Bergamot Polyphenols: Heart, Brain, and Blood Sugar

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Bergamot polyphenols, compounds derived from the bergamot fruit, have captured the interest of many seeking natural health solutions. Known for their distinctive fragrance, these substances are more than just a pleasant scent; they have a rich profile of health-promoting properties. This article dives into the science behind bergamot polyphenols, shedding light on how they can support overall health and contribute to a balanced lifestyle. Join us as we explore the array of benefits these citrus-derived nutrients offer.

What Is Bergamot?

Bergamot polyphenols are active compounds found in the bergamot orange (Citrus bergamia), a fragrant citrus fruit primarily grown in the coastal regions of southern Italy. The fruit’s unique profile of polyphenolic compounds—antioxidant substances also found in green tea and red wine—accounts for its health benefits. These compounds include flavanones like naringin, neohesperidin, and hesperetin, which are known for their potential to support cardiovascular health, balance blood sugar levels, and provide antioxidant protection.

Unlike other citrus fruits, bergamot boasts an unusually high concentration of these polyphenols, which is why it’s often processed into supplements to maximize intake. The supplements usually come in the form of extracts, which are standardized to contain a certain percentage of polyphenols, ensuring a consistent dose of the active ingredients that contribute to their health effects. The use of bergamot polyphenols in supplement form aims to harness these benefits in a concentrated, easy-to-consume manner.

What Are the Benefits of Bergamot Polyphenols?

  • Support Cardiovascular Health: They help maintain healthy cholesterol levels and support artery function.
  • Antioxidant Properties: Protect cells from oxidative stress and damage caused by free radicals.
  • Promote Healthy Blood Sugar Levels: Assist in managing blood glucose levels, beneficial for those monitoring their sugar intake. [PMID: 30501605]
  • Support Metabolic Health: Contribute to metabolic processes that maintain a healthy weight and overall wellness.
  • Skin Health: Topical applications have been noted to promote skin health due to antioxidant and anti-inflammatory properties.
  • Mood and Cognitive Benefits: Some studies suggest bergamot polyphenols may have a positive effect on mood and cognitive function.
  • Antimicrobial Activity: Exhibits potential in fighting certain bacteria and viruses.
  • Stress Reduction: Some studies suggest that bergamot polyphenols may help reduce stress and anxiety levels.
  • Anti-inflammatory Effects: These supplements might help reduce inflammation in the body, which is beneficial for chronic diseases and overall health.
  • Digestive Health: They may also aid in digestion and support gut health by influencing gut flora and reducing inflammation.
  • Neuroprotective Properties: There’s emerging evidence that bergamot polyphenols may have a role in protecting nerve cells, which could be significant for neurodegenerative diseases. [PMC7238189]
  • Liver Health: They may help in maintaining liver health by assisting in the management of certain enzymes and processes in the liver.

Food Sources of Bergamot Polyphenols

Food SourcePart UsedAmount of Polyphenols per Serving
Bergamot OrangePeel (for extract)Varies (extracts are standardized)
Bergamot Orange TeaDried Peel/ExtractVaries (depends on infusion time and amount)
Earl Grey TeaFlavoring (Oil of Bergamot)Minimal; used for flavor, not a significant polyphenol source

Is Bergamot Safe?

Bergamot polyphenols, derived from the bergamot orange, are generally considered safe when consumed in amounts typically found in food and beverages, like Earl Grey tea. When it comes to supplements, those containing bergamot polyphenols are deemed safe for most people when taken according to the recommended dosages. The extraction process focuses on capturing the beneficial compounds without harmful elements. Side effects are rare, and when they occur, they are typically mild. Nonetheless, as with any supplement, it’s wise to be aware of your body’s responses and any changes that occur with new supplements in your routine.

Medication Interactions with Bergamot

  • Statins (Cholesterol-Lowering Medications): Bergamot polyphenols may enhance the effect of statins, increasing the risk of side effects like muscle weakness.
  • Cytochrome P450 Substrates: Bergamot can inhibit enzymes in the cytochrome P450 family, potentially increasing the levels of drugs metabolized by these enzymes, leading to increased effects and side effects.
  • Calcium Channel Blockers: Used for high blood pressure and heart conditions, bergamot might increase the risk of hypotension (low blood pressure) and bradycardia (slow heart rate) when taken with these drugs.
  • Anticoagulants (Blood Thinners): May increase the risk of bleeding when taken with bergamot polyphenols.
  • Antihypertensives (Blood Pressure Medication): Bergamot may augment their blood pressure-lowering effects, which could lead to hypotension.

Supplement Interactions with Bergamot

  • Herbs and Supplements that Lower Blood Pressure: Like hawthorn, garlic, and coenzyme Q10, may increase the risk of blood pressure dropping too low when taken with bergamot polyphenols.
  • Other Antioxidant Supplements: Such as green tea extract or resveratrol, might have additive effects with bergamot polyphenols, potentially intensifying their impact.
  • Blood-Thinning Supplements: Such as ginkgo biloba, ginger, and omega-3 fatty acids, could potentially increase the risk of bleeding when combined with bergamot polyphenols.
  • Supplements that Affect Blood Sugar Levels: Like cinnamon or alpha-lipoic acid, could have combined effects, potentially leading to hypoglycemia when taken with bergamot polyphenols.
  • Cytochrome P450 Metabolized Supplements: Bergamot polyphenols might alter the metabolism of other supplements that are processed by the same liver enzymes, which could affect the efficacy and side effects of those supplements.

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Bergamot BPF by Ortho Molecular Products

  • Promotes Healthy Cholesterol Levels
  • Multidimensional Support for Cardiovascular Health
  • Preserves Arterial Health and Elasticity
  • Supports Healthy CoQ-10 Levels

Optimizing cardiovascular health is a leading concern for many adults, and maintaining balanced cholesterol levels are an important part of that process. Though cholesterol can be consumed through food, circulating cholesterol levels are primarily produced and controlled by the liver using the rate control enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies.

Numerous clinical trials have shown the specific BPF found in Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels and preserve coronary arteries by maintaining normal inflammatory balance.


Suggested Use: Take 2 capsules per day or as recommended by your health care professional.

Serving Size: 2 Capsules

Amount Per Serving
Bergamot Orange Extract … 1g
(Citrus bergamia)(Fruit)(Bergamonte®) 
(38% Bergamot Polyphenolic Fraction® comprised of Neohesperidin, Naringin, Neoeriocitrin, Brutieridin, and Melitidin)

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Bergamot polyphenols bring a unique blend of benefits, from supporting healthy cholesterol levels to offering antioxidant properties that protect cells from damage. They also play a role in blood sugar regulation and may contribute to cardiovascular health. With these promising health benefits, bergamot polyphenol supplements can be a valuable addition to one’s wellness routine, providing the essence of the bergamot fruit in a concentrated form. As with any supplement, it’s important to consider your overall health goals and dietary needs when deciding whether bergamot polyphenols are right for you.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.

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