Author: Stephanie Figon, MS, RDN, LD

Founder of NutriScape.NET. As a dietitian since 1992, Steph Figon has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Connect on Linkedin

Antipsychotics (Abilify®, Haldol®, Seroquel®, Risperdal®, Zyprexa®): Drug-Nutrient Interactions To Know

Antipsychotic medications such as Abilify® (aripiprazole), Haldol® (haloperidol), Seroquel® (quetiapine), Risperdal® (risperidone), and Zyprexa® (olanzapine) are pivotal in treating psychiatric disorders. Their effectiveness and the patient’s nutritional status can be influenced by interactions with vitamins, minerals, and herbal supplements.

Drug-Nutrient Interactions:

  • Vitamin D and Calcium: Antipsychotics, particularly those associated with weight gain and metabolic changes like Zyprexa® and Seroquel®, can impact bone density. Adequate intake of vitamin D and calcium is crucial for maintaining bone health, especially since some patients on long-term antipsychotic therapy may be at increased risk for osteoporosis. However, Vitamin D supplements reduce serum concentrations of antipsychotic medications, therefore monitoring of serum medication levels is recommended. [PMID: 35380747]
  • B Vitamins: B vitamins, particularly folate (B9), B6, and B12, play roles in neurological function and mental health. Antipsychotics may influence the metabolism of these vitamins, potentially necessitating supplementation to support overall brain health and reducing side effects like fatigue or cognitive impairment.
  • Magnesium: This mineral is vital for many bodily functions, including nerve transmission and muscle relaxation. Some antipsychotics may affect magnesium levels, leading to side effects such as muscle spasms or weakness, and supplementation might be beneficial in some cases.
  • Omega-3 Fatty Acids: While not an herbal supplement, omega-3s are important for mental health and may interact with antipsychotic medications by potentially enhancing mood stabilization. However, they should be used cautiously and under medical supervision to ensure they don’t interfere with the therapeutic effects of the medications.

Herbal Supplement Interactions:

  • St. John’s Wort: Known to affect the metabolism of many drugs, this herb can reduce the effectiveness of antipsychotics by increasing their breakdown in the liver, particularly relevant for drugs like Abilify® and Seroquel®.
  • Other Herbals: Any herbal supplements should be carefully discussed with your physician because many interactions are possible. Don’t take supplements containing echinacea, evening primrose oil, ginseng or goldenseal without discussing the potential interactions with your pharmacist and physician.
  • CBD Oil: Increasingly used for various health issues, CBD oil may alter the effects of antipsychotics or increase sedation levels.

General Recommendations:

It’s essential for individuals on antipsychotic medication to discuss any vitamin, mineral, or supplement use with their healthcare provider. This is especially important for vitamins and minerals that may be depleted or whose absorption might be affected by long-term medication use. Supplement changes should be made under professional guidance to avoid worsening side effects or reducing the effectiveness of the medication.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Supplements For Anticonvulsant Users

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


Benzodiazepines: How To Avoid Interactions And Nutrient Depletions

Benzodiazepines are a class of medications commonly used to treat anxiety, insomnia, and various other conditions. They work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which has a calming effect on the nervous system. Common benzodiazepines available in the United States include:

  • Diazepam (Brand names: Valium)
  • Lorazepam (Brand names: Ativan)
  • Alprazolam (Brand names: Xanax)
  • Clonazepam (Brand names: Klonopin)
  • Temazepam (Brand names: Restoril)

While benzodiazepines are effective for managing symptoms of anxiety and insomnia, they can interact with other medications and nutrients, leading to potential side effects and nutrient depletions.

Supplement Interaction

  • Kava: Do not combine with supplements containing kava, because these have effects similar your to anti-anxiety medications. Read more in the Supplement-Sciences.com article about Kava.

Drug-Nutrient Interactions and Depletions:

  • Melatonin: Benzodiazepines can interfere with the natural production of melatonin in the body, potentially affecting sleep-wake cycles. Melatonin has been found to improve people’s ability to discontinue benzodiazepine medications. [PMID: 26547856]
  • Vitamin D:  Long-term use of benzodiazepines has been linked to decreased bone density, in part due to potential interference with the metabolism of vitamin D and calcium. [PMC8373308] Vitamin D dosages should be adjusted based on your blood level with many clinicians recommending an optimal Vitamin D level of 50-80 ng/ml. Vitamin D Labs (affiliate link) can be ordered in the NutriScape Lab Shop.
  • B Vitamins: There is some evidence to suggest that chronic use of benzodiazepines may affect the metabolism of certain B vitamins, including vitamin B12 and folate, which are crucial for neurological function and mental health. [PMID: 19409441]

To Sum It Up

Benzodiazepines should be used with caution due to their potential to interact with other medications and affect nutrient levels in the body. Awareness of these interactions is important, especially for those with existing health conditions or those taking multiple medications. Regular monitoring and consultation with healthcare providers are essential to manage these interactions effectively, ensuring the safe and effective use of benzodiazepines. Adopting a holistic approach that considers medication, supplements, and lifestyle factors is key to maintaining optimal health and well-being, underpinned by professional medical advice.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


Table of Contents: Find It Fast

Individual Supplements

Articles Focused on Health Problems

Food First

Fullscript Supplement Plans:

Drug-Nutrient Interaction Supplement Plans

Schisandra

Secure Ordering | Free Shipping | 20% Off Retail Prices

Along with providing information on whether Schisandra supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Schisandra, a berry known for its unique combination of five flavors, has been a staple in traditional Chinese medicine for centuries. Today, it piques the interest of the health-conscious for its array of possible benefits, ranging from liver support to mental clarity. In this article, we delve into the science and tradition behind Schisandra, examining how this ancient berry is finding its place in contemporary wellness practices. Join us as we uncover the multifaceted nature of Schisandra supplements and what current research suggests about their role in supporting overall health and wellbeing.

What Is Schisandra?

Schisandra, scientifically known as Schisandra chinensis, is a plant whose berries are celebrated in traditional medicine, particularly in China and Russia, for their diverse health-promoting properties. This vine, native to the forests of Northern China and parts of Russia, produces small, red berries that are not just nutritional but also a cornerstone of herbal medicine.

