Lactobacillus Plantarum 299v: Improved Iron Status, IBS, and Mood

Lactobacillus plantarum 299v is a specific strain of probiotic bacteria that’s been the subject of a good deal of scientific research. This bacteria strain is known for its gut-balancing properties and has been studied for its role in improving iron absorption, boosting mood, and even aiding digestive health. While it’s not a cure-all, understanding how Lactobacillus plantarum 299v works can offer insights into maintaining a healthier lifestyle. If this probiotic is right for you, this article will show you the best place to buy Lactobacillus plantarum 299v online. Supplement-Sciences has partnered with Fullscript’s professional-grade supplement formulary to provide a 20% discount on every order, so you always have access to the highest quality supplements. This article will dive into the science-backed benefits of this interesting probiotic.

What Is Lactobacillus Plantarum 299v?

Lactobacillus Plantarum 299v is a strain of probiotic bacteria that offers numerous health benefits. It’s naturally found in certain fermented foods like sauerkraut, pickles, and sourdough bread. This particular strain has gained attention for its ability to promote digestive health and support the immune system. Research shows that Lactobacillus Plantarum 299v helps alleviate symptoms of digestive issues such as bloating, gas, and diarrhea. Additionally, it has been studied for its potential to strengthen the body’s natural defenses against harmful pathogens. Overall, Lactobacillus Plantarum 299v supplements can be a valuable addition to a healthy lifestyle, aiding in maintaining optimal gut health and immune function.

What Are the Benefits of Lactobacillus Plantarum 299v?

  • Improves Iron Absorption: Lactobacillus Plantarum 299v aids in absorbing essential nutrients like iron, which is crucial for various bodily functions. Iron is necessary for the formation of red blood cells and the transport of oxygen throughout the body. A study cited in [PMC5728536] suggests that by promoting the absorption of iron, this probiotic strain supports overall health.
  • Supports Digestive Health:  Lactobacillus Plantarum 299v is known to alleviate symptoms related to digestive disorders such as Irritable Bowel Syndrome (IBS). Research shows that this probiotic strain can help regulate bowel movements, reduce abdominal discomfort, and improve overall digestive function. [PMID: 33556972]
  • Boosts Immune System: By supporting a balanced immune response, Lactobacillus Plantarum 299v enhances the body’s natural defenses against pathogens and infections. Research suggests that this probiotic strain helps modulate the immune system, increasing the production of antibodies and enhancing immune function, ultimately promoting overall wellness.
  • Elevates Mood: Some research suggests that Lactobacillus Plantarum 299v has a positive effect on mood and mental health. The gut-brain axis, which refers to the bidirectional communication between the gut and the brain, plays a significant role in mood regulation. By influencing gut health, Lactobacillus Plantarum 299v may indirectly impact mood and emotional health. [PMID: 30388595]
  • Anti-inflammatory Properties: Lactobacillus Plantarum 299v helps reduce inflammation in the gut, contributing to overall digestive comfort. Chronic inflammation in the gut can lead to various digestive disorders and discomfort. By exerting anti-inflammatory effects, this probiotic strain promotes a healthier gut environment, reducing the risk of gastrointestinal issues and enhancing overall health. [PMC6205737]
  • Lowers Cardiovascular Risk Factors: A study in smokers showed that Lactobacillus plantarum 299 reduced blood pressure, clotting factors, and inflammatory markers. [PMID: 12450890] These findings suggest that this probiotic strain may have beneficial effects on cardiovascular health by improving blood pressure, reducing clotting risk, and decreasing inflammation, ultimately lowering the risk of cardiovascular diseases.

Research on Iron and Female Athletes

Low iron stores are common among athletes, necessitating supplementation. Traditional oral iron supplements have limitations; they’re not fully absorbed by the gut, which sometimes leads to constipation. A recent study explored the impact of combining the probiotic strain Lactobacillus plantarum 299v (Lp299v) with a 20 mg iron supplement. In this study involving 53 non-anemic athletes, the researchers concluded that combining Lp299v with 20 mg of iron could offer a more effective strategy for improving iron status. [PMC7282001]

Possible Food Sources of Lactobacillus Plantarum?

Food SourceAmount of Lactobacillus Plantarum 299v per Serving
Fermented Pickles1 billion CFU
Sauerkraut1-10 billion CFU
Sour Sourdough Bread100 million to 1 billion CFU
Fermented Vegetables100 million to 1 billion CFU
Kimchi1-10 billion CFU
Note: CFU stands for Colony Forming Units, which is a measure of viable bacteria present in a sample. The amounts provided are approximate and can vary depending on factors such as fermentation time, preparation methods, and storage conditions.

Is Lactobacillus Plantarum 299v Safe?

