Beta Blocker Interactions: CoQ10 May Be Depleted

Beta blockers, also known as beta-adrenergic blocking agents, are a class of medications commonly used to treat cardiovascular conditions, including high blood pressure, heart rhythm disorders, and heart failure. Here’s a list of some beta blockers available in the United States:

  • Atenolol (Brand name: Tenormin)
  • Metoprolol (Brand names: Lopressor, Toprol XL)
  • Propranolol (Brand names: Inderal, Inderal LA, InnoPran XL)
  • Carvedilol (Brand names: Coreg, Coreg CR)
  • Bisoprolol (Brand name: Zebeta)
  • Nadolol (Brand name: Corgard)
  • Sotalol (Brand names: Betapace, Sorine, Sotylize)
  • Timolol (Brand names: Blocadren, Timolide)
  • Nebivolol (Brand name: Bystolic)
  • Labetalol (Brand names: Normodyne, Trandate)

These medications work by blocking the effects of epinephrine (adrenaline) on the heart and blood vessels, which leads to a decrease in heart rate and blood pressure. Different beta blockers may have specific uses and properties, making some more suitable for certain conditions than others.


Drug-Induced Nutrient Depletion:

  • Coenzyme Q10Beta Blockers can deplete CoQ10. If you are taking a Beta Blocker such as Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Labetalol, or others, you may benefit from 100 mg CoQ10.  [PMID: 17892] [PMC4112525]

Drug-Nutrient Interactions: 

  • CoQ10 and Fish Oil: These Supplements can reduce blood pressure. If you are taking blood pressure medicines, be careful to monitor blood pressure when adding CoQ10 and Fish Oil.
  • Garlic, Ginkgo biloba & St. John’s Wort: These have the potential to affect the metabolism or clearance of blood pressure medicines.
  • Potassium: Some beta-blockers can increase potassium levels in the blood, so potassium supplements or high-potassium foods might worsen this effect.

Other Interactions To Know

  • Licorice: Consuming large amounts of natural licorice (not sold in the US) can decrease the effectiveness of some beta blockers and increase blood pressure.
  • Alcohol: Alcohol can enhance the blood pressure-lowering effect of beta blockers, leading to hypotension (low blood pressure) and increased risk of dizziness or fainting.
  • Caffeine: Beta blockers can sometimes exaggerate the effects of caffeine, leading to increased heart rate and blood pressure.
  • NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): NSAIDs can reduce the blood pressure-lowering effect of beta blockers.
  • Antacids: Some antacids, particularly those containing aluminum or magnesium, can affect the absorption and effectiveness of beta blockers.

It’s important for individuals on beta blocker therapy to consult with their healthcare provider before starting any new supplements or making significant dietary changes. The healthcare provider can provide guidance to ensure that supplements and dietary choices do not adversely interact with the medication.

About the Author

Supplement Sciences

If you have any thoughts on this article, feel free to share them with us by emailing them to

Leave a Reply