Schisandra berries are unique in that they possess all five basic flavors: sweet, salty, bitter, pungent, and sour. This distinctive characteristic is mirrored in their multifaceted health benefits. In traditional Chinese medicine, Schisandra is known as “wu wei zi,” which means “five-flavor fruit,” and it is used to promote balance and harmony within the body’s systems.

The medicinal use of Schisandra spans centuries, with its berries being consumed for their ability to enhance vitality and promote longevity. They are often dried and used in teas, tinctures, and extracts, making them a versatile ingredient in various health supplements.

Schisandra’s health benefits are attributed to its high concentration of lignans, which are phytochemicals that exhibit potent antioxidant and anti-inflammatory properties. These lignans, along with other compounds found in the berries, contribute to the plant’s reputed benefits, which range from supporting liver health to improving mental and physical endurance.

In recent years, Schisandra has gained popularity in the Western world as a dietary supplement, with ongoing research exploring its potential in modern health and wellness applications. As we delve deeper into the benefits of Schisandra supplements, it’s clear that this ancient berry continues to be a valuable asset in the realm of natural health remedies, bridging the gap between traditional wisdom and contemporary science.

What Are the Benefits of Schisandra?

Known for its unique flavor profile and medicinal properties, Schisandra offers a variety of health benefits. Here’s a breakdown of its key advantages:

  • Stress Reduction and Mental Clarity: Schisandra is classified as an adaptogen, meaning it helps the body resist the effects of stress. It’s believed to enhance mental performance and concentration, especially during stressful situations.
    • Mental Health Benefits: It is also known for its potential effects on mood, potentially alleviating symptoms of depression and anxiety.
    • Enhanced Mental Function: Beyond just reducing stress, Schisandra might improve cognitive functions like focus, memory, and alertness.
    • Alzheimer’s: Researchers found that it reduced memory impairment in mice caused by Amyloid beta. [PMC3399599] This effect seems to be related to the gut microbes producing additional short chain fatty acids, which act as neurotransmitters. [PMID: 36731694]
  • Liver Protection: One of the most notable benefits of Schisandra is its hepatoprotective effects. It aids in liver function and is used in treating liver diseases due to its antioxidant properties and ability to promote liver cell regeneration.
  • Immune System Boost: Schisandra contains compounds that help boost the immune system, enhancing the body’s resistance to diseases and infections.
  • Antioxidant Properties: Rich in antioxidants, Schisandra helps combat free radical damage, contributing to overall health and potentially slowing the aging process.
  • Improved Physical Performance: Some studies suggest that Schisandra can increase endurance and physical performance, making it popular among athletes.
  • Respiratory Health: Traditionally, Schisandra has been used to treat respiratory ailments, aiding in breathing and reducing coughs.
  • Cardiovascular Health: Schisandra may benefit heart health by regulating blood pressure and improving circulation.
    • Blood Sugar Regulation: Schisandra may have a role in stabilizing blood sugar levels, which could be beneficial for people with or at risk of diabetes.
    • Cholesterol Management: Early research indicates that Schisandra could help in managing cholesterol levels, thereby contributing to cardiovascular health.
  • Skin Health: Schisandra’s antioxidant and anti-inflammatory properties can contribute to skin health, potentially improving skin vitality and appearance.
  • Anti-Aging Properties: Schisandra is believed to have anti-aging properties, potentially due to its antioxidant content which combats cellular damage from free radicals.
  • Support for Menopausal Symptoms: Some preliminary studies suggest that Schisandra could help alleviate certain menopausal symptoms, such as hot flashes and night sweats.
  • Gastrointestinal Health: There’s some evidence to suggest that Schisandra might help protect the gastrointestinal tract and alleviate symptoms of certain digestive disorders.

Is Schisandra Safe?

Schisandra is generally considered safe for most people when used appropriately. This herb has been used for centuries in traditional Chinese medicine for its various health-promoting properties. Studies have shown that Schisandra is well-tolerated when consumed in moderate amounts. It’s important to note that while adverse effects are rare, they can occur, particularly if taken in high doses or in combination with certain medications.

Medication Interactions with Schisandra

  • Cytochrome P450 2C9 (CYP2C9) substrates: Schisandra can affect the enzyme CYP2C9 in the liver. Medications metabolized by this enzyme may have altered effects or increased side effects.
  • Cytochrome P450 1A2 (CYP1A2) substrates: Similar to CYP2C9 substrates, Schisandra can affect CYP1A2 enzyme activity. This can change how drugs like clozapine, cyclobenzaprine, and fluvoxamine are metabolized.
  • Warfarin (a blood thinner): There is potential for Schisandra to increase the risk of bleeding when taken with warfarin, as it might affect how the body processes the drug.
  • Immunosuppressants: Schisandra might stimulate the immune system and might reduce the effectiveness of medications that decrease the immune system’s activity.
  • Antidiabetic drugs: Schisandra may alter blood sugar levels, which could interfere with the effectiveness of antidiabetic drugs.
  • Barbiturates: Schisandra might increase the breakdown and decrease the effectiveness of barbiturates.

Supplement Interactions with Schisandra

  • St. John’s Wort: This supplement can induce liver enzymes and may affect the metabolism of Schisandra, potentially reducing its effectiveness.
  • Ginkgo Biloba: When taken with Schisandra, there may be an increased risk of bleeding, as both supplements can have blood-thinning effects.
  • Kava: Both Kava and Schisandra can affect the liver. Taking them together might increase the risk of liver damage.
  • Sedative Herbs (such as Valerian, Chamomile, and Hops): Schisandra may enhance the sedative effects of these herbs, potentially leading to excessive drowsiness.
  • Bitter Orange: When combined with Schisandra, there might be an increased risk of high blood pressure and heart rate, as both can stimulate the body.
  • Caffeine and other Stimulants: Schisandra can increase the stimulant effects of caffeine and similar substances, potentially leading to jitteriness, insomnia, or an increased heart rate.
  • Immune-Boosting Supplements (such as Echinacea): Since Schisandra can stimulate the immune system, combining it with other immune-boosting supplements might amplify immune responses.
  • Blood Sugar Modulating Supplements: Schisandra might affect blood sugar levels, so taking it with other supplements that also affect blood sugar could enhance this effect.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Schisandra Online

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Schisandra Extract by Vital Nutrients

 Supports liver function*
• Promotes energy and endurance*
• Provides support during times of stress and fatigue*
• Premium Vegan Formulation

Schisandra has been used for over 2,000 years in Chinese and Japanese practices. It supports liver protective functions due to its lignan content, helps to support liver function, and supports the immune and nervous systems.* Schisandra is considered adaptogenic and provides support during times of stress and fatigue, helping energy, endurance, and stress response.* It may also promote concentration and cognitive performance in times of stress.*  Suggested Use:  Take 2 vegan capsules daily, or as directed by your healthcare professional.