Lactobacillus Plantarum 299v supplements are safe and effective. Extensive research and clinical studies have demonstrated that this probiotic strain is well-tolerated and does not have any significant safety concerns for most people. As a naturally occurring bacterium in the human gut and commonly found in fermented foods, Lactobacillus Plantarum 299v is a safe dietary supplement when consumed as directed. Moreover, it has a low risk of adverse effects, making it suitable for long-term use in promoting digestive health and supporting overall health. Overall, Lactobacillus Plantarum 299v supplements offer a safe and effective option for enhancing gut health and maintaining a balanced microbiome.

Medication Interactions with Lactobacillus plantarum 299v

Any medication that impacts the gut flora will, by definition, interact with Lactobacillus plantarum, so this is not an exhaustive list. Individual responses will vary because of the complex interactions in each person’s unique microbiome.

  • Antibiotics: Lactobacillus Plantarum 299v supplements may interact with antibiotics, and may reduce their effectiveness. Antibiotics can kill harmful and beneficial bacteria, including probiotics like Lactobacillus Plantarum 299v, leading to decreased effectiveness of the probiotic supplement.
  • Immunosuppressants: Lactobacillus Plantarum 299v supplements may interact with immunosuppressant medications, possibly altering the body’s immune response. Immunosuppressants work by suppressing the immune system to prevent rejection of transplanted organs or treat autoimmune diseases. Probiotics like Lactobacillus Plantarum 299v may modulate immune function.
  • Antifungal Medications: Lactobacillus Plantarum 299v supplements may interact with antifungal medications, which might reduce their effectiveness. Antifungal drugs work by targeting fungal infections, but they can also affect the balance of beneficial bacteria in the gut, including probiotics like Lactobacillus Plantarum 299v.

Supplement Interactions with Lactobacillus Plantarum 299v

  • Probiotics: Lactobacillus Plantarum 299v supplements may interact with other probiotic supplements, which may lead to an imbalance in gut bacteria or competition for resources. While probiotics are safe, taking multiple strains may not provide additional benefits and could disrupt the natural balance of the gut microbiota.
  • Prebiotics: Prebiotics, contain non-digestible fibers that serve as food for beneficial gut bacteria, and may interact with Lactobacillus Plantarum 299v supplements. While prebiotics can support the growth of probiotics like Lactobacillus Plantarum 299v, excessive consumption may cause digestive discomfort or bloating.
  • Digestive Enzymes: Lactobacillus Plantarum 299v supplements may interact with digestive enzyme supplements, possibly affecting the breakdown and absorption of nutrients in the digestive tract. While some people may benefit from probiotics and digestive enzymes, it’s essential to monitor for any adverse effects or changes in digestive function.
  • Fiber Supplements: Fiber supplements, which provide additional dietary fiber to support digestive health, may interact with Lactobacillus Plantarum 299v supplements. While fiber is essential for promoting the growth of beneficial gut bacteria, excessive intake may lead to digestive discomfort or gas when combined with probiotics.

Order Lactobacillus Plantarum 299v Online

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PRO-IBS Support by Hyperbiotics

Manufacturer Description: PRO-IBS Support* features a highly stable and patented probiotic strain, Lactiplantibacillus plantarum 299V, combined with Boswellia serrata extract to improve absorption and utilization. This unique combination formula is designed to stabilize gut function while providing accelerated and prolonged relief from occasional bloating, gas, and irregularity.*

In one simple capsule per day, PRO-IBS Support* works to effectively stabilize gut discomfort and dysfunction in those with irritable bowel syndrome (IBS), while providing accelerated and prolonged relief from bloating, gas, and irregularity.*  Each capsule contains 30 billion CFUs of Lactiplantibacillus plantarum 299v, the clinically effective dose and strain used in over 65 clinical studies combined with highly bioavailable, lecithin-based Boswellia serrata extract (125mg) in a clinically studied dose range with standardized phytoactives.

PRO-IBS Support* is vegan, non-GMO, and free of dairy, gluten, soy, nuts, sesame, and active yeast. Contains no added sugar, artificial flavors, artificial colors, or preservatives.

Suggested Use: Take 1 capsule per day on an empty stomach.

Amount Per 1 Capsule Serving
Lactiplantibacillus plantarum 299v … 85 mg
(LP299V®) (30 Billion CFU)
Indian Frankincense Phytosome … 125 mg
(Boswellia serrata Extract, oleo-gum-resin, standardized to 25% triterpene acids and 10% beta boswellic acids))

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

“To Sum It Up”

Lactobacillus Plantarum 299v supplements offer a range of health benefits. From supporting digestive health and alleviating symptoms of digestive disorders like IBS to boosting the immune system and reducing inflammation, this probiotic strain plays a crucial role in maintaining overall health. Lactobacillus Plantarum 299v may improve nutrient absorption, enhance mood, and even lower cardiovascular risk factors. By promoting a balanced gut microbiome, these supplements contribute to digestive comfort and immune resilience, ultimately supporting a healthier, happier you.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


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