. If you suspect you may have SIBO, consulting with a healthcare provider or gastroenterologist is essential for proper diagnosis and treatment.

What Food and Lifestyle Factors Are Important For Managing Small Intestinal Bacterial Overgrowth?

  • Avoid Trigger Foods: Identify and avoid foods that exacerbate your SIBO symptoms. Common triggers may include high-sugar items, dairy products, high-fiber foods, and certain vegetables like broccoli, cauliflower, and cabbage. Refer to these SIBO Diet Recommendations.
  • Spacing out Meals: Meals should be spaced 3 to 4 hours apart to encourage the migrating motor complex to clear the small intestine.
  • Stress Management: Chronic stress can make SIBO symptoms worse. Incorporate stress-reduction techniques such as meditation, deep breathing exercises, or yoga into your daily routine to promote relaxation.
  • Hydration: Stay adequately hydrated, as water is essential for digestion and overall gut health. Proper hydration can help flush out toxins and support the mucosal lining of the intestines.
  • Avoid Alcohol and Caffeine: These substances can irritate the gastrointestinal tract and exacerbate SIBO symptoms. Reducing or eliminating alcohol and caffeine intake may provide relief.
  • Restorative Sleep: Prioritize getting enough restorative sleep, as poor sleep patterns can affect gut health and exacerbate SIBO-related symptoms.
  • Limit Antibiotic Use: Minimize the use of broad-spectrum antibiotics whenever possible, as they can disrupt the balance of gut bacteria and could contribute to SIBO.
  • SIBO-Specific Diet: In some cases, a healthcare provider may recommend a specific SIBO diet tailored to your condition. This diet may involve phases of restriction and reintroduction to identify trigger foods.
  • Lifestyle Modifications: Adjust your lifestyle to reduce factors that can contribute to SIBO, such as excessive alcohol consumption or smoking.

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. This article aims to offer valuable insights into which nutritional supplements have undergone scientific study and shown promise in supporting specific health conditions. We break down the research, so you can work with your medical providers to make informed decisions about adding supplements to your health regimen. For personalized advice tailored to your needs, we recommend consulting with a registered dietitian in addition to your primary care provider.

Check with your physician when adding supplements. While supplements are generally safe for most people, do not add nutritional supplements without your physician’s specific approval if you are pregnant or nursing, are undergoing cancer treatment, have a history of organ transplant, liver or kidney disease, or take medications that interact with supplements.


  • Berberine: Berberine may help manage SIBO by reducing bacterial overgrowth. It is believed to have antimicrobial properties that can target harmful bacteria in the small intestine, might reduce their numbers. [PMC9974661] Suggested dosage is 500 mg three times per day with food.
  • Oil of Oregano: Oil of oregano directly kills or strongly inhibits the growth of intestinal microbes. It can help reduce the overgrowth of bacteria in the small intestine. [PMC4030608] Suggested dosage is 2 or 3 times per day.
  • Probiotics: Probiotics, containing beneficial bacteria, were given to IBS patients with small intestinal bacterial overgrowth (SIBO), resulting in significant symptom improvement compared to those without SIBO. A study highlights the benefits of probiotics in managing IBS, especially when SIBO is involved, by restoring a healthy balance in the gut and reducing harmful bacterial overgrowth. [PMID: 28267052] Alternating different probiotic products and including probiotic foods is thought to be beneficial
  • Elemental Diet: An elemental diet consists of predigested nutrients that are easily absorbed in the small intestine, reducing the substrate available for bacterial overgrowth. This can be used to get an immediate reduction in overgrowth and can be combined with other supplement strategies that reduce microbial populations. [PMID: 14992438]
  • Herbal Combinations: A study found that herbal therapy was equivalent to antibiotic treatment for SIBO. Products studied included FC Cidal™ and Dysbiocide® by Biotics Research: 2 capsules of each twice daily. [PMC4030608] Consider using the SBO kit for 4 weeks and then switching to a combination of berberine, oil of oregano, and probiotics while following SIBO Diet Recommendations.
  • More:
    • Ginger: Ginger is a natural “prokinetic” that can help reduce SIBO symptoms. [PMID: 21218090]
    • L-Glutamine: L-Glutamine is an amino acid that supports gut health and may help repair the intestinal lining, which can be compromised in SIBO. It serves as an energy source for the cells lining the gut, promoting the repair and maintenance of the intestinal barrier. [PMC11013329]
    • Zinc: Zinc plays a role in gut lining repair and supports overall immune function, which can be compromised in individuals with SIBO. [PMC9313088] Zinc carnosine is possibly the best form of zinc for healing the digestive tract.
    • Betaine HCL: Betaine hydrochloride may support digestion by increasing stomach acid levels, which can help reduce bacterial overgrowth in the small intestine. [PMC7238915]
    • Digestive Enzymes: Digestive enzyme supplements can assist in breaking down food more efficiently, reducing symptoms like bloating and gas often experienced with SIBO. They work by aiding in the proper digestion of carbohydrates, proteins, and fats, ensuring that nutrients are absorbed in the small intestine, reducing the food available for bacterial overgrowth. [PMC2890937]
    • Peppermint Oil: Peppermint oil has been also used to alleviate symptoms of SIBO, possibly by relaxing the muscles of the gastrointestinal tract and reducing bacterial overgrowth. [PMID: 12410625]

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Are These Supplements for SIBO Safe?