Amount Per 2 veg capsules Serving
Schisandra Extract … 1000mg
(Schisandra chinensis, berry, standardized to 2% total schizandrins)


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Schisandra supplements offer a range of health benefits, making them a notable addition to many wellness routines. Known for their adaptogenic properties, these supplements can help in managing stress and enhancing mental clarity. Schisandra also supports liver function and may improve skin health, thanks to its antioxidant properties. While traditionally used in Chinese medicine, modern research continues to explore and validate these benefits.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


ARB Interactions: Avoid The Salt Substitutes

Angiotensin II Receptor Blockers (ARBs) are a class of drugs commonly used to treat high blood pressure, heart failure, and kidney disease, especially in patients who cannot tolerate ACE inhibitors. Here is a list of ARB medications available in the United States:

  • Losartan (Brand name: Cozaar)
  • Valsartan (Brand name: Diovan)
  • Irbesartan (Brand name: Avapro)
  • Candesartan (Brand name: Atacand)
  • Olmesartan (Brand name: Benicar)
  • Telmisartan (Brand name: Micardis)
  • Eprosartan (Brand name: Teveten)
  • Azilsartan (Brand name: Edarbi)

ARBs work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. By preventing this constriction, ARBs help lower blood pressure and make it easier for the heart to pump blood. As with any medication, ARBs can have side effects and may interact with other drugs, so their use should be managed by a healthcare provider. The choice of a specific ARB depends on individual health conditions and treatment goals.

Drug-Nutrient Interactions:

ARB Drug-Nutrient Interactions:

ARBs include medications such as losartan, valsartan, irbesartan, telmisartan, candesartan, eprosartan, olmesartan, and azilsartan. Angiotensin II Receptor Blockers (ARBs) are used for managing high blood pressure and heart failure, can interact with certain nutrients and dietary supplements. Here are some drug-nutrient or supplement interactions involved with ARBs:

  • Potassium and Potassium SupplementsARB medications can reduce potassium clearance by the kidneys.  This can cause excessive potassium to build up in the blood and can lead to irregular heartbeat when very high levels of potassium are consumed. Don’t use potassium supplements (or electrolyte drinks) without your physician’s approval.  
    • DO NOT USE POTASSIUM-BASED SALT SUBSTITUTES: Many salt substitutes are high in potassium. Since ARBs can raise potassium levels, using these substitutes might further increase the risk of high potassium blood levels. [PMID: 31498767]
  • Vitamin D Supplements: In some cases, vitamin D can increase the blood pressure-lowering effects of ARBs. This interaction isn’t always harmful but should be monitored.
  • St. John’s Wort: This supplement can reduce the effectiveness of many medications, potentially including ARBs, by affecting how the body breaks down the drugs.

Other Interactions to Know

  • Anti-Inflammatory Drugs (NSAIDs): NSAIDs can reduce the effectiveness of ARBs and increase the risk of kidney problems. This includes over-the-counter medications like ibuprofen and naproxen.
  • Alcohol: While not a nutrient or supplement, alcohol can augment the blood pressure-lowering effects of ARBs, potentially leading to hypotension (low blood pressure).
  • Antacids: Some antacids, especially those containing aluminum or magnesium, can affect the absorption of ARBs when taken simultaneously.

ACE Inhibitor Interactions: Zinc Depletion Is An Issue

The following is a list of the ACE inhibitors that are available in the US:

  • benazepril (Lotensin)
  • captopril (Capoten- discontinued brand)
  • enalapril (Vasotec, Epaned, [Lexxel- discontinued brand])
  • fosinopril (Monopril- Discontinued brand)
  • lisinopril (Prinivil, Zestril, Qbrelis)
  • moexipril (Univasc- Discontinued brand)
  • perindopril (Aceon)
  • quinapril (Accupril)
  • ramipril (Altace)
  • trandolapril (Mavik)

Drug-Induced Nutrient Depletions

  • ZincACE inhibitors deplete zinc. [PMC5874849] If you take any of the ACE inhibitors, your multivitamin should include 11mg of Zinc. [PMID: 16819574]

Interactions

  • Potassium: DO NOT USE POTASSIUM-BASED SALT SUBSTITUTES. ACE inhibitors can reduce potassium clearance by the kidneys.  This can cause excessive potassium to build up in the blood and can lead to irregular heartbeat when very high levels of potassium are consumed. Don’t use potassium supplements (or electrolyte drinks) without your physician’s approval.  
  • CoQ10 and Fish Oil can reduce blood pressure. If you are taking blood pressure medicines, be careful to monitor blood pressure when adding CoQ10 or Fish Oil.
  • Garlic, Ginkgo

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order Supplements To Replace Zinc

