Niacinamide/Nicotinamide: Radiant Skin, Flexible Joints, and Endless Energy

Secure Ordering | Free Shipping | 20% Off Retail Prices

Along with providing information on whether Niacinamide/Nicotinamide supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.


In the realm of skincare, certain ingredients take the spotlight more than others. One such star ingredient that’s been gaining popularity is niacinamide. A powerhouse nutrient, niacinamide is a form of vitamin B3 that holds a significant place in the world of dermatology for its myriad benefits. In this article, we will delve into the benefits of niacinamide, uncovering why this ingredient has become an indispensable part of many skincare routines. Whether you’re looking to combat acne, reduce redness, or improve skin hydration, niacinamide may be the solution you’ve been searching for. Read on to learn more about this miracle worker of an ingredient and how it can transform your skincare routine.

What Is Niacinamide?

Niacinamide, also known as nicotinamide, is a form of vitamin B3. Vitamin B3 is an essential nutrient, which means our bodies need it to function properly but can’t produce it on their own, so we must get it from food or supplements. Niacinamide is found in various foods, like meat, fish, milk, eggs, green vegetables, and whole grains.

Niacinamide plays a vital role in many processes in our bodies, such as helping to convert food into energy, supporting the nervous system, and maintaining healthy skin. It is also used in skin care products because it can help improve the appearance of acne, fine lines, and uneven skin tone.

How Nicotinamide Differs From Niacin (Nicotinic Acid)

It can be confusing to keep track of the different forms of Vitamin B3, so the table below summarizes the differences.

NicotinamideNiacin
Other NamesNiacinamideNicotinic acid
Vitamin B3
Chemical StructureNicotinamide has an amide group (-CONH2) instead of a carboxyl group.Niacin has a carboxyl group (-COOH).
FunctionNAD Precursor: Nicotinamide is also used to form NAD.
Anti-Inflammatory: Nicotinamide has anti-inflammatory properties, making it useful for the treatment of acne.
Aging: Nicotinamide is also being researched for its potential in age-related diseases due to its role in maintaining cellular health.
NAD Precursor: Niacin form NAD, a coenzyme essential for various biological reactions.
Heart Health: Niacin supports cardiovascular health.
Side EffectsNo Flushing
Nicotinamide is generally better tolerated than niacin. It doesn’t cause “niacin flush” and is less likely to cause stomach upset. High doses can still potentially cause mild side effects, like dizziness or rash.
Flush and No Flush Varieties
Nicotinamide supplements are frequently used for treating skin conditions and are also being explored for potential anti-aging benefits and joint pain relief.
Dietary SourcesNicotinamide is present in similar foods as niacin, as they are both forms of Vitamin B3. It’s also available as a dietary supplement and can be synthesized in the body from tryptophan, an amino acid.Niacin is found in foods like meat, fish, whole grains, and green vegetables. It can also be taken as a dietary supplement.
Use in SupplementsNicotinamide supplements are frequently used for treating skin conditions and are also being explored for potential anti-aging benefits and joint pain relief.Niacin supplements are often used for lowering cholesterol levels and reducing cardiovascular disease risk.

What are the Benefits of Niacinamide?

Here’s a list of some potential health benefits of niacinamide:

  • Energy production: Niacinamide helps our bodies convert food into energy by raising NAD+ levels critical for energy production. [Science Direct: doi.org/10.1016/j.tma.2021.09.001]
  • Skin health: Niacinamide is used in skincare products because it can improve the appearance of acne, fine lines, and uneven skin tone. It may also help strengthen the skin’s protective barrier. [PMID: 34844552]
  • Joint health: Niacinamide has been studied for its potential to reduce inflammation and improve joint flexibility in people with osteoarthritis. [PMID: 8841834]
  • Cognitive function: Some research indicates that niacinamide may have a positive effect on cognitive function and may help protect against age-related cognitive decline. [PMC2617713]
  • Cholesterol management: Some studies suggest that niacinamide may help manage cholesterol levels. However, niacin is more effective for cardiovascular benefits.

Niacinamide/Nicotinamide in Acne Treatment

A lot of people are looking for new ways to treat acne because current treatments can have side effects and sometimes don’t work as well as they should due to increasing antibiotic resistance. Vitamin B3, also known as nicotinamide, might be a good option because it has strong anti-inflammatory properties, which can help calm down the skin.

Researchers reviewed scientific studies on the use of vitamin B3 for acne treatment. Out of 10 studies they found, most showed that using vitamin B3 on the skin led to a significant reduction in acne. Also, taking vitamin B3 as an oral supplement resulted in less acne in two studies. The good news is, no major side effects were reported. Yet, the researchers said more research will be needed before we can be sure that nicotinamide works for acne. [PMID: 28220628]

Dosages in most studies have used 4% nicotinamide cream applied to the skin twice daily or oral supplements containing 500 – 750 mg niacinamide per day taken in divided doses. Some studies have evaluated oral nicotinamide as part of a combined treatment, typically including other vitamins or zinc. This makes perfect sense because cells need so much more than niacin alone to maintain optimal function.

Niacinamide For Joint Pain

Researchers explored whether niacinamide can help people with osteoarthritis. This was a test of 72 people with osteoarthritis who didn’t know if they were taking niacinamide or a placebo.

