ACE Inhibitor Interactions: Zinc Depletion Is An Issue

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Along with providing information on whether Zinc supplements might be right for you, this article also links to Fullscript where you can buy high quality supplements. Order online through Fullscript’s secure healthcare formulary to get the best prices and free shipping on professional-grade supplements.

The following is a list of the ACE inhibitors that are available in the US:

  • benazepril (Lotensin)
  • captopril (Capoten- discontinued brand)
  • enalapril (Vasotec, Epaned, [Lexxel- discontinued brand])
  • fosinopril (Monopril- Discontinued brand)
  • lisinopril (Prinivil, Zestril, Qbrelis)
  • moexipril (Univasc- Discontinued brand)
  • perindopril (Aceon)
  • quinapril (Accupril)
  • ramipril (Altace)
  • trandolapril (Mavik)

Drug-Induced Nutrient Depletions

  • ZincACE inhibitors deplete zinc. [PMC5874849] If you take any of the ACE inhibitors, your multivitamin should include 11mg of Zinc. [PMID: 16819574]

Interactions

  • Potassium: DO NOT USE POTASSIUM-BASED SALT SUBSTITUTES. ACE inhibitors can reduce potassium clearance by the kidneys.  This can cause excessive potassium to build up in the blood and can lead to irregular heartbeat when very high levels of potassium are consumed. Don’t use potassium supplements (or electrolyte drinks) without your physician’s approval.  
  • CoQ10 and Fish Oil can reduce blood pressure. If you are taking blood pressure medicines, be careful to monitor blood pressure when adding CoQ10 or Fish Oil.
  • Garlic and Ginkgo: These herbs may affect blood clotting. It is a good idea to talk to a healthcare provider if you take them with medications that affect bleeding.

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Order Supplements To Replace Zinc

Why Professionals Choose the Fullscript Formulary

Health professionals know that many online and retail options set a very low bar for quality– sometimes amazingly low. The Fullscript formulary is the most secure online source for the highest quality brands, securely sourced to assure freshness and purity. Here’s what makes Fullscript the best:

  • Meticulous vetting of brand quality. Meticulous vetting of brand quality. Health professionals trust Fullscript to monitor the quality of every item. While other retailers prioritize profit above all else, Fullscript focuses solely on quality and reliability. Unlike discount stores and large online marketplaces, you won’t find ingredients sourced from China or other questionable suppliers.
  • Free shipping over $50 and best prices when you order through Supplement Sciences.
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O.N.E. Multivitamin — Pure Encapsulations

Serving Size: 1 capsule / Dose: 1 per day

Amount Per Serving
Vitamin A … 1,125mcg (as vitamin A acetate and 73% beta carotene)
Vitamin C … 180mg (as ascorbic acid)
Vitamin D … 50mcg (as cholecalciferol) (D3) (2,000 IU)
Vitamin E … 20mg (as d-alpha tocopherol succinate)
Thiamin … 3mg (as thiamin HCl) (B1)
Riboflavin … 3mg (as vitamin B2 and 43% riboflavin 5′ phosphate (activated B2))
Niacin … 20mg (as niacinamide)
Vitamin B6 … 4mg (as pyridoxine HCl and 38% pyridoxal 5′ phosphate (activated B6))
Folate … 667mcg DFE (as Metafolin®, L-5-MTHF) (L-5-MTHF 400 mcg)
Vitamin B12 … 500mcg (as methylcobalamin)
Biotin … 300mcg
Pantothenic acid … 10mg (as calcium pantothenate) (B5)
Iodine … 150mcg (as potassium iodide)
Zinc … 25mg (as zinc citrate)
Selenium … 70mcg (as selenomethionine)
Manganese … 2mg (as manganese citrate)
Chromium … 200mcg (as chromium polynicotinate)
Molybdenum … 75mcg (as TRAACS™ molybdenum glycinate chelate)
Boron … 1mg (as boron glycinate)
Choline … 10mg (as choline bitartrate)
Inositol … 25mg
Coenzyme Q10 sustained-release … 50mg (as CoQ10 and as 18% from MicroActive® CoQ10-cyclodextrin complex)
Alpha lipoic acid … 50mg
FloraGLO® lutein … 3mg
Zeaxanthin … 500mcg
Lycopene … 500mcg


Food First!

Although this article discusses supplements in detail, don’t forget that we are absolutely committed to the “Food First” approach to nutrition. When it comes to your health, the totality of your eating habits far surpasses the impact of individual nutrients or any single supplement you consume. Even though this article doesn’t delve into the broader picture of your overall diet, it’s crucial to keep this element at the forefront of our minds. Food is one of the “Pillars of Health”. Your food needs to provide all the vitamins, minerals, fiber, and phytochemicals to nourish your body systems down to the cellular level.

Food choices, rather than supplements, are the most critical factors for a healthy gut microbiome. These trillions of tiny inhabitants in your gut affect your brain waves; they orchestrate your immune system. They possess the power to create molecules that can switch genes on or off and are even capable of synthesizing neurotransmitters. Opting for organic foods and steering clear of plastic packaging (including those labeled BPA-free) is a smart move to limit toxin exposure. The sum of all these parts leads to a powerful conclusion: the ultimate key to your health lies in the quality and balance of the food you consume. Supplements are secondary.


This Article is Not a Substitute for Medical Advice

This information is provided for educational purposes only and is not a substitute for medical advice. Supplement Sciences does not provide medical care and cannot ensure the safety or effectiveness of any product for your personal use. Always consult your physician before starting any supplement, especially if you are pregnant, breastfeeding, or managing a serious health condition such as cancer, liver disease, or kidney disease. Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease.


* These statements have not been evaluated by the Food and Drug Administration.

About the Author

Stephanie Figon, MS, RDN, LD

Creator of Supplement Sciences and NutriScape.NET. As a dietitian since 1992, Steph has had experiences in consulting, 15 years in clinical, and has operated a private practice nutrition counseling office for since 2011. Log in to comment and save this article on your board or send your comments to reviews@supplement-sciences.com

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