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

O.N.E. Multivitamin — Pure Encapsulations

Serving Size: 1 capsule / Dose: 1 per day

Amount Per Serving
Vitamin A … 1,125mcg (as vitamin A acetate and 73% beta carotene)
Vitamin C … 180mg (as ascorbic acid)
Vitamin D … 50mcg (as cholecalciferol) (D3) (2,000 IU)
Vitamin E … 20mg (as d-alpha tocopherol succinate)
Thiamin … 3mg (as thiamin HCl) (B1)
Riboflavin … 3mg (as vitamin B2 and 43% riboflavin 5′ phosphate (activated B2))
Niacin … 20mg (as niacinamide)
Vitamin B6 … 4mg (as pyridoxine HCl and 38% pyridoxal 5′ phosphate (activated B6))
Folate … 667mcg DFE (as Metafolin®, L-5-MTHF) (L-5-MTHF 400 mcg)
Vitamin B12 … 500mcg (as methylcobalamin)
Biotin … 300mcg
Pantothenic acid … 10mg (as calcium pantothenate) (B5)
Iodine … 150mcg (as potassium iodide)
Zinc … 25mg (as zinc citrate)
Selenium … 70mcg (as selenomethionine)
Manganese … 2mg (as manganese citrate)
Chromium … 200mcg (as chromium polynicotinate)
Molybdenum … 75mcg (as TRAACS™ molybdenum glycinate chelate)
Boron … 1mg (as boron glycinate)
Choline … 10mg (as choline bitartrate)
Inositol … 25mg
Coenzyme Q10 sustained-release … 50mg (as CoQ10 and as 18% from MicroActive® CoQ10-cyclodextrin complex)
Alpha lipoic acid … 50mg
FloraGLO® lutein … 3mg
Zeaxanthin … 500mcg
Lycopene … 500mcg

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


Oral Contraceptives: Depression Causing Nutrient Depletions, Plus The Herbals That Can Make Them Fail

Oral contraceptives cause key nutrient depletions concern folic acid, vitamins B2, B6, B12, vitamin C and E and the minerals magnesium, selenium and zinc. [PMID: 23852908]

These nutrients can be replaced by a quality multivitamin/mineral supplement along with magnesium and healthy eating.

  • Folate: “Because of the reduction in blood folate concentrations associated with the use of oral contraceptives, it is critical for women of childbearing age to continue folate supplementation during oral contraceptive use.” [PMC1862844],
  • Vitamin B6: Vitamin B6 supplementation reduces symptoms of depression in women using oral contraceptives. [PMID: 35109763]
  • Vitamin C: Plasma levels of Vitamin C are lower in women who take oral contraceptives.
  • Magnesium: Magnesium levels are lower in women taking oral contraceptives, although researchers are not sure if they should recommend magnesium supplements to all users based on this fact alone. However, population studies estimate that about 60% of adults do not achieve the acceptable dietary intake (ADI) and 45% of Americans are magnesium deficient. [PMC6163803]

Herbal Supplement Interactions

Caffeine Clearance

  • Caffeine: Oral contraceptives might decrease caffeine clearance by 40% [PMID: 7022590], so you might find you have problems with green tea or coffee intake because of the caffeine.

Boron: Essential In Arthritis, Bone Health, and Cutting Cancer Risk

Secure Ordering | Free Shipping | 20% Off Retail Prices

Along with providing information on whether boron supplements might be right for you, this article also links to Fullscript where you can buy boron supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Boron is trace mineral that plays a vital role in various physiological processes from strengthening bones to regulating hormones. This article explores the multifaceted benefits of boron, highlighting how this lesser-known nutrient impacts bone health, hormonal balance, and more. As we delve into the science behind boron’s effectiveness, the importance of incorporating this mineral into your diet becomes clear, marking a simple yet powerful step towards better health.

What Is Boron?

Boron is a naturally occurring trace mineral that plays a vital role in the health and functioning of the human body, despite being needed in only small amounts. It’s not as widely discussed as minerals like calcium or iron, but it’s just as important. Found in the environment and certain foods, boron is essential for the growth and maintenance of bone, aiding in the absorption of calcium and magnesium, and potentially influencing hormones like testosterone and estrogen. In addition to its role in bone health, boron is believed to impact brain function, including cognitive performance, and has anti-inflammatory and antioxidant properties. This makes it valuable not just for physical health but also for cognitive wellness. Although the body requires only small amounts of boron, its impact on overall health is significant, particularly in areas like bone strength, hormonal balance, and cognitive abilities.

What Are The Health Benefits of Boron?

  • Bone Health: Boron is vital for the growth and maintenance of strong bones. It enhances the body’s ability to utilize and absorb calcium, magnesium, and vitamin D, which are the cornerstones of bone health. This not only aids in the development of robust bone structure but also helps in maintaining bone density and preventing bone diseases such as osteoporosis. The presence of adequate boron levels ensures that the body can effectively use these key minerals, making it a critical component in bone health management. [PMID: 32540741]
  • Arthritis (Anti-Inflammatory Properties): Boron exhibits notable anti-inflammatory properties, making it beneficial for those suffering from conditions like arthritis. By reducing inflammation, boron can help alleviate joint pain and discomfort, contributing to improved joint mobility and overall joint health. This anti-inflammatory action is not only important for joint health but also for reducing pain and discomfort associated with various inflammatory conditions. [PMC8732765, PMC8732765]
  • Immune System Support: Boron plays a significant role in supporting the immune system, likely due to its combined anti-inflammatory and antioxidant properties. These properties help modulate the immune response, potentially enhancing the body’s ability to fight off infections and diseases. [PMC4774930]
  • Heart Health: Boron has the potential to reduce risk factors associated with cardiovascular diseases. While the specific mechanisms are still being researched, boron’s influence on factors such as inflammation and mineral metabolism might contribute to better heart health. However, more research is needed to fully understand and validate these effects. [PMC7553911]
  • Reduced Risk of Certain Cancers: Boron is suggested to lower the risk of certain types of cancers, particularly those influenced by hormonal imbalances, such as prostate and cervical cancer. This is believed to be due to boron’s role in regulating hormones and maintaining cellular health, which can be crucial in cancer prevention. [PMID: 19912103]
  • Hormonal Balance: Boron has a significant impact on the levels of key hormones like estrogen and testosterone. By modulating these hormones, boron plays a role in various aspects of health including sexual health, reproductive function, and the maintenance of lean muscle mass. In women, it can influence estrogen levels, which is particularly important for bone density and overall hormonal balance. In men, boron’s effect on testosterone levels can affect muscle strength and bone density, making it an important mineral for overall vitality. [PMC4712861]
  • Antioxidant Protection: As an antioxidant, boron plays a role in protecting cells from the damage caused by oxidative stress. Oxidative stress is a factor in many chronic diseases, including heart disease and some cancers. Boron’s antioxidant properties mean it can help neutralize free radicals, which are harmful molecules that can damage cells. This protective role is essential for maintaining cellular health and preventing the development of chronic diseases.
  • Mineral Metabolism: Boron assists in the metabolism of crucial minerals like calcium, magnesium, and phosphorus. These minerals are essential for numerous bodily functions, including bone health, nerve function, and muscle contraction. Boron’s role in mineral metabolism ensures that these minerals are used effectively in the body.
  • Wound Healing: Topically applied boron aids in the wound healing process, primarily through its anti-inflammatory effects, which can reduce swelling and pain at injury sites. This leads to faster recovery and more efficient healing, as inflammation is a critical factor in the body’s response to injury. [PMC4712861]
  • Cell Membrane Function: Boron supports the health and function of cell membranes, which are crucial for maintaining cell integrity, facilitating efficient communication between cells, and ensuring the proper functioning of cells. Healthy cell membranes contribute to the overall vitality and resilience of cells, playing a key role in numerous biological processes.