Safety is a paramount consideration when using supplements to manage SIBO. Probiotics, digestive enzymes, L-Glutamine, Zinc, Vitamin D, B-vitamins, Berberine, Oil of Oregano, Allium Extracts (Garlic and Onion), Elemental Diet, Peppermint Oil, and Betaine HCL, when used as directed, generally have a good safety profile. However, it is always important to follow recommended dosages and seek guidance from a healthcare provider or registered dietitian, as individual responses can vary.

Medication Interactions:

  • Anticoagulants (e.g., Warfarin): Probiotics, digestive enzymes, L-Glutamine, zinc supplementation, certain B-vitamins like B6, berberine, oil of oregano, an elemental diet, peppermint oil, and betaine HCL may interact with anticoagulants, potentially affecting their effects or increasing bleeding risk.
  • Antidiabetic Medications (e.g., Metformin): Berberine, when combined with antidiabetic medications like metformin, may lower blood sugar levels, possibly causing hypoglycemia. Additionally, an elemental diet may interact with antidiabetic medications like metformin and affect blood sugar levels.
  • Blood Pressure Medications (e.g., ACE Inhibitors, Beta-Blockers): Peppermint oil may have blood pressure-lowering effects, which could be additive when taken with blood pressure medications, may lead to low blood pressure.
  • Cytochrome P450 Substrates (Various Medications Metabolized by CYP Enzymes): Berberine may interact with drugs metabolized by CYP enzymes, possibly affecting their levels in the body.
  • Gastric Acid Reducers (e.g., Proton Pump Inhibitors): Betaine hydrochloride is often used to support digestion by increasing stomach acid levels, which can possibly counteract the effects of gastric acid reducers.
  • Immunosuppressive Medications (e.g., Corticosteroids): Zinc supplementation may enhance immune function, and could affect the need for immunosuppressive medications.

Supplement Interactions

  • Probiotics: Probiotics can interact with digestive enzymes, possibly affecting their efficacy in breaking down food. Additionally, L-Glutamine may enhance the soothing effects of probiotics on the digestive tract.
  • Digestive Enzymes: Digestive enzymes can work alongside L-Glutamine to support gut health and soothe the digestive tract. Additionally, probiotics may complement the digestive benefits of enzymes by promoting a balanced gut microbiome.
  • L-Glutamine: L-Glutamine can enhance the soothing effects of probiotics on the digestive tract, while digestive enzymes may assist in breaking down food more efficiently when used with L-Glutamine.
  • Zinc: Zinc may support gut lining repair and immune function, and could complement the benefits of L-Glutamine for digestive health.
  • Vitamin D: Vitamin D may play a role in gut health and immune support, which can be important for managing digestive discomfort alongside L-Glutamine.
  • B-vitamins: B-vitamins are essential for overall health, including gut function, and may contribute to the benefits of L-Glutamine for digestive wellness.
  • Berberine: Berberine may work synergistically with L-Glutamine to support gut health and soothe digestive discomfort.
  • Oil of Oregano: Oil of oregano’s potential antimicrobial properties may complement the soothing effects of L-Glutamine on the digestive tract.
  • Allium Extracts (Garlic and Onion): Compounds in garlic and onion extracts, such as allicin, may have antimicrobial properties that can enhance the benefits of L-Glutamine for digestive health.
  • Elemental Diet: An elemental diet, in combination with L-Glutamine, can support gut health by reducing the substrate available for bacterial overgrowth.
  • Peppermint Oil: Peppermint oil’s potential to relax the muscles of the gastrointestinal tract may complement the soothing effects of L-Glutamine on the digestive tract.
  • Betaine HCL: Betaine hydrochloride can assist in digestion alongside L-Glutamine, possibly enhancing its digestive benefits.

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Probiotics, Digestive Enzymes, L-Glutamine, Berberine, Oil of Oregano, Allium Extracts (Garlic and Onion), Elemental Diet, Peppermint Oil, and Betaine HCL and a good multivitamin mineral supplement offer a range of benefits for managing Small Intestinal Bacterial Overgrowth (SIBO). These supplements, when used in combination with good food can be valuable tools in supporting digestive health and alleviating the symptoms associated with SIBO.

For the best personalized advice on using these supplements for SIBO, consult with a registered dietitian specializing in digestive health who can provide you with evidence-based recommendations and monitor your progress over time. Your journey to digestive health begins with informed decisions and the support of a qualified healthcare professional.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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