Hyaluronic Acid: Your Key to Radiant Skin and Joint Health

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Along with providing information on whether Hyaluronic Acid supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Hyaluronic acid is found naturally in the body. It plays a pivotal role in maintaining healthy skin, joints, and more. In this article, we delve into the science behind Hyaluronic Acid supplements and explore their potential benefits, from promoting skin hydration and elasticity to supporting joint comfort.

What Is Hyaluronic Acid?

Hyaluronic Acid, often abbreviated as HA, is a natural substance found in the human body, primarily in the skin, joints, and eyes. It’s a glycosaminoglycan, a molecule that can hold a remarkable amount of water, making it a vital component for maintaining hydration and structure in various tissues. In the skin, Hyaluronic Acid helps keep it plump, moist, and youthful by retaining moisture, contributing to a healthy, radiant complexion. Moreover, in the joints, it acts as a lubricant and shock absorber, aiding in smooth and pain-free movement. As we age, our natural Hyaluronic Acid levels decline, which can lead to skin dryness, wrinkles, and joint discomfort. Hyaluronic Acid supplements have gained popularity for their potential to replenish these essential stores, promoting skin health and joint comfort.

What Are the Benefits of Hyaluronic Acid?

  • Skin Hydration: Hyaluronic Acid supplements are known for their ability to retain moisture in the skin, helping to keep it hydrated, supple, and youthful. [PMC5522662]
  • Wrinkle Reduction: By maintaining skin moisture levels, Hyaluronic Acid may reduce the appearance of fine lines and wrinkles, promoting a smoother complexion. [PMC8308347]
  • Joint Health: Hyaluronic Acid acts as a natural joint lubricant, potentially easing joint discomfort and promoting better mobility, making it a valuable asset for those with arthritis or joint issues. Analysis of a randomized trial showed, “a highly significant reduction in chronic pain scores was seen after 2 weeks of consumption of three tablespoons [225 milligrams (mg) HA] of active product.” [PMC4281855]
  • Eye Health: HA is found in the eye’s vitreous humor and can help maintain eye structure and function, potentially supporting overall eye health. [PMC6778932]
  • Wound Healing: Hyaluronic Acid (HA) is the main component of extracellular matrix and it’s considered to be one of the key players in the tissue regeneration process. It has been proven to modulate inflammation, cellular migration, and new blood vessel growth, which are the main phases of wound healing. [PMID: 26978861]
  • Receding Gums: A systematic review concluded that treatment with “HA gel for root coverage could be clinically beneficial”. [PMC9658310] It may aid in maintaining healthy gums by supporting tissue integrity.
  • Hair Health: Some individuals use hyaluronic acid to support healthy hair growth and overall hair health. [PMC8347214]
  • Bone Health: Although research is still in the animal testing phase, there is some evidence that Hyaluronic Acid may have a role in bone healing and bone density. [PMID: 23256527]

These health benefits make Hyaluronic Acid supplements a versatile option for individuals looking to enhance their skincare regimen, alleviate joint discomfort, and potentially support various aspects of overall health and well-being.

Food Sources of Hyaluronic Acid

Food SourceAmount of Hyaluronic Acid per Serving (mg)
Bone Broth1000-2000 mg
Chicken Skin200-300 mg
Organ Meats100-500 mg
Fish (salmon, tuna)100-400 mg
Soy-based Foods50-200 mg
Leafy GreensTrace amounts
Sweet PotatoTrace amounts
Citrus FruitsTrace amounts
Keep in mind that these amounts can vary based on preparation methods and other factors.

Is Hyaluronic Acid Safe?

Oral hyaluronic acid supplements are safe for most people. Since hyaluronic acid is a substance naturally occurring in the body, it’s typically well-tolerated when taken in supplement form.

Medications Interaction with Hyaluronic Acid

For oral hyaluronic acid supplements, specific interactions with medications are not well-documented in scientific literature. Most known interactions with hyaluronic acid are related to its injectable form rather than oral supplements. For example, injectable hyaluronic acid is commonly used in cosmetic procedures and joint treatments, and there are guidelines around using it with blood thinners or anti-inflammatory medications to prevent excessive bleeding or bruising.

Supplements Interaction with Hyaluronic Acid

Some supplements that could theoretically interact based on their blood thinning and antiinflammatory effects include fish oil, garlic, ginkgo biloba, and curcumin. Glucosamine is often used in conjunction with hyaluronic acid for joint health, but the effects of using both together are not well-studied.

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Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
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    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

How Much Hyaluronic Acid Should You Take?

Hyaluronic Acid Dosage: The recommended dosage for oral supplements can vary by product, but typical doses range from 100 to 200 milligrams per day.

Hyaluronic Acid (100mg) w/ MSM (900mg) by NOW Foods

Manufacturer description: Hyaluronic Acid is a compound present in every tissue of the body, with the highest concentrations occurring in connective tissues such as skin and cartilage.* Hyaluronic Acid is an important constituent of joint fluid, where it serves as a lubricant and plays a role in resisting compressive forces.* MSM was added to this product as a natural sulfur compound, offering the chemical links needed to form and maintain connective tissues in the human body including articular cartilage.* Natural color variation may occur in this product. Take 2 capsules 1 to 2 times daily with food.

Amount Per 2 Veg Capsule Serving
Sodium … 10mg (from Sodium Hyaluronate)
Hyaluronic Acid … 100mg (from Sodium Hyaluronate)
MSM … 900mg (Methylsulphonylmethane)

Hyaluronic Acid 100mg by Patient One MediNutritionals

Manufacturer Description:

Patient One Hyaluronic Acid is derived from a vegetarian source, produced through fermentation. While in nature sodium hyaluronate is a high molecular weight polysaccharide, ranging from thousands to millions Dalton, our formula supplies a low molecular weight source for ease of absorption in the small intestines and optimal utilization by the body.

Promotes joint lubrication and comfort and supports hydrated, youthful skin

  • Thickens synovial fluid and optimizes connective tissue health
  • Supports joint flexibility and comfort
  • Nourishes and hydrates collagen
  • Promotes smooth, healthy skin
  • Vegetarian formula


  • Balazs EA, Denlinger JL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol Suppl 1993;39:3–9.
  • Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 2003;5:54–67.
  • Wobig M, Dickhut A, Maier R, Vetter G. Viscosupplementation with hylan G-F 20: a 26-week controlled trial of efficacy and safety in the osteoarthritic knee. Clin Ther 1998;20:410– 23.
  • Huskisson EC, Donnelly S. Hyaluronic acid in the treatment of osteoarthritis of the knee. Rheumatology (Oxford) 1999;38: 602–7.
  • Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid onosteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg Am 2004;86-A:538–45.

Take 2 capsules daily as a dietary supplement, with or between meals, or as directed by a qualified health care professional.

Serving Size: 2 Capsules

Amount Per Serving
Hyaluronic Acid … 100mg (as Sodium Hyaluronate)

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Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Hyaluronic acid supplements can improve skin hydration, making your skin look plumper and reducing the appearance of fine lines. These supplements also support joint health by providing lubrication and cushioning between the bones. With benefits for both skin and joints, hyaluronic acid offers a targeted approach to improving these aspects of health.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to reviews@supplement-sciences.com

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