“Boron has been proven to be an important trace mineral because it:

  • is essential for the growth and maintenance of bone;
  • greatly improves wound healing;
  • beneficially impacts the body’s use of estrogen, testosterone, and vitamin D;
  • boosts magnesium absorption;
  • reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α);
  • raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase;
  • protects against pesticide-induced oxidative stress and heavy-metal toxicity;
  • improves the brains electrical activity, cognitive performance, and short-term memory for elders;
  • influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+));
  • has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin’s lymphoma; and
  • may help ameliorate the adverse effects of traditional chemotherapeutic agents.
Nothing Boring About Boron [PMC4712861]

How Much Boron Is Needed?

So far, research on boron, a mineral, shows that its health benefits are most noticeable when you take up to 3 milligrams per day. There aren’t any specific recommended daily amounts for boron, but experts suggest not taking more than 20 milligrams per day for adults. Studies haven’t found any risks associated with boron at low doses and there’s a lot of evidence that it can be beneficial.

Because of this, taking a boron supplement of 3 milligrams each day might be a good idea, especially for people who don’t eat many fruits and vegetables, or those who are dealing with or at risk of bone conditions like osteopenia and osteoporosis, joint issues like osteoarthritis, or certain types of cancer like breast, prostate, or lung cancer.

Food Sources of Boron

Food SourceTypical PortionBoron Content (Approx.)
Avocado1 medium avocado1.07 mg
Raisins1/4 cup (40 grams)0.88 mg
Almonds1 ounce (28 grams)0.79 mg
Hazelnuts1 ounce (28 grams)0.77 mg
Dried Apricots1/4 cup (35 grams)0.74 mg
Peanut Butter2 tablespoons (32 grams)0.61 mg
Red Kidney Beans1 cup cooked (177 grams)2.48 mg
Bananas1 medium banana0.43 mg
Prunes1/4 cup (44 grams)0.52 mg
Potatoes1 medium potato0.35 mg
Wine5 ounces (147 grams)1.26 mg (Note: Consume in moderation)
Coffee8 ounces (237 ml)0.17 mg

Are Boron Supplements Safe?

Boron supplements, especially in low doses, are generally considered safe for most people. At a low dose of 3-6 mg per day, boron is generally considered safe and does not typically have significant interactions with most medications or dietary supplements. It’s important to note that these potential interactions are generally not a concern at low doses like mg per day.

Boron Supplement Interactions with Medications

  • Hormone-related Medications: Boron can affect the levels of certain hormones in the body, including estrogen and testosterone. Therefore, it might interact with hormone therapies or contraceptives.
  • Anti-inflammatory Medications: While not a direct interaction, boron has anti-inflammatory properties that may complement the effects of certain anti-inflammatory drugs.

Boron Interactions with Other Supplements

  • Magnesium Supplements: Since boron affects the way the body handles other minerals, it can potentially influence magnesium absorption or metabolism.
  • Calcium and Vitamin D Supplements: Similar to magnesium, boron may impact the metabolism or effectiveness of calcium and vitamin D supplements.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

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Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Boron – 3 mg by Seeking Health

Boron by Seeking Health provides 3 mg of boron per vegetarian capsule in a well-tolerated glycine complex form. Boron may play a regulatory role in the metabolism of minerals, including magnesium and phosphorous, and certain vitamins, such as vitamin D. Boron may help support normal estrogen metabolism. Dietary boron is found in most water sources, and as a trace element in avocados, peanuts, prune juice and grape products including juice, wine and raisins. While the precise function of boron in humans is not well understood, the micromineral is thought to have some implications for estrogen metabolism, healthy bones, and cognitive health.

Suggested Use:

Take 1 capsule with food or as directed by your healthcare professional.

Warnings:

Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 120

Boron (as Albion® Bororganic glycine) 3 mg


Liquid Ionic Boron 6mg by Trace Minerals Research

Liquid Ionic Boron is a rich concentrated liquid dietary supplement that provides boron, a trace element, in ionic form – the form most widely recognized by the body†. Our proprietary process ensures maximum absorption, while the balanced liquid form provides safety and flexibility. Boron may support healthy bones and joints†. Recent clinical studies indicate that boron interacts with calcium and magnesium to promote optimal bone metabolism†. Evidence also suggests boron may support normal brain function. 48-day supply, 6 mg/serving of a Boron Complex.

Using the pre-measured dropper, take 1.25 mL (¼ teaspoon) daily. 

Serving Size: 1.25 mL (1/4 tsp.)