After 3 months of supplementation with 3000 mg nicotinamide per day (split into 3 doses), researchers looked at several things including overall arthritis symptoms and pain, flexibility of the joints, and several blood tests. Overall arthritis symptoms improved in the group taking niacinamide but got a little worse in the placebo group. Pain levels stayed the same, but those taking niacinamide could reduce their usual pain medications a bit. Niacinamide also seemed to lessen inflammation (as shown by a blood test) and increase the flexibility of the joints compared to the placebo group. Some people experienced mild side effects, a bit more in the niacinamide group.

Researchers concluded that niacinamide could be helpful in treating osteoarthritis. It seemed to improve overall arthritis symptoms, increased joint flexibility, reduced inflammation, and allowed people to take a bit less of their usual pain medications. As always, more research is needed to confirm these findings and understand more about niacinamide’s effects on arthritis. [PMID: 8841834]

Niacinamide to Raise NAD+ Levels

As people age, levels of a crucial substance in the body, known as NAD+, naturally decrease. NAD+ is a pivotal molecule in cellular metabolism. A previous study discovered that consuming 200 mg of nicotinamide can help raise the levels of NAD+ in the blood.

In a new study, researchers aimed to find out if a higher dose of nicotinamide could similarly boost NAD+ levels. To explore this, a group of five healthy adults were given either 500 mg of nicotinamide or just water, and their blood NAD+ levels were analyzed before and after the treatment. The study showed that consuming 500 mg of nicotinamide significantly increased the NAD+ levels in the blood after 12 hours.

Researchers concluded that taking nicotinamide up to the safe daily amount can effectively boost NAD+ levels in the blood and may also alter the types of fats present in the blood. This strategy could be a beneficial way to counteract the natural decline in NAD+ that accompanies aging. [Science Direct: doi.org/10.1016/j.tma.2021.09.001]



Is Niacinamide/Nicotinamide Safe?

Niacinamide is generally considered safe for most people and toxicity is not a concern. However, there are some medications that may interact with niacinamide. Below is a list of a few medications that might interact with niacinamide and the severity of each interaction:

  • Carbamazepine (Tegretol): Niacinamide might increase the body’s breakdown of carbamazepine, a medication used to treat seizures and nerve pain. This interaction could potentially reduce the effectiveness of carbamazepine
  • Primidone (Mysoline): Similar to carbamazepine, niacinamide might increase the body’s breakdown of primidone, which is also used to treat seizures. This interaction might decrease the effectiveness of primidone.
  • Anticoagulant / antiplatelet medications:Niacinamide might affect blood clotting. When taken with anticoagulant or antiplatelet medications like warfarin, aspirin, or clopidogrel, it could increase the risk of bleeding.

Food Sources of Niacinamide

Niacinamide, also known as nicotinamide, is a form of vitamin B3 found in various foods. Here’s a table showing some common food sources of niacinamide and the approximate amount of niacinamide in each:

Food SourceApproximate Amount of Niacinamide (mg 3 oz/100 g Serving)
Turkey, cooked14.3
Chicken breast, cooked13.6
Tuna, canned in water11.3
Salmon, cooked8.5
Beef, cooked7.6
Pork, cooked6.9
Peanuts, roasted13.1
Sunflower seeds8.3
Brown rice, cooked1.8
Whole wheat bread2.2
Green peas, cooked2.0
Spinach, cooked0.6
Milk, whole0.8
Eggs, cooked0.6
Please note that these amounts are approximate and can vary depending on the specific type and preparation of the food.

Order Nicontiamide (Niacinamide)

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Niacinamide (Thorne)

Manufacturer product information: Niacinamide, also known as nicotinamide, is a non-flushing form of vitamin B3. Niacinamide has multiple positive functions in the body, including supporting restful sleep and healthy joint and skin.* It also acts as an antioxidant, inhibiting free radical formation, and it has been shown to promote the regeneration of beta cells in the pancreas.* Niacinamide has been found to stimulate neurotransmitter receptors in the brain, without binding to the receptor sites, which creates a calming, sedative-like effect.* High amounts of niacinamide have been documented as being beneficial in protecting joint cartilage cells.* Niacinamide has also been used in support of several dermatological conditions.* Niacinamide is not derived from yeast.

Take 1 capsule one to three times daily or as recommended by your health professional.

Serving Size: 1 Capsule

Amount Per Serving
Vitamin B3
 … 500mg (Niacinamide)

To Sum It Up

It’s clear that niacinamide holds a vital place in the fight against aging. The benefits of niacinamide, ranging from boosting skin barrier function to its vital role in reducing wrinkles and fine lines, make it a noteworthy ally in promoting youthful skin. Its ability to improve skin elasticity, stimulate collagen production, and fight oxidative stress further strengthens its position as an essential ingredient in anti-aging skincare. As we have explored throughout this article, niacinamide stands as a transformative component that can significantly aid in slowing down the clock on skin aging. So, whether you’re beginning your journey into anti-aging skincare or you’re looking for effective solutions to maintain your skin’s youthfulness, don’t overlook the potential of niacinamide. Here’s to embracing age with grace, confidence, and the power of niacinamide!

About the Author

Supplement Sciences

Staff Authors at Nutriscape have been working on this article and it is still a work in progress. Please feel free to login and comment on what you see so far.

Leave a Reply