Amount Per Serving
Boron … 6mg (ConcenTrace®)
Magnesium … 25mg (ConcenTrace®)
Chloride … 70mg (ConcenTrace®)
Sulfate … 5.5mg (FeSO4 (ConcenTrace®)


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

To Sum It Up

Boron supplementation offers a range of benefits that extend across various aspects of health and wellness. As a trace mineral, boron plays a pivotal role in bone health, hormonal balance, and cognitive function. Its supplementation can particularly benefit people seeking to improve bone density, reduce symptoms of arthritis, and combat mental decline. Then there is boron’s influence on hormone regulation, especially estrogen and testosterone, which makes it valuable for those looking to optimize their hormonal health. While boron is available in common dietary sources, supplementation ensures adequate intake, especially for those whose diets might lack in boron-rich foods.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


Spike: Discover Supplements That Help Degrade the Covid-19 Spike Protein

First, it’s important to fully acknowledge that there is no scientifically proven dietary supplement officially recognized for degrading or blocking the spike protein of viruses like SARS-CoV-2, the virus responsible for COVID-19. However, there are some studies of nutritional supplements showing that the spike protein from vaccines and Covid infections persist after Covid infection or vaccination and that they can be broken down with certain dietary supplements. The “McCullough Protocol” combines 3 supplements that have been shown to affect the spike protein.

It’s crucial to rely on evidence-based treatments and preventive measures for viral infections and consult healthcare professionals for advice on supplements and their effects on viral diseases. However, given the general lack of consensus, research data, and the absence of known harm from the proposed nutritional supplements, it seems reasonable to entertain the potential benefit of supplements on the basis of published theory alone. This article briefly discusses an emerging theory.

In addition, this article provides easy access to buy the McCullough Protocol supplements online through the secure Fullscript professional-grade online formulary at 20% off retail with free shipping.

The Problem With Spikes

Emerging research suggests that the SARS-CoV-2 spike protein might contribute to health problems, including cardiovascular and blood clotting injuries, after either COVID-19 infection or vaccination. [PMC9428332] Long-term detection of the spike protein in people with either “long-covid” or vaccine injury suggests it might have a role in prolonged symptoms. [PMC10452662]

Consequently, researchers have proposed a detoxification protocol targeting the spike protein. It features supplements including nattokinase, bromelain, and curcumin. Some researchers believe that this strategy might be used to help people with post-infection and post-vaccination complications. [PMC10663976] [McCullough, 2023]

A: Dissolution of spike protein-induced thrombus. Nattokinase directly degrades fibrinolysis-resistant fibrin (from spike protein), and bromelain upregulates fibrinolysis. B: Inhibition of spike protein via ACE2 receptors. Bromelain and curcumin block the ACE2 receptor, preventing spike protein from binding. C: Proteolytic degradation of spike protein. Nattokinase and bromelain degrade spike proteins, rendering them inactive. D: Attenuation of spike protein-induced inflammation. Bromelain and curcumin downregulate the NF-kB signaling pathway induced by spike protein, leading to the suppression of inflammatory molecules. E: BSD treatment protocol. The full treatment regimen and the addition of other compounds based on clinical indication are illustrated. Abbreviations: TPA = tissue plasminogen activator, PAI-1 = plasminogen activator inhibitor-1, ACE2 = angiotensin converting enzyme-2, NF-kB = nuclear factor kappa B, S1/S2 = spike protein subunits S1/S2, TLR4 = toll-like receptor 4.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

Order McCullough Protocol Supplements

Why Professionals Choose the Fullscript Formulary

Your health is on the line. Health professionals know that many other online and retail options set a very low bar for quality–sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Health professionals trust Fullscript to continuously monitor the quality of each item on the platform. Other retailers operate with profit as their highest or only motive when choosing brands. Fullscript cares only about quality and reliability. Unlike discount stores, large online marketplaces, and other retailers you won’t find ingredients sourced from China or other questionable locations or companies.
  • Always 20% Discount off the manufacturer’s retail price. When you follow any link from Supplement-Sciences.com, you will automatically get 20% off the retail price.
  • Free shipping over $50.
  • Freshness. Fullscript prioritizes freshness over bulk buying even if it means an increased risk of briefly being out of stock.
  • Top quality phone and online support. When you call, knowledgeable humans at Fullscript answer your questions.
  • How It Works:
    • Easy Sign-up & No Spam Email: Click the “View Product” button below to be taken to Fullscript’s login page where you can quickly create your secure account with just your name, email, and phone number. Then you will be taken directly to the product page.
    • Wide variety of supplement options: Once you sign in to your account, you are not limited to the products listed below. You will see similar items listed at the bottom of each product page on Fullscript.
    • Search For What You Want: Once inside Fullscript, you can search for the exact brands and products you want from their wide selection of quality brands.

Order Nattokinase Supplements

The McCullough Protocol recommends a dose of 2000 FU nattokinase twice per day to break down blood clots.

Nattokinase by Ortho Molecular Products (60 count)

Nattokinase is a powerful enzyme used to support normal blood flow, circulation, and maintain normal ranged blood pressure levels.
1 soft gel capsule, one or two times per day or as recommended by your health care professional.

Amount Per 1 Softgel Serving
Nattokinase … 100 mg (2,000 Fibrinolytic Units)

Order Bromelain Supplements

The McCullough Protocol recommends a bromelain dose of 500 mg once per day to break down proteins, and reduce inflammation and blood clotting.

Bromelain 2400 GDU by Vital Nutrients

Bromelain is an enzyme found in pineapple stem, with a long history of use as a dietary supplement. Bromelain is considered a proteolytic enzyme due to its ability to break down protein when taken with food, although its benefits extend beyond digestion. When taken between meals, Bromelain helps support the body’s physiologic levels of kinins and fibrins, promoting healthy capillary blood flow to facilitate delivery of nutrients and removal of inflammatory waste products.* Bromelain is particularly useful for individuals interested in promoting normal sinus, tissue, and musculoskeletal health.*


Suggested Use: Take 1 capsule before each meal or as directed by your healthcare professional.

Serving Size: 1 Vegetarian Capsule

Amount Per Serving
Bromelain … 375mg
(2400GDU/g)

Other Ingredients: Vegetable Cellulose Capsule, Rice Powder, and Ascorbyl Palmitate.

Order Curcumin Supplements

The McCullough Protocol recommends 500 mg curcumin twice per day as an antiviral, anti-inflammatory and anti-fibrotic.

Curcumin 95 500mg by Jarrow Formulas

Provides Antioxidant Support*

  • Protects From Oxidative Damage*
  • 95% Active Curcuminoids
  • Quality & Value

Curcumin 95 is a concentrate of 95% curcuminoids, which are powerful antioxidants found in the spice turmeric. Specifically, curcumin and its derivatives help support antioxidant status and help minimize oxidative stress.*

Take 1 capsule per day with food or as directed by your qualified healthcare professional. 

Serving Size: 1 Capsule

Amount Per Serving
Turmeric Concentrate … 500mg
(Curcumin C33 Complex®)(Curcuma longa)(95% Total Curcuminoids)(Rhizome)

Research On The Possible Benefit of Green Tea (EGCG)

Although it is not part of the McCullough Protocol, there is some research having to do with other natural compounds inhibiting the binding of spike protein. A study explored the potential of epigallocatechin gallate (EGCG) from green tea to block the fusion of the COVID-19 virus spike protein with human cells. EGCG showed promise in blocking the interaction between the virus’s spike protein and the human cell receptor, possibly reducing infection and replication of the virus in cells. This finding highlights EGCG as a possible inhibitor of COVID-19 entry into cells. [PMC9278780] [PMID: 34375189] [PMC8290267]

Epigallocatechin gallate (EGCG) works by hindering the virus’s ability to attach to cell surfaces, specifically targeting the interaction with heparan sulfate proteoglycans, which are key for the virus’s entry into cells. This property of EGCG suggests its potential as a broad-spectrum agent against various coronavirus strains, including SARS-CoV-2 variants, by blocking their initial attachment to cells. [PMC9330937]

Order EGCG

EGCg 400mg by Protocol for Life Balance

One capsule of Protocol For Life Balance™ EGCg, 200 mg, possesses the phytonutrient content equal to about 2-3 cups of green tea.

Amount Per 1 Capsule Serving
Green Tea Extract … 200 mg (Camellia sinensis) (Leaf)
(Standardized Extract) [80% Total Catechins, and 50% EGCg (Epigallocatechin Gallate) (200 mg)](up to 4 mg of naturally occurring caffeine)
Decaffeinated Green Tea … 50mg (Camellia sinensis) (Leaf)

Research On The Benefit of Black Seed

Black Seed (Nigella sativa) is a natural food supplement that provides many documented antiviral compounds. [PMC7445151] Researchers report that molecular docking studies have shown that thymoquinone (a component of black seed) could block the COVID-19 virus by binding to the receptor-binding domain on the spike and envelope proteins of SARS-CoV-2. This may stop the virus entry into the cell and stop infection. [PMC8106451]

Black seed may also reduce the symptoms of Covid. A study found that 500 mg black seed oil supplementation was associated with faster recovery of Covid symptoms than usual care alone for patients with mild COVID-19 infection. [PMID: 36825730]

Black Seed Oil

Amount Per 1 Teaspoon Serving
Calories
 … 35
Calories from Fat … 35
Total Fat … 4g
Saturated Fat … 1g
Organic Black Cumin Seed Oil … 4.6g
(Nigella Sativa)


Suggested Use (Capsules):
Take two (2) capsules 1 to 2 times daily with food or as directed by a healthcare professional.


Serving size: 2 Capsules

Amount Per Serving
Calories
 … 10
Calories from Fat … 10
Total Fat … 1.5g
Black Cumin Seed Oil … 1300mg
(Nigella Sativa) [Supplying Thymoquinone (TQ)]

To Sum It Up

Recent studies suggest the spike protein of SARS-CoV-2, associated with COVID-19 infections as well as Covid vaccines, may lead to cardiovascular and blood clotting problems. The spike protein has been detected long after infection or vaccination, indicating a possible link to prolonged symptoms some people experience. As a response, a detoxification approach using nattokinase, bromelain, and curcumin is being considered. The McCullough protocol aims to target and break down the spike protein, potentially forming a vital part of treatment strategies for ongoing post-COVID-19 and vaccine-related complications. EGCg also has the potential to keep the spike protein from binding, thereby possibly helping reduce the risk of infection with a wide array of Covid subvariants.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.


Pain Relief Naturally: Exploring Devil’s Claw’s Anti-Inflammatory Benefits

Secure Ordering | Free Shipping | 20% Off Retail Prices

Along with providing information on whether Devil’s Claw’s supplements might be right for you, this article also links to Fullscript where you can buy supplements online through Fullscript’s secure healthcare formulary and get free shipping and 20% off the retail price of professional-grade supplements.

Devil’s Claw, a herb native to Africa, has sparked interest for its role in nutrition and wellness circles. Named for the claw-like shape of its fruit, this plant has been traditionally used to address a variety of health concerns. Today, nutritional supplements harnessing Devil’s Claw are valued for their possible benefits, which include soothing joint pain and reducing inflammation.

And Devil’s Claw supplements are right for you, this article will show you the best place to buy Devil’s Claw online. This article describes the properties of Devil’s Claw, exploring the scientific backing behind their use and how they might contribute to a holistic approach to health.

What Is Devil’s Claw?

“Devil’s Claw, scientifically known as Harpagophytum procumbens, is an herbal remedy with a rich history in traditional medicine. Native to the arid regions of southern Africa, this plant has been valued for generations for its potential health benefits. The name ‘Devil’s Claw’ comes from the small, hook-like projections on its fruit. In traditional medicine, Devil’s Claw has been appreciated for its anti-inflammatory properties, making it a natural choice for addressing conditions related to joint discomfort and rheumatism. Let’s explore Devil’s Claw and its potential advantages for health and wellness.”

Devil’s Claw

What Are the Benefits of Devil’s Claw?

  • Natural Pain Relief: Devil’s Claw is known for its analgesic (pain-relieving) properties and is often used to alleviate various types of pain, including joint pain, arthritis, and muscle discomfort. [PMID: 17212570]
  • Anti-Inflammatory: It has anti-inflammatory effects, which can help reduce inflammation associated with conditions like osteoarthritis and rheumatoid arthritis. [PMC9182060]
  • Anti-Rheumatic Properties: It is often used in traditional herbal medicine to address rheumatic conditions, including rheumatoid arthritis. [PMID: 17886223]
  • Improved Mobility: Regular use of Devil’s Claw may enhance joint mobility and flexibility, making it easier for individuals with joint conditions to move comfortably. [PMID: 17128436]
  • Antioxidant Properties: It contains compounds with antioxidant properties, which can help protect cells from oxidative stress and damage. [PMC9182060]
  • Potential Weight Management: Some animal research suggests that Devil’s Claw may aid in weight management by acting on ghrelin receptors to reduce hunger and promote a feeling of fullness. [PMC4113378]
  • Traditional Medicine:
    • Pain and Fever: It has a history of use in traditional African medicine for various ailments, including pain and fever relief.
    • Headache Relief: Some people find relief from tension headaches and migraines when using Devil’s Claw supplements.
    • Skin Conditions: Topical application of Devil’s Claw extracts may assist in managing certain skin conditions. [PMID: 17128436]
    • Digestive Aid: Devil’s Claw has been traditionally used to support digestive health, helping with issues like indigestion and upset stomach. [PMID: 31273865]

Arthritis and other rheumatic conditions (AORC) are the leading cause of disability, are associated with poor quality of life and incur considerable direct and indirect costs…. There were statistically significant (p < 0.0001) improvements in patient assessment of global pain, stiffness and function. There were also statistically significant reductions in mean pain scores for hand, wrist, elbow, shoulder, hip, knee and back pain…. and 60% patients either reduced or stopped concomitant pain medication. Harpagophytum is an effective and well-tolerated serious treatment option for mild to moderate degenerative rheumatic disorders providing improved quality of life measure.

Effectiveness and safety of Devil’s Claw tablets in patients with general rheumatic disorders [PMID: 17886223]

Is Devil’s Claw Safe?

Devil’s Claw, known for its potential health benefits, is generally considered safe for many individuals when used as directed. It has a long history of traditional use, primarily in African and European herbal medicine, with relatively few reported adverse effects. Additionally, numerous studies and clinical trials have not raised significant safety concerns when Devil’s Claw supplements are consumed within recommended dosages. However, as with any herbal supplement or remedy, individual responses can vary, and some people may experience mild gastrointestinal discomfort or allergic reactions.

Medication Interactions with Devil’s Claw

  • Anticoagulants (Blood Thinners): Devil’s Claw may increase the risk of bleeding when taken with anticoagulant medications, potentially leading to excessive bleeding or bruising.
  • Antiplatelet Drugs: Similar to anticoagulants, Devil’s Claw may enhance the effects of antiplatelet drugs, increasing the risk of bleeding.
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Devil’s Claw has anti-inflammatory properties, and when combined with NSAIDs, it may enhance the anti-inflammatory effects. However, this interaction could potentially increase the risk of gastrointestinal irritation and bleeding.
  • Acetaminophen (Paracetamol): Devil’s Claw may have additive analgesic (pain-relieving) effects when used with acetaminophen. This interaction might lead to more potent pain relief.
  • Antihypertensive Medications: Devil’s Claw could potentially lower blood pressure. When taken with antihypertensive medications, it may enhance their blood pressure-lowering effects, possibly causing excessively low blood pressure.
  • Diabetes Medications: Devil’s Claw may influence blood sugar levels. When combined with diabetes medications, it may lead to hypoglycemia (low blood sugar). Monitoring blood sugar levels is essential in such cases.
  • Lithium: Devil’s Claw may reduce the excretion of lithium from the body, potentially leading to increased lithium levels and an increased risk of lithium toxicity.

Supplement Interactions with Devil’s Claw

  • Blood-Thinning Supplements (e.g., Fish Oil, Ginkgo Biloba): Devil’s Claw may have mild blood-thinning properties. When taken with supplements that also have blood-thinning effects, such as fish oil or ginkgo biloba, there is a potential risk of increased bleeding or bruising.
  • Anti-Inflammatory Supplements (e.g., Turmeric, Bromelain): Devil’s Claw possesses anti-inflammatory properties. When combined with other anti-inflammatory supplements like turmeric or bromelain, it may enhance the overall anti-inflammatory effects. However, this interaction could potentially increase the risk of gastrointestinal irritation or bleeding.
  • Supplements with Hypotensive Effects (e.g., Garlic, Hawthorn): Devil’s Claw may have a mild hypotensive (blood pressure-lowering) effect. When used alongside supplements with similar effects, such as garlic or hawthorn, it may lead to excessively low blood pressure.
  • Glucose-Lowering Supplements (e.g., Berberine, Cinnamon): Devil’s Claw may influence blood sugar levels. When combined with glucose-lowering supplements like berberine or cinnamon, it could potentially lead to hypoglycemia (low blood sugar). Monitoring blood sugar levels is essential in such cases.
  • Supplements with Potential Diuretic Effects (e.g., Dandelion Root, Green Tea Extract): Devil’s Claw may have mild diuretic properties. When taken with supplements that also have diuretic effects, such as dandelion root or green tea extract, it may lead to increased urine production and potential dehydration if not managed properly.

When you purchase linked products presented on this page, Supplement Sciences, LLC receives affiliate fees so that our dietitians can continue to create great content.

Thank you for your support!

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Why Professionals Choose the Fullscript Formulary

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Devil’s Claw Secondary Root by Nature’s Way

Devil’s Claw Secondary Root

Devil’s Claw is a traditional African medicine.

Suggested Use: Take 2 capsules twice daily. If pregnant, nursing or taking any medications, consult a healthcare professional before use.

Serving Size: 2 Veg Capsules

Devil’s Claw 960 mg (tuber)

Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.

“To Sum It Up”

Based on traditional medicinal practices and preliminary animal research, Devil’s Claw supplements appear to offer potential health advantages. These potential benefits encompass enhanced joint health, reduced inflammation, and anti-rheumatic properties. These positive effects can be traced back to Devil’s Claw’s bioactive compounds and its longstanding use in herbal medicine traditions.


This Article is Not a Substitute for Medical Advice

Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. The Supplement Sciences website seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take. People taking medications for the treatment of HIV or with a history of organ transplant must not take supplements without consulting with